RE: AVA 004 Immunotherapy24 Jun 2021 12:59
PD-L1/PD-1 axis suppresses the immune response in tumours e. g. makes T-cells inactive. This is the checkpoint so anti PD-L1 like Tecentriq is a checkpoint inhibitor that targets this so that the anti tumour T-cells are not inactivated.
Avacta say research in mice shows good safety profile and better pharmo kinetics than Tecentriq