Member Info for RichTheNewbie

Oh, it's starred out the c0ck from his surname, you'll have to fix that to click it :/

Not SNG related but anyway: https://twitter.com/ParodyHan****/status/1272835856177532928?s=20

You can real boil things down to: if it's shown to have worked well in COPD, there's a big market for this, and it'll be worth lots.
If it further shows efficacy against COVID, there's an even bigger immediate market, as the virus is unlikely to have gone away by then (and some regions are still rapidly increasing in cases).
On top of that, if it shows efficacy in COPD and then also COVID too, then there's a pretty strong chance that the whole SNG premise, that inhaled IFN-B helps people recover from respiratory problems, works, and therefore would have a good chance of helping against a wide variety of viral-related exacerbations, not just COVID.
What's the value of that? The million dollar question. Or should I say billion dollar question.

And the timing of COPD before COVID could be a material turning point.

If the data shows it works, you'd essentially have a free ride on COVID, knowing you'd got the company-making results already in the bank.

Borsaci06 - I don't think you can definitively assume/infer that. However personally I do think they've stopped selling for now. Furthermore based on the trading. I think you've actually still got a background buyer on this. And are regularly seeing round-number trades cropping up in batches on the buy side. Some more now and the ask has just gone up to 36p.

We shall see.

What do you do if you want people to sell in order to fill some buy orders.....
Make it rise but stall and get people to take profit.
Make it drop a bit below what people think the floor is.
Bingo.......you've freed up lots of shares from the PI's who purely react to the price movements.

"Synairgen plc (LON:#SNG) has received approval to test its lead candidate to treat patients with coronavirus"

Well duh. It's had approval to do that for months....that happened back in March (in the first RNS relating to COVID).

I don't really understand what you're trying to say Nolupus. The point is they use IFN-B and ideally avoid the cytokine storm completely or are able to reduce/limit it.

I'm not on furlough and no there doesn't appear to have been any large seller for a few days.
Any other silly questions? ;)

Looks like the scaremonger crew are very late today. Must have been back on the tills at Primark all day.

Nolupus....yeah - but that's a pretty crap list!
If I get a choice in 3 months time of inhaling IFN-B, or taking that drug, based on current information, I'd take the IFN-B all day long! ;)

Ghia - yeah I too would have thought we'll see one today or tomorrow (and not because of any silly code!).

OK I'll give up on posting the side effects and risks of that drug as it'll be about 5 or 10 more massive posts!
(They're summarised on here: https://investor.lilly.com/news-releases/news-release-details/lilly-begins-phase-3-clinical-trial-baricitinib-hospitalized )

Barcitinib/Olumiant:
IMPORTANT SAFETY INFORMATION FOR OLUMIANT (baricitinib) TABLETS

WARNING: SERIOUS INFECTIONS, MALIGNANCY, AND THROMBOSIS

SERIOUS INFECTIONS: Patients treated with Olumiant are at risk for developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. If a serious infection develops, interrupt Olumiant until the infection is controlled. Reported infections include:

Active tuberculosis (TB), which may present with pulmonary or extrapulmonary disease. Test patients for latent TB before initiating Olumiant and during therapy. Treatment for latent infection should be considered prior to Olumiant use.
Invasive fungal infections, including candidiasis and pneumocystosis. Patients with invasive fungal infections may present with disseminated, rather than localized, disease.
Bacterial, viral, and other infections due to opportunistic pathogens.
Carefully consider the risks and benefits of Olumiant prior to initiating therapy in patients with chronic or recurrent infection.

Closely monitor patients for the development of signs and symptoms of infection during and after treatment with Olumiant including the possible development of TB in patients who tested negative for latent TB infection prior to initiating therapy.

MALIGNANCIES: Lymphoma and other malignancies have been observed in patients treated with Olumiant.

THROMBOSIS: Thrombosis, including deep venous thrombosis (DVT) and pulmonary embolism (PE), has been observed at an increased incidence in patients treated with Olumiant compared to placebo. In addition, there were cases of arterial thrombosis. Many of these adverse events were serious and some resulted in death. Patients with symptoms of thrombosis should be promptly evaluated.

WARNINGS AND PRECAUTIONS

SERIOUS INFECTIONS: The most common serious infections reported with Olumiant included pneumonia, herpes zoster and urinary tract infection. Among opportunistic infections, tuberculosis, multidermatomal herpes zoster, esophageal candidiasis, pneumocystosis, acute histoplasmosis, cryptococcosis, cytomegalovirus and BK virus were reported with Olumiant. Some patients have presented with disseminated rather than local disease and were often taking concomitant immunosuppressants such as methotrexate or corticosteroids. Avoid Olumiant in patients with an active, serious infection, including localized infections. Consider the risks and benefits of treatment prior to initiating Olumiant in patients:

with chronic or recurrent infection
who have been exposed to TB
with a history of a serious or an opportunistic infection
who have resided or traveled in areas of endemic tuberculosis or endemic mycoses; or
with underlying conditions that may predispose them to infection.

I think Eli Lilly have a good PR team based on their press lately ;)

Side effects and risks look pretty awful from their drug.

SNG already ahead with interferon beta, known to be much safer, and will hopefully prove, even earlier than them, the beneficial effects, avoiding the cytokine storm.

I would suggest you block the people posting these messages. There are a load of idiots on Twitter - often with multiple accounts/identities (and a few good ones hiding amongst those masses).

From SNG old documents:
"Since then, we have selected and exclusively in-licensed a
novel formulation of IFN-beta for the treatment of respiratory
diseases by inhalation from the Rentschler Group of Germany,
including appropriate access to the regulatory and safety data
that supported the marketing authorisation application for
systemic administration of IFN-beta for multiple sclerosis
sufferers. This patent-protected formulation has many
advantages over alternative IFN-beta preparations and is
suitable for both clinical development and the marketplace."

The documents are old but I can't find any reference to changes and SNG seem to have all their bases covered with patents or in-licencing.

CW25 - Rentschler

Can't see anything on Twitter. Probably some untrustworthy cretin I have blocked. Let me guess someone like smallcappick or one of the many connected accounts?

CW25 - no. I can't remember the name of the company but it isn't them. Think it a germany company or one with a german sounding name without checking.