Member Info for JoeyDiamond

Well the scientists advise this drug can be used in the form of combination regimens (****tails) with drugs that exhibit anti-SARS-CoV-2 activities including RBC, dexamethasone and interferon-ß1b. So potentially you have a much less expensive alternative of Remdesivir to go with Interferon/dexamethasone.

Whats interesting is the theory that already exisiting approved drugs with metal compunds like Bismuth could be effective vs Covid and can be repurposed.

https://www.miragenews.com/scientists-and-microbiologists-jointly-discover-a-novel-antiviral-strategy-for-treatment-of-covid-19-using-existing/

Some new research showing this drug could be 100 times more potent than Remdesivir.

A research team led by Professor Hongzhe SUN, Norman & Cecilia Yip Professor in Bioinorganic Chemistry, Department of Chemistry, Faculty of Science, and Professor Kwok Yung YUEN, Henry Fok Professor in Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine of the University of Hong Kong (HKU), has discovered a novel antiviral strategy for treatment of COVID-19.

They discovered that a class of metallodrugs currently used in the treatment of other infectious diseases is showing efficacy to potently suppress SARS-CoV-2 replication and relieve viral-associated symptoms in an animal model.

You are correct Manifesto Covid-19 is for sure on the rise in the North West and lockdown of some kind is required. People are happy to follow the rules etc. The problem is no one believes this Tory government has Liverpool or other Northern cities well being at heart.

They want to shut down the hospitaility/arts sector and destroy livelihoods without providing adequate financial support to people or provide any coherent plan or provide proper scientific evidence that it will be beneficial.

I think most rational people will see the education sector as the main source of spreading of the virus yet is being kept open.

Im based in Liverpool and feels like rebellion is on its way. All the talk is about a rerun of the 80's under Thatcher destroying communities and businesses.

Feels like a pump and dump play to me. Hope im wrong and its a genuine screenshot.

Whats odd are the comments about P2 pivotal trials then needing a further P3 trial, possible confusion from the broker maybe? I notice none of the longer term members of the board can confirm its validity, only new/unknown posters confirming it so far.

https://science.sciencemag.org/content/early/2020/09/23/science.abd4585

Long read :)

Synairgen don't do leaks, they have a very tight ship as the researchers on this board will tell you :)

https://www.manchestereveningnews.co.uk/news/greater-manchester-news/manchester-students-in-intensive-care-19068537?utm_source=twitter.com&utm_medium=social&utm_campaign=sharebar

Some sad news, locking students away in dorms was never a good idea.

There is no 'offical' relevence to the 15th just alot of cirumstantial evidence from all the detetctive work on this board. I forget all of them now but from memory

A French IFN-B trial Dr in France confirms via ATU SNG001 will be available for use on this date.
Germany regs mean it likely follows suit for compassionate use.
The European Medicines Agency (EMA) meet on this date to discuss approvals etc.

We have signed a MAP with Clinigen so the hope is we get some form of mention/approval from EMA.

There were some other reasons but I forget :0

There was no deramping yesterday a small number of us including me expressed reservations with the RNS and the less than stellar trial results. We even quoted the figures from the RNS and explained the P values etc. Hardly deramping when you are posting real facts.

Hence why some people sold the remaining of their holdings.

Computer909 I disagree. France for example is spiralling out of control and getting worse.

https://www.mercurynews.com/2020/10/07/covid-19-outbreak-hospitalizations-surge-in-france/

As we have seen on this board a number of French Doctors intend to use SNG001 on their patients once available, once successful treatments occur news will catch on fast and demand for SNG001 will exponentially grow.

https://twitter.com/EricTopol/status/1314037117928894470/photo/1

Worth reading Erics post.

Ive read numerous sources that there won't be enough mab drugs to adequately supply even Americas demand, this is after the major ramp ups in production.

Simply there will need to be other theraputics for the rest of the world so the notion SNG001 is beaten to the finish line

On Trump - He is making these riduculous claims as he failed on his vaccine prediction and its harming his election campaign. He is claiming God gave him Covid for a higher purpose. Then told his Dr he knew Regeneron was a wonder drug that cures Covid and now wants to give it free to the people. I think he has lost the plot completely and looks to be his last desperate election ploy.

https://www.almasryalyoum.com/news/details/2056638
SNG001 in the Egyptian news.

https://www.openpr.com/news/2151561/aerosol-delivery-devices-market-value-to-grasp-46-72-million
SNG001 used as an example as to why the Aerosol Delivery Devices Market is going expand and be more lucrative

https://www.linternaute.com/actualite/guide-vie-quotidienne/2484525-vaccin-et-medicaments-contre-le-covid-fin-2020-ou-debut-2021-le-delai-de-plus-en-plus-incertain/
French site advising of the likely drugs coming out late 2020/early 2021

There it is
07-Oct-20 14:17:20 1.55 7,000 Buy* 1.50 1.55 108.50

Thanks pmjh date of that interview September 22.

Listening to it again he definately says inhaled interferon beta is on the Oxford Recovery trials, it hard to believe he is mistaken. The question is why isn't Recovery or Synairgen advertising this?

Bizarre isnt it?

Out of interest what date was Sir Johns interview? I forget

Indeed this is where the confusion comes from with Sir John Bells interview. Possibly he worded it wrong and meant Synairgen had their own trial setup rather than being on the recovery trial.

Hi harlequinrasbora you have a sensible post on the data in the RNS, from the clinical trial I note

Primary outcome measure
The number of patients who demonstrate more or equal to 50% improvement in their cohort specific symptoms as measured by responses to Abdominal Pain Intensity Scale, Stool Frequency and Stool Consistency questionnaires [ Time Frame: Baseline to EOT up to a maximum of 8 weeks, two treatment cycles (one cycle = 28 days) ]

Whats interesting is many of the placebo arm also reported big improvements on their questionnaire which is obviously an issue when it comes to the results. The difference between the placebo and drug is reported as follows

In IBS-C patients (n=76) a numerically superior but statistically non-significant overall response rates of 25% compared to 17.1% for placebo (n=82) (p=0.152), representing an RR of 1.46 (95% confidence interval: 0.791, 2.711); and

· In IBS-D patients (n=94) a numerically superior but statistically non-significant overall response rate of 23.4% compared to 17.8% for placebo (n=101) (p=0.216), representing an RR of 1.31 (95% confidence interval: 0.753, 2.290).

This is why myself and others are not singing from the rooftops. Maybe I misinterpret the results as im not a scientist but as a trader it made me worry.

Blue is correct the RNS is not a good one its average at best. Earlier this morning I told people about the P values too.

Whats also telling in the RNS is

'The Company is currently undertaking further analysis of the study results, including investigation of sub-groups with signals of higher levels of overall response, in order to define the future pivotal clinical development strategy.'

I'm not saying this drug won't make it to market but the major ramping and the amazing RNS posts are far off the mark. Also remember many people have 3 or 4 bagged here so common sense to sell some combined this is why there was a huge selloff first thing.

My mum works in a hospital and they have gone from 0 to 10 patients in the Covid ward in last week. Thankfully none have progressed to ICU yet.

However there is roughly a 2 week delay of rising cases before people progress to hospitilisation/ICU/death so next week expect the numbers to rise sharply.