Member Info for JoeyDiamond

You don't understand P values then :)

P values not as good as hoped - from the RNS

A summary of the results for the FAS (n=353) is given below, showing Blautix® achieved:

· In the IBS-C/D combined group (n=170), a statistically significant overall response rate of 24.1% compared to 17.5% for placebo (n=183) (p=0.0625), representing an RR of 1.38 (95% confidence interval: 0.913, 2.083);

· In IBS-C patients (n=76) a numerically superior but statistically non-significant overall response rates of 25% compared to 17.1% for placebo (n=82) (p=0.152), representing an RR of 1.46 (95% confidence interval: 0.791, 2.711); and

· In IBS-D patients (n=94) a numerically superior but statistically non-significant overall response rate of 23.4% compared to 17.8% for placebo (n=101) (p=0.216), representing an RR of 1.31 (95% confidence interval: 0.753, 2.290).

However considering how little treatments there are out there i'm not sure how the market will take this.

Nice find.

Looks to me their has been a public outcry for SNG001 as Covid cases are increasing. The local authorities have tried to quell the public anger and reduce their expectations with a media campaign.

Nice to know SNG001 is spreading to all corners of the planet.

I was impressed by their company and the team they have, expect some great things from them in the future.

I suspect Venrock were using a small amount of their shares to put persistent selling pressure on the SP. All in order to free up shares and buy more at a lower price. What are the odds we see their holding increase in next TR1 :)

Thanks Wedme for the posts I definately have misunderstood/under estimated the value of IFN-B then. I was under the impression from reading other literature that Interferon should not be used in more severe cases of Covid as the theory was it could contribute to cytokine storms. From NIH health they still advise using against it.

'The COVID-19 Treatment Guidelines Panel recommends against the use of interferons for the treatment of patients with severe or critical COVID-19'

https://www.covid19treatmentguidelines.nih.gov/immune-based-therapy/immunomodulators/interferons/

I also wasn't aware that the anti-inflammatory response was so strong.

If people on this board like me are mistaking the full benefits of Interferon Beta then why are so many in the medical world also not seeing the same potential?

https://www.en24news.com/2020/10/how-apteeus-so-quickly-discovered-a-drug-that-could-defeat-the-virus.html

yep 5 million gone to Apteeus and doesnt relate to Synairgen

Check out the inhaled Interferon trial from France and the chief investigator

https://clinicaltrials.gov/ct2/show/NCT04469491?term=interferon&cond=Covid19&cntry=FR&draw=3

Principal Investigator: Aurélien Mary, MD
Contacts
Contact: Jean-Philippe Lanoix, MD (33)322668813 lanoix.jean-philippe@chu-amiens.fr
Contact: Aurélien Mary, MD (33)22087140 mary.aurelien@chu-amiens.fr

Locations
France
CHU Amiens
Amiens, France, 80480

You can understand why he knowledgeable about SNG001 and why he tweeted the way he has.

We can't trust the national test and trace system as the national database has ran out of rows on 32 bit excel. The incompetence is off the charts.

No wonder Synairgen and the obvious Covid-19 treatment is not helping the public yet.

https://twitter.com/MaxCRoser/status/1313046638915706880

How bizarre it was just a ride along he going back to hospital now.

Just a photo op, how irresponsible and selfish he putting all those secret service at such risk of infection.

Trump released from hospital driving back the White House.

Something not right here, you dont go from Oxygen and Dexamethasone to back on your feet and back to work!

If Trump is on Dexamethasone he is definately requiring oxygen or possibly a ventilator. The steroid is only given to patients with severe/critical Covid.

The steroid is designed to dampen down the immune response to reduce inflamation and to try and avoid the cytokine storm. Essentially its doing the opposite of what IFN-B would do ie boosting your immune system.

If you prescribe in mild/moderate cases you will actually be doing more harm.

Here you go Ghia

https://www.recoverytrial.net/files/recovery-sa2-submitted-to-rec-final-160420-10-14.zip
doc = RECOVERY SA2 Amendment Form 2020-04-07.pdf

Here is the text

Comments/ explanation/ reasons for substantial amendment:
It was not possible to acquire a reliable supply of inhaled interferon beta for the trial and it is not clear that production could be scaled up if results were positive to provide large-scale treatment. The government's Chief Scientific Adviser considered other treatments that would be suitable for testing (on basis of scientific rationale and scalability if results were positiv) and recommended to the trial steering committee to consider azithromycin.

No peer review yet doesnt mean Bojo can't mention us.

He has mentioned Regeneron which isnt peer reviewed or released full trial data so think its a myth.

Cineworld look to be going bust announcing all cinema closures tomorrow.
https://www.bbc.co.uk/news/business-54407213

Pressure for a therapy will be increasing

Regeneron data is the same as Synairgens
The numbers in this early release of information were small and the data has not been peer reviewed yet. Only topline data was available in a news release from the company.

So the Prime Minister is happy to promote a US company drug that isn't peer reviewed or released its full trial data ;/

https://twitter.com/gabrielsherman/status/1312442681662926850

Conversations w Republicans close to WH over last 12 hours indicate it’s been far more dire than WH has said. Before being taken to Walter Reed, Trump kept asking aides, “Am I going out like Stan Chera? Am I?” (Chera was Trump’s NYC friend who died of Covid in April)

Trumps Doctor now saying he made a mistake and didn't mean to say treatment started 72 hours ago which would have made it Wednesday for a positive test.

Hmm the chief Doctor can't remember when he started the Presidents treatment for a life threatening illness :P)

Anonymous source off the record

The President's vitals over last 24 hours were very concerning and the next 48 hours will be critical in terms of his care. We are still not on a clear path to a full recovery." ~anonymous source off the record.

Folks suspect White House Chief of Staff is the source (hes been caught on camera saying off the record)

https://twitter.com/Olivianuzzi/status/1312429131079057409

The implications of the President testing positive and then attending various events from his calendar instead of isolating is huge. 25 people including Senators and White House staffers are now infected and could be a super spreader event. The seriousness of the situation means the Senate has now closed.

This has to be one of the biggest balls up in any campaign ever, all created by a lack of social distance and masks etc, Biden must be astonished at the situation.