Member Info for sadoldgit

Good evening PC1954.

Had a little delve.

Now a may be barking up the wrong tree here.

Roger Meier was director of Acthera Therapeutics that started up in 2019 and went into liquidation in early 2024.

The company developed liposomes for the purpose of transporting small molecules to the required site, thus enabling far lower doses to receive the desired effect.

https://www.swissbiotech.org/listing/acthera-tx-closes-seed-a-financing-and-strengthens-team-to-advance-its-novel-hard-shelled-liposomes-targeted-release-technology-platform/

It may or indeed may not be that this individually may be involved somehow with 737 and its development.

If we look at the liquidation of Acthera in early 2024 it would be a ripe time to set up another company. Buy the technology and have developed elsewhere.

Such is his knowledge and that includes investor finance.

It may well be and certainly cannot be ruled out that he could possibly be a candidate of new CEO

He would come aboard as a largish shareholder too.

There is nothing price sensitive if this were to be the case.

To me he sits perfectly to fit the bill

Now l am not for one minute saying this is the case.

Why invest in Sareum 1.2 million and not in a company that is developing 737?

Or maybe he has.

I may be barking up the wrong tree but a long while ago l did post an article that speculated on the use of liposomes to concentrate chk1 inhibitors to areas of target.

Regards

BoD l gather will know of very little about 737 development.

1801 they most likely in informal discussions.

Now is an opportune time to award share options

in light of future development.

Sp at low price, news if only the received 12 month payment with share options although not much should give a tad of an up tick.

Informal discussions may well lead to formal discussions in the not too distant future with the so called interested parties.

I would hazard a guess that anything to with on licence the most significant aspect is upfront payment.

Low upfront payment indicative if a risk that a company will put forward.

Longer term toxicology trials with positive data will benefit 1801 here. I have every faith in the compound.

Sareum sits as a minnow in a world of sharks.

The problem for a potential licensee is should toxicology data prove to be as good as we expect then they risk being out gunned by a better offer from another pharma.

I am hypothesised here but a pharma in informal discussions saying this is what our offer is until.you can confirm safety with additional long term studies.

We may well be in discussions with a company that has the capabilities and expertise in carrying out clinical trials being an interim from Sareum to a far bigger pharma.

Just my thought on this and don't take it as gospel.

The only question l have for the BoD at the moment is how far is SDC1801 from pre clinical trial completion and when do they intend to complete by?

Sareum are very good at giving a hint of information with no follow up and regular feed back of exactly was is happening.

Options l see as a positive indication of stronger SP to come albeit not imminent.

Regards

Https://charlesgillow.substack.com/p/letter-to-stephen-lightfoot-on-his?utm_campaign=post&utm_medium=web

Slight correction. Change of word from donation to funding. That the term used by the UK government.

Https://www.politico.com/news/2022/09/14/global-covid-pandemic-response-bill-gates-partners-00053969

In addition Bill Gates foundation has donated over 3 million to the MHRA.

In general clinical trial study is not regarded as commercially sensitive

There are however elements that maybe regarded such as theanufacture of.

'Clinical trial data is not always considered commercially sensitive, but it can be in some cases:

Generally

Clinical trial data is not considered commercially confidential and can be released. This includes information on the development of a medicinal product, environmental risk assessments, and risk management plans.

Exceptions

In some cases, redaction may be necessary, especially if innovative study designs or analytical methods were used.

Commercially sensitive information

Some information in clinical trial data may be commercially sensitive, such as details about the manufacturing of clinical trial materials.'

Fortunately we have very hefty patent protection in place regarding the manufacturing of our compounds.

I will add that it is important to achieve very high purity. Ours l believe are pretty near if not 100%..

Regards

On addition we have no observed increase in creatinine levels.

All to look forward to in the clinical trial report.

Imperative is the safety of.

Dose limiting toxicities is the name of the game.

With a few exceptions it is the dose limiting toxicities which limit the efficacy.

Deucravacitinib is one of the exceptions.

I would suggest that we are, should the data confirm what we know so far, be best in class with regards Tyk 2 Jak1 inhibitor.

There are other inhibitors being developed mainly monoclonal antibodies which tend to out perform jakis. The cost of treatment however is very expensive in the region of 100k per year.

It was big news at the time and always on the news which back then was only news and can be trusted.

I remember as a 9 year old watching from start to finish.

But certainly agree that we form our own conclusions based on the information we are fed.

But we should examine the source of information if we can from point of origin as in what actually hapoened.

1969 most people only had a black and white TV and there were only 3 channels.

The BBC were top class then only reporting of facts.

Why on Earth would Russia dispute that the US put a man on the moon? The Russians put a man into space first.

As for an arch enemy, the Russians applied for NATO membership, sometime way after that, but was never accepted.

Is it a conspiracy theory that the US are in pursuit of control of the world.

We can take a look at Agenda 30.

Ot is down to the individual as to what they believe to be correct.

I have seen fo many lies take place by companies.

False reports made on events that have happened.

I get told about an event on a Nuclear power plant around 20 years ago.

The new brigade tell me what the cause of the problem was. I say no it was not.

I get laughed at.

One big difference in that l were there at the time when it happened and were witness to.

Now a person comes along and asks me what happened and then ask those that have read the documented reports to what happened.

Who will this person believe?

I can state as a fact yet what is in a report is fiction.

Always a pleasure to see your posts HbD

Regards

Https://www.nimbustx.com/2022/12/13/takeda-to-acquire-nimbus-therapeutics-highly-selective-allosteric-tyk2-inhibitor-to-address-multiple-immune-mediated-diseases/

Good evening HbD

There are differing conclusions with the link you have pit to the link l have put

Which one is correct or neither?

One is from the national institute of health which is a government body, the other is from Science Direct a non government controlled body.

The US government extremely unlikely to allow any information pertaining to the short comings of covid vaccinations to be released.

The claims made against the pharmaceutical potentially would be horrendous.

That would not be good for the very large global institutions that own these pharmas and influence /control governments. The US in particular.

Democrats and Republicans are at loggerheads over origin of covid19.

Is it from animals

Or is it from the Lab?

Chinese have now said it is from animals, dogs l believe as was found to be internally with covid 19

The question here is why has it taken over 3 years for them to release this information if it were known at the time.

Both the US and the Chinese government, l believe covering up.

Gain of function was being carried out in the Wuhan Lab. Work here was being carried out on reverse engineering which is banned in the US however, Fauci had been paying for these services to be carried out.

First thing he said was that it could not come from a lab?

How the GDMF know that?

The result on origin remains inconclusive.

Regards

Potnak. I am correct though!

The cytosolic accumulation of the nms-mRNA and the reverse transcribed cDNA molecules activates RNA and DNA sensory pathways. Their concurrent activation initiates a synchronized innate response against non-self nucleic acids, prompting type-I interferon and pro-inflammatory cytokine production which, if unregulated, leads to autoinflammatory and autoimmune conditions, while activated TEs increase the risk of insertional mutagenesis of the reverse transcribed molecules, which can disrupt coding regions, enhance the risk of mutations in tumour suppressor genes, and lead to sustained DNA damage.

Susceptible individuals would then expectedly have an increased risk of DNA damage, chronic autoinflammation, autoimmunity and cancer. In light of the current mass administration of nms-mRNA vaccines, it is essential and urgent to fully understand the intracellular cascades initiated by cellular uptake of synthetic mRNA and the consequences of these molecular events.

From 2023 well worth a read.

https://www.sciencedirect.com/science/article/pii/S0306987723000117

Potnak, there is no need to insult people.

Just who in the hell do you think you are to state that someone is playing MMORPG and don't even know it?

You then suggest that the individual should read the idiot Brain and the irrational Ape, This is a further insult and attempt to undermine.

This coming from somebody that, as the MHRA were unable to approve CTA then repeatedly stated that there was something wrong with it.

Where did you get the information that there was something wrong with 1801?

You are very unbalanced sir, talking of multi billion pound valuations one minute and the next predicting doom and gloom by inferring serious faults with 1801 or the return of 737.

Regards

Good morning PC1954.

Trust you are recovering well.

Look forward to the bb getting to a tad of normality.

I can see reasonings on both side but ends up in a bit if a bun fight.

I do find it odd that their are individuals that place no importance on the actual compounds we have or have a financial 27.5% interest in, is that this is the very foundation leading to the success of the company.

If the compounds do not perform as we or the BoD anticipate then alll is lost.

We are performing damn well with 1801.

1801 has out performed Beprocitinib regarded as one of our biggest competitors by having no observed increase in creatinine levels

Both Tyk2 and Jak1.

Clearly one fir whatever reason is out performing the other. Attention to detail in not looking at the pluses of a compound but also the weaknesses and tweaking the compound to overcome this.

Many here neither understand or realise the importance if this.

Tim mentioned a while back that the world will soon see what we have.

Now we see areas in the phase1 trial that posotively exceeded that which sareum had expected.

People do not devote most if the lives in creating something to be 2nd best.

Take care and look after yourself

Regards

Ps l must shorten my posts!

Good evening PC1954,

Sepsis is as you know is a life threatening condition and imperative that it is caught at an early stage.

Good that you have a nagging wife in this instance.

I wish you a speedy recovery as having sepsis myself around 5 years ago.

Started with a little black dot on left calf.

Went to doctors they gave me some antiseptic cream.

2 days later little dot turns onto a little hole will not heal and emitting of fluid.

Went up the quacks following afternoon, cleaned it put some antiseptic on and a bloody great patch dressing.

Went back to work, whilst walking l could feel liquid running down bottom of calf.

I sat on a chair lifted trouser leg up and the patch had burst.

Now they had given several patches to replace when needed.

After 2 days not looking good. I now had 2 holes side by side which were now black.

The following day after work, l see my calf with two black holes side by side looking like a figure 8.

I take myself up A&E. Go to reception and nurse asked what is problem.

I say l have an infection on my calf. She asks to see it. I show her, so she then says take a seat and wait.

Within in 10 minutes l get called.

In l go, a few questions asked, quick examination.

The nurse the sticks what looks like a crochet needle into the black holes and pulls out what must be dead black flesh.

The area around was red and my calf had started to redden and become inflamed.

A quick rinse with some iodine which made my eyes water a tad, a dressing and fluxucillon 2 mg per day for 7 days.

Make sure you take for full 7 days l am told and limit alcohol to 2 units max per day.

Within a day inflammation gone,

A couple of days later signs of healing

The 2 holes you could put a polo mint in each and not be above the surface.

Antibiotic worked fine.

Point l make and l do ramble on a bit is it is imperative to get treated for anything that resembles sepsis ASAP.

As a side note one of the older lads l worked with Went into hospital for treatment and developed sepsis and whilst he has recovered Went through a very bad period.

Far more serious than mine as was supposedly caused by a catheter. He had no signs as such just pain and fever. He did delay and it was his wife that basically dragged him onto the hospital.

Early stages are treatable fairly easily, once it develops further and it will very rapidly the prognosis is not good to say the least.

Several millions of people die each year from sepsis, a fairly simple task if caught in the very early stages.

Regards and take a good rest on your road to full recovery.

Ruxolitinib a Jak1 Jak 2 inhibitor has shown promising results in sepsis albeit still at preclinical stage.

Surprised at some of the information contained on sareum website.

Extract below 2021

Conclusions: The combination of SRA737 and adavosertib caused cell death in TP53 mutated cell lines. There were differences in the DNA damage repair mechanisms in across cell lines and the combination showed significant activity in the xenograft models studied. The combination of SRA737 and adavosertib warrants further evaluation for the treatment of selected TP53 mutated cancers.

Goid morning Colbaltblue.

I don't often agree with you but 100% agree on this one.

So l see as worst case scenario for 737 as being handed back after payment is made.

If in this scenario it is handed back then to me indicates a deliberate delay tactic being used to delay 737 into commercialisation.

There are competitors out there who have spent billions on pipelines that a CHK1 inhibitor such as 737 in combination therapy would severely threaten the financial annual turnover of current approved treatments used in certain cancers.

Looking at the positive side it will take a considerable time to carry out investigational studies with compatible in combo therapies to prepare for clinical phase trials.

The current holder will experience a similar degree of toxicology safety related investigations and to a standard expected by authorising bodies that Sareum are experiencing with 1801.

I am of the opinion that the latter is the reason for no development updates.

Regards to all.