Member Info for ratcliffewriter

A little tick up anyway...

299 quid?! Ridiculous! Lidl are doing one for 149 next week, with a pack of needles and six free mice included.

Interesting to see what information a little research can unveil - scancell does have a policy of continual refinement so a more informed look at patent procedures and tactics is worth taking into account. Research will also tell knowelsi that the word 'opinion' only has one 'p', not two.

C7 - Maybe the MMs wanted to scrap for those sells, but had to SCAP instead...

Not wanting to scrap, but I reckon there may be some decent weather coming up over the Bank Holiday weekend.

TF - what on earth is there to scrap over on that opinion of C7's?!

C7 - See if you can find what refreshments they are providing then. If they run as late as they have been doing we'll end up with a Full English breakfast at 2.30p.m. Or more likely a football themed dessert - or 'sweet f.a.' as we call it.

One of the reasons for having the AGM conspicuously early is no doubt to get approval for a multi-billon pound sell-off of the SCIB platform to Roche, but mainly it is to pre-empt C7's annual challenge when he finds the date of the AGM ahead of the RNS by use of high quality blagwork. Next year you'll have to start hunting in May C7!
Anyway, nice they've got something sorted ahead of schedule....

'Scancell (with Biontech)'. That's like a mouse with a flick knife among a group of cats.

That was exactly the point I was trying to get across, but you've done it much more succinctly than I did! They had different options and when they had decided, the market was told as required.

Probably a shed load of playground stuff unfortunately....!

No dracula. Read it properly. I said 'I reckon I guessed a few things fairly accurately.' 'Reckon' 'guess' 'a few things' and 'fairly accurately' is not a claim of 'getting it right.' It is pleasant surprise at possibly being somewhere in the right direction.

I understand your perspective and agree there was detail not included which they knew and we hadn't sussed, but I think there was either confidence the IND would be granted or a determination to abandon the US arm, but it was unsure which at the time - and the maelstrom of conjecture would have been considerable and ultimately fruitless if those options were laid out then. Also, the trial was never in doubt - the US side did not govern whether it went ahead or not, just whether it went ahead in the US contemporaneously or not. Their loss, not ours. Full steam ahead now.

Just listened to CH - I reckon I guessed a few things fairly accurately in my last post!

Lots of conspiracy theories today, 'cover ups' and deceit to the fore - all understandable, but isn't it reasonable to set your plan out and stick to it - i.e. the US and UK arms of the trial were proposed, and the data would presumably have been gathered and shared simultaneously. The IND was submitted in the US, and preparations in the UK being done, no reason to suppose that the planned timescales wouldn't be close enough to keep them synchronised.. The IND then gets delayed (or obstructed, depending on how you think) but preparations continue in both countries. Eventually it gets to the point where the UK trial is all set and ready to roll (as we were told), patient recruitment under way, and the hope is to get the IND cleared in a few weeks. Then it gets to a point where you go to Ichor and say 'look - we're all ready to roll, is that IND issue going to be resolved in the next few weeks (or couple of months) or not? Because we have a valid trial ready to go and it makes financial and scientific sense to crack on alone if the US arm isn't going to step in pretty quickly.' Ichor then identify or are told of a substantial further hurdle from the FDA, and the decision is taken to separate the trials and progress the UK one because patients are deteriorating or dying due to an administrative delay. The data to be gathered will be internationally valid, the patient numbers are sufficient, and what's to be gained by waiting an indeterminate length of time to accommodate a useful but far from essential US study? Don't forget, Keith Flaherty was perfectly happy with data from the SCIB1 trial that was wholly UK conducted. Also, since the original proposal of the SCIB1/Keytruda study, Scancell's links in Europe have been transformed, arguably making them far less reliant on forging contacts in the US - don't get me wrong, US links are very useful, but they are not essential. Why weren't we given a heads up? Because you don't put out an RNS saying 'the IND looks to be dragging even further, we might quit that side of things entirely but a lot depends on the next few weeks', because you might, you might not, and until you have made the firm decision to abandon the US then what is to tell? I also remember LD at the 2014 AGM talking of witnessing the grotesque side effects of some of the then-current treatments - she was genuinely shocked by them and keen to develop treatments that were more effective and kinder to the patient. I can see her hand being in this decision too - why wait an indeterminate further time for the US when we can make this trial start here, and get valid data to prove what we want to prove? Imo the patients are literally waiting for the go-ahead, and they now have it. Wouldn't surprise me if the first one was injected this morning to be honest, but we'll just have to see what happens next.

'David Evans' bought a million at 7.5p if we are to believe some quarters, and I would think he'd have a reasonable grasp of how things might pan out. So even he is down atm, but one assumes confident of a good return before long.

I understand exactly, but in a less formal environment they might well have asked 'what's the plan if the FDA drag their feet too long.' I would think this plan B has been ready but not required to be RNSd because it depended on circumstances. It matters not now imo because the UK trial is now fully on.

I imagine Diggles knew this was likely - there is an assurance of their long term support, and let's face it if they hadn't got Vulpes in place we'd have an infestation of money-panickers this morning, even though the decision today will save a lot of expenditure and releases them to crack on with the trial right now.

At least it confirms that the impasse is around ichor and nothing to do with the scancell science.

Certainly sounds like an ultimatum was given and any stuck to. The rns says 'Operational activities for clinical centre initiation in the UK have now been completed' and a little further on 'Having considered the ethical issues related to patients awaiting enrolment into the UK sites' it sounds like things will be under way almost immediately, and to my optimistic self it sounds like they are very hopeful of good results.