Member Info for Sparkle1

just under a million today in last 2 hours

dont think anything is leaking... alternate hypothesis: 2 weeks ago, retail investors had majority of shares - i seem to recall about 53% of the company. Thus only 3% needed to be sold to get the ii's in control and then its a bit of a different ball game. Would not be surprised if that was reached in last 2 days/ today. Once the ii's have majority of shares in issue, they can be a bit more active investors maybe.

more share in Synairgen have changed hands today than Glaxo...who have 5bn shares in issue...

half a million changed hands so far today compared to 1.5m in the whole of yesterday.

can no longer buy (again)

I pose a question: if it was Stephen Holgate at Synairgen explaining how a vaccine might work would you trust him?
I think I would. But there seem to be some on this board, for equally valid reasons as mine, that say no, i'd only trust him to dose me with a very strong anti viral drug and not a vaccine. That makes no sense to me. You either trust the guys and many on here attest to his ethics or you dont. If you kind of see my lateral logic.

think how scary anything is depends on who you know is dying tbh.
I think medicines has come on a lot in last 40 years.
I also have zero faith in both our current government (and zero in Hunt, Han****, Boris or Dido Harding) and the administrators running the hospital trusts. I do have tons of faith in the docs at the top of their profession whose professionalism and care would prevent them from using something disastrous. Thats one reason why a lot of primary research now comes out of the Unis not the drug companies.

Son can have vaccines... indeed is top priority to get flu vaccine - anyone who gets mild covid and then flu on top will die of flu this winter... gov trying to buy enough flu vaccines for all... but so far has enough for everyone over 50. Everyone on shielding list will be vaccinated first, i believe in first 2 weeks of Sep. There are going to be special centres set up - i was told by doc that Ascot racecourse for example has been requisitioned for vaccinations.. Not sure the at risk people can have live vaccines - think they have to not be live. Think people on tamoxifen and methotrexate might be added shortly too - a lot of these things you cant give interferon beta to them so not sure it will help those shielding with critical underlying conditions. It will help those who appear to not have the right sort of ACE receptors - there is now a gene test to see if you are eg 30 and actually vulnerable.... have invested in that too....

Its not just transplant patients... its most cancer patients too...
From what i gather from the london teaching hospital and the oxford guys, it normally takes:
2 to 5 years in discovery phase on what to look at - apparently this has been essentially done over the last 10 years as they have been doing work on sars1 and coronaviruses for years. the flu vaccine is changed every year to cope with mutations so
my understanding is that this 2-5 years has already been crushed from prior research on the viruses.
I gather therefore that from stage 2, trials take about 2 years to assess and understand immune response. From stage 3, then it takes 5 years to understand how long the immunity lasts in the mass population. My understanding is we are at stage2/3 but that is not such a safety issue as this has been done over the last 10 years, as to an understanding issue as to whether they actually provide immunity over what time period.
Moderna is on stage 3 already 10 years in from Sars1, and has recruited 8374 volunteers and is hoping for 30,000 imminently.
Sanofi makes the flu vaccine so is also already a long way in with GSK. These guys are not starting from scratch.
But generally speaking i agree vaccine uptake is only significant when people you know start dying. On the spanish flu, then the elderly died to start with; the young died the following winter. If that happens with this, we will all be thankful for both a vaccine and interferon beta.

and its astra supplying aussie... sorry, not gsk.

https://edition.cnn.com/2020/08/19/australia/australia-astrazeneca-covid-19-vaccine-intl-hnk-scli-scn/index.html

disagree... have a son with a transplant. The letter from hospital says he cant even risk going in the garden. Has been working from home for 6 months. No-one has yet to survive with a transplant. Neither can they have interferon as the point is that transplant patients are takings immunosuppresants so dont wish to take something that will enhance their immune system... Thus vaccine has a unique place and he isnt going to stay inside for years....
I am now invested in vaccine, testing and Synairgen... place for all to work together.

did everyone clock that GSK has struck deal with Australia to supply the vaccine for the whole population and that the Aussie PM wants it to be mandatory....
Chinese vaccine is going to be tested in Dubai as they dont have enough cases in China.
slightly disagree with comments on Remdesivir below as now being given to thousands of people so they are building database very quickly.

Inhaler...are you referring to what NY Times published on 20 July?

https://www.theguardian.com/sport/2020/apr/21/experts-inquiry-cheltenham-festival-coronavirus-deaths

All sanctioned and approved by Dido Harding, in the full knowledge that people would die from the virus as she took the decision on the board of the Cheltenham Race Course. Now appointed to head up public health england replacement. What a joke.

Just seen she has been appointed to head up new pHE Body... disgusted....
On board of Cheltenham race course who voted to go ahead knowing that it was a public health risk and the virus was on the move.
Ran Talk Talk and had one of the largest breaches of data confidentiality ever in UK. Refused to take responsibility.
Was middle management at Sainsburys before that.
Happened to go to Oxford with Boris.
What a joke. Will be about as good as the [world beating] testing system.
Lets appoint someone who cant keep data secure and who has no knowledge of public health. Tick box.
Makes me want to live somewhere else.

it would probably kill her as she has lupus so is compromised
that is one issue - people who are on serious list, transplant patients, cancer etc are taking drugs already which are designed to lower interferon so bit of an issue to suddenly boost it. This isnt for everyone. But it is for many.

cant buy any at all now???

cant buy any at all now

re Han****: The news this morning on GSK/Sanofi is good as it is indicating that there is long lasting effect. The brit were the first to use steroids to treat so he could be referring to that or to Synairgen. Both are on his radar and numerous of us have written to people from Cabinet members to MPs to members in the House of Lords so we know its on his desk.

I think in my saner moments, that they will have to do further trial on people with co-morbidities such as diabetes and cancer as you need to know whether you might save them from covid but kill them from the underlying desease. I think this will have to be done before they dose up all the people over 60 and i hope they do as it would kill the company if there is an interaction with a major drug and people start dying of their original desease. I hope they are patient. I've been in 5 years; can wait.