Member Info for JoeyDiamond

Dr Suzy Dilly, Chief Executive Officer commented: " While considering these results it is important to remember that this is only the first clinical trial using VAL201, so this data has been generated using the utmost caution in sequentially dosing patients. Nevertheless, the headline results clearly demonstrate that VAL201 has the potential to be a safe and well-tolerated drug. With this data in hand, future studies will investigate optimal dosing strategies for VAL201 and help confirm these early indications of a positive response rate."

Yes confirmed by Suzy more trials required timeline likely 6-7 years again

It will have taken 6-7 years to complete the trial of 12 patients

Dose Finding Safety Study of VAL201 in Cancer Patients (VAL201-001)
https://clinicaltrials.gov/ct2/show/NCT02280317?cond=VAL201&draw=2&rank=1

Primary Outcome Measures :
To estimate the MTD/MAD of VAL201. [ Time Frame: The average timeframe is 18-26 weeks per subject ]
Assessment of the MTD/MAD of VAL201.

From RNS
A Maximum Tolerated Dose has not been determined for VAL201, and all doses remain available for further testing.

May be I misunderstand but that means the trial failed its primary outcome? Which would suggest further P1/2 trials are required which will likely take another 6 years.

We expect the 6 month interim results RNS this week, my best guess is Wednesday. Hopefully gives us some guidance.

Ahh further research shows their are multiple cases being argued against the tiktik ban, 2 lower level cases brought by users of the app have already been rejected by court judges.

However the big case sits with US district judge Carl Nichols who will soon release an update

https://www.theguardian.com/technology/2020/sep/27/tiktok-us-judge-set-to-rule-on-ban-preventing-new-downloads-of-app

Fantastic news Tiktok download ban will come into effect from 23:59 ET tonight unless there is a Donald Trump u-turn.

Expect a nice day tomorrow!

https://register.epo.org/application?number=EP11730046

Synairgen have the EU patent for using IFN-B for flu. Wasn't aware of that one

Matt Handjob / Witty / Valance / Bell etc are all well aware on SNG001.

There is little to gain from writing to MP's. Your time and letters would be better off lobbying journalists/twitter celebs asking them to advertise Synairgen and the home trials. Public exposure is the biggest thing now the 2nd wave is coming and many lives on the line IMO.

https://twitter.com/VirusesImmunity/status/1309872571417079808

Prof. Akiko Iwasaki
We found a decline in type I IFN induction in older adults. The culprit here is the degradation of TRAF3 and impaired IRF8 up regulation downstream of RIG-I signaling in older adults.

**
Scientific evidence of IFN-B declining the older you get. Why we see mainly older people getting severe Covid/mortality and hence why children rarely get severe cases of Covid-19. Backs up the observational evidence we are seeing.

Type 1 interferons especially Beta is the most important thing we need to boost/replenish in the immune response to the virus. The science is now overwhelming in Synairgens favour and all the worlds leading experts are concluding we need an IFN-B type therapy.

Its only a matter of time before US or UK government have to cave and give more credence to SNG001. The academic/medical community will demand it.

QD22 I believe there are ongoing trials in hospital.

https://clinicaltrials.gov/ct2/show/record/NCT04385095?term=interferon&cond=covid-19&draw=2&view=record had an additional hospital pivotal arm aded to the trial on 27th August.

Sir John Bell on 22nd Sept in an interview advised Inhaled Interferon Beta was under review in the UK wide Recovery trials.

There hasn't been anything offical from Synairgen but theres enough evidence from strong sources showing more patients are being recruited in hospital.

Just downloaded the logs from https://www.londonstockexchange.com/stock/SNG/synairgen-plc/trade-recap

£250k worth of shares were purchased after close and after that 1 UT trade set price to 165. Outrageous how they can get away with it :)

Apologies that should say Pivotal arm!

We have just had a major breakthrough paper concluding many people have deficient genes relating to type 1 interferons. Published by Rockefeller University and other lead researchers celebrated by experts in their fields like Eric Topol and Prof Akiko Iwasaki. It concludes Interferon Beta not Alpha or Gamma etc is what we should treat people with.

We also have the great news the hospital pilot arm has started in the large UK Recovery trial.

How people are panicing over perceived lack of news or worrying about SNG and its therapy is beyond me.

To confirm

TSI confirms that it has agreed terms for an acquisition of BrandShield Ltd ("BrandShield") in a share for share offer, and is in the advanced stages of finalising an accompanying equity raise.

Anyone heard any more news on this since? Nothing new on their website/twitter etc

The lethality of the virus has stayed the same but is now more contagious according to most studies. That doesn't mean its weaker.

In light of the recent discovery of people with the weakened immune systems and their interferon type 1 related genes. Coming into flu/cold season how on earth can you believe the virus is less deadly.

The unholy trinity of Covid-19/Influenza/Defective IFN type 1 genes is going to be the death sentence for 1000's people.

The politics being played though its too hard to call. There is still the legal injunction in the US court that still may veto it or even a new announcement by Trump. He has a habit of making announcements over the weekend im convinced his buddies take up positions the week before knowing the advance news :)

Conspiracy theory I know but it happens to often!

Bit of a gamble over the weekend again on this share. Price will double if the tiktok ban comes in.

Onwards to £4 then £5 on bumper sales in the interim RNS on 30th Sept. IMO :)

Nice to see on twitter tonight amongst the Professors and senior scientists I follow that they are all retweeting/discussing these new findings. First time ive seen all these well regarded and professional people from mutliple fields getting excited over a paper at the same time.

Forget Synairgen and our shares for a minute, it does feel like here has been a genuine big step forward and breakthrough in the battle vs Covid-19. It deserves to be big news tomorrow and massive thanks to these super cool scientists.

Further information
Immunologist Jean-Laurent Casanova of the Rockefeller University suspects human genetics will end up explaining the majority of such serious cases, however, because the consortium has only looked for mutations in 13 of the 300-odd type 1 interferon-related genes so far – already a huge undertaking. Many other genes, including ones not related to interferon, could affect a person’s response to the virus.

So the 14% figure is likely to be very much higher. It gets to the point that the evidence could point to giving all patients a boost of IFN-B as the first stage drug.

I think you are right. The scientific community now has its evidence.

Now from a big pharma view they have confirmation from independent unbiased sources IFN-B is key to treating many people with Covid-19. 14% of people who suffered with serious Covid in the study had these problematic genes.

Think of how many cases worldwide that is. So many people need an IFN-B drug thats now scientifically proven that is huge revenue.