Member Info for RichTheNewbie

Thanks Candid.
Yet another indication, amongst countless others, of growing confidence in the usefulness of IFN-B, and SNG has the great advantage over all the others, that the IFN-B is not only delivered direct to the target area (potentially enabling higher dosage and efficacy), but perhaps more importantly, it's in an easy to deliver form, that can be packaged, shipped, doesn't require doctors/nurses to administer, and in a form that would be preferable to almost everyone, via inhaler/nebuliser (is there anyone who on the planet who would choose an injection over an inhaler!?)

Every prediction ever has been wrong here? Hah. You can't have read anything I've ever posted here then :p

Having taken an extremely large position in both spreads and shares at 6p (as I posted here at the time), I did more than fine with my predictions thanks, and was well served by ignoring the doom mongers. Having sold out a few months back, I've bought back a moderate position, and will again being ignoring the doom mongers, who seem to think the price pulling back means everything rather than nothing.

Forest24 - Indeed and luck will be a factor.

If they were very unlucky, too many of the patients in hospital, or at home, will have started the treatment late in the virus progression, and lessen the impact.

I'd rate results chances as COPD showing meaningful improvement: Good to high
Hospitalisation chances of showing meaningful improvement: Moderate
Home-treatment chances of showing meaningful improvement: Good to high.

That's not based on blind hope but based on all the other studies done using IFN-B (and SNG's studies will have better exclusion criteria than many old ones).

And with the further caveat that I expect that impact to be more significant in earlier stage patients (rather than late-stage COVID).

I'd be quite surprised if either results were dud, bearing in mind existing evidence, from SNG, and unrelated interferon beta studies. However, ignoring that, bearing in mind the particularly aggressive nature of COVID, and the cytokine storm being a significant factor in patients worsening, I could imagine that even if COPD didn't show particularly strong results, the problem that exists with COVID, could be more directly impacted, by the immuno-modulating/regulating effects of IFN-B.

Obviously this being with the caveat of this being a total layman's opinion (I do happen to have read an awful lot of studies related to this now though).

Don't say that _Mr_Big! Your joke was equally offensive to BLM as mine! It'll get reported next and removed!

Yes, let's drop it, I do have sympathy for the BLM cause.
You're clearly one of the many people who cause problems with their desire to be offended on everyone's behalf. Although you're right, I don't have empathy with people offended a joke which mocks Primark shoppers whose priorities are getting a T-Shirt rather than preventing more deaths from the virus.

You clearly need to go watch some comedians who do stand-up about people who get upset/angry/abusive because they don't understand that the subject, or words, that a joke mentions, isn't the same thing as the target of a joke. Ricky Gervais has a particularly good section about this in one of his stand-up shows (think it's probably Humanity).

Had something weird myself recently Bella (and did the test which was negative).
Like a mild/moderate flu, with weakness, mild fever, strange dry throat, and appetite took a week to come back. By the time I got tested through, I was starting to feel better, so perhaps too late to detect it (if it was the virus). Will never know!

Lot of odd numbered sells (therefore I think it's probably mostly just PI's).
I imagine a certain chunk of people will have just gone all-cash after all the negative news about world situation over the weekend (despite the fact this may actually be good for this).
Personally I trimmed my own positions on other stocks (as I think there seems to be increasing chances of a further big dip on the markets before a proper recovery). Also leaves me more money ready to bung in here at short notice if I choose to.

MassiveRay - yeah, would be a sad state of affairs if I joined the rafts of joyless people in this world, who take themselves too seriously, and are offended by everything.

Bella - Sadly I seriously doubt 99% of the people in those queues have had it. I think people just don't believe they'll get it general and stupidly aren't worried about it if they do (let alone spread it to others).

Lol. News showing massive queues of *******s outside shops like Primark today apparently. Sod the virus a cheap tatty T-Shirt is more important! ;)

Yeah, and that's probably based on the rising US covid cases, and a bit in China coming back.
Good chance the UK will follow suit with some more cases soon after all the protests, busy beaches, large raves, and people generally starting to ignore the distancing rules.

enough of it = enough interferon beta

The more I studies read the more I become convinced that it'll be surprising if SNG001 doesn't work.

Essentially I think the caveats will be:
- It's not going to be a magic cure for the virus at all stages (COVID or otherwise) and isn't supposed to be
- It's probably not going to help as much once the damage is done (later stage COVID)
- It's probably not going to make much difference to healthy individuals who produce, and continue to produce, enough of it

Where I'd be very surprised if it doesn't work is:
- In early/mid-stage COVID (or other virus)
- In individuals with various underlying problems
- Other individuals who might be healthy but the immune response doesn't cope well enough and ends up causing more problems (Cytokine Storm)

Existing combination studies have already shown (triple method ones for example) that the interferon patients fared better. To quote The Lancet: "This significant difference was sustained in a subgroup analysis of patients who were enrolled within less than 7 days of symptom onset (52 patients in the combination group, who received interferon beta-1b, vs 24 in the control group) but not in the subgroup of patients enrolled later than 7 days from symptom onset (34 patients in the combination group, who only received lopinavir–ritonavir and ribavirin, vs 17 in the control group)."

Therefore, Synairgen, armed with the knowledge (that didn't exist in older studies) that corticosteroids are a likely interaction (often used to treat respiratory problems) and ability to confirm actual virus presence rather than just symptoms (another flaw in older studies). They should have a much better chance of showing impact than ever before.

It would be a lot weirder, if delivery of interferon beta, direct to the area of the body that needs it, didn't help those people who don't have enough of it, to help the body fight off viruses safely, rather than spiralling out of control!

Combined with previous statements of "This novel approach is designed to reduce infection risks for both patients and front-line workers". So being lined up as a prophylactic for front-line workers....and there's fkin loads of them here and worldwide.

Miggy007 - I liked the line: "The researchers hope a strong result will allow the treatment to be rolled out immediately."

That's the stuff dreams are made of SP wise. Straight into production with a wholly owned drug.

Heh. The Tory party of the past 5 years or so has almost turned me into a leftie ;)
I would have even contemplated voting for Corbyn in the last election, and I think he's a useless cretin who would slowly drag the country to ruin, but thankfully didn't have to make that choice as Labour had zero chance in my area and Lib Dems were the easy choice. Dragging the country slowly to ruin is still better than Boris' rush to Get It Done as quickly as possible though.
Now there's a post that should irritate a lot of people :) (on which note I think I'll retire for the evening so I don't have to read any irate posts in response from any of Bojo's many lovechildren!)

“ I'm quite surprised now that Synairgen and others and the Governments were not more advanced with preperations and treatments”

If you’ve not seen it, watch the Netflix pandemic documentary, can’t remember the exact title but I’m sure it’ll probably be first or second match if you search on there for pandemic.

They basically predicted, down to the very last detail, everything that happened. And was released a month or two before it broke worldwide.

Of course this isn’t because the documentary makers are Nostradamus reborn. It’s because governments around the world have never been more useless and ignored all the repeated warnings. Just like, as the pandemic was known about and starting to spread outside China, countries with decent leaders watched what was going on and acted to stop it taking a major foothold in their country. Whereas the racist/xenophobic/nationalistic/idiotic leaders like Trump and Boris dithered, acted far too late, and gave out helpful suggestions like injecting yourself with disinfectant or being “aware” of the virus.