Member Info for RayPointer

Yeah, It does seem that scientists are waking up to the fact that antibodies may not be enough to defeat Covid19 in the old and vunerable.
Memory TCells last for years rather than weeks or months.

Vulpes may have preferred to have invested the money as shares but the possibility of Vulpes gaining 30% of Scancell was real at the time so they agreed to have CLNs instead. That possibility has receded now.

IMO it's a vote of confidence.
Vulpes want more shares at this level.

Hi Ruck

"Renal" is the 4th according to a recent presentation (Feb 2020)

https://www.scancell.co.uk/Data/Sites/1/media/docspres/presentation-to-lsx-world-congress-february-2020.pdf

Slide 14.
I guess they may have targets on the bench waiting to come on as well.

Thanks for that Wild.
I suggest the trial should have frequent spelling tests. :-)

The phase 1 whiskey trial will, of course, be looking at safety.
It will only progress to phase 2 if shown to be dangerous.

LOL
I also dream of coming in to bat in the final innings of the final match in an Ashes series. The series is tied and England are in a desperate match situation but a brilliantly crafted unbeaten century by yours truly sees England home.

To me the most important of the 3 possible trials is the modi1 trial. I certainly don't think Lindy will tempt fate and try to use a new delivery method on this. It sounds very much that it does not require a special delivery. It is powerful enough in its own right and unlike IB it does not require dual presentation to become effective. So, maybe chester's calendar is a bit pessimistic for modi1 and this trial will get going as planned in H1 2021. This is not really a single trial, it is 4 cancers in 1 trial. Imagine the excitement if all 4 are deemed safe in phase 1 and immune responses are detected in all 4. So in this case the best possible scenario is good preliminary data in all 4 by end 2021. No prediction on the SP if this happens :-)
Imagine also if the above result coincides with good data from the SCIB1 trial.
Wake up Ray and stop dreaming some would say. :-)

However, I do think that maybe the Covidity trial will be held up until the delivery method is perfected. Hopefully we will hear more of this in the presentation.

They may have consulted Ugur Sahin or Keith Flaherty and I have checked that these 2 gentlemen do not live in Luton.

Yes, it would be fascinating to know what Redmile's endgame is at present, and also Vulpes for that matter.
Are they intending to stay in the game until Scancell reaches its full potential or will they start taking profits at some point?
Of course the endgame may change as events unfold.

WTP
I think you will find that the common link is citrullulination.
My understanding is that this is now known as one of the causes of RA. Lindy worked out citrullination may be caused by stressed cells hence her initial Moditope research knowing that cancer cells are also stressed.
Lindy has now researched the sequence of events that ends up with citullination and this sequence is also of great interest to RA researchers such as Karolinaka. Lindy seeks to exploit citrullination and encourage it whereas Karolinska presumably are looking for clues as to how to stop it happening.

It's hardly the most important question to be asking about Scancell at the present time.

The big buyers are late this being Scancell :-)

Yes, its interesting about the 3 slots.
I wonder what Lindy's view is on human challenge trials.
You probably couldn't expect the people most at risk to join these trials and these are the very people that need protecting. They probably aren't allowed to join the trials anyway.
So I would guess it is only fit and healthy volunteers who are likely to recover quickly anyway with or without a vaccine.
I am also guessing what you are looking for is for the vaccine to defeat the virus much faster that an immune system without the benefit of the vaccine.
So, having proved the benefits on healthy individuals what happens after that? Do you go for a phase 3 for the people most at risk perhaps with a little more confidence?

It could mean that Rats would want to pay a good deal more to get the quality.

Companies like Barclays always want to stimulate buying and selling of equities. That's one way they make money.

But its great that the UK government vaccine taskforce now recognises how critical a good T Cell response is.

As for testing Covidity.
That may have to wait for the Phase 1 trial.

That's interesting WTP.
Of course Covidity will be off the scale. The high end that is :-)
But joking aside, I would expect Covidity to show a high reading.

For Covidity, as I said before, the key may be that the delivery method has been finalised