The latest Investing Matters Podcast with Jean Roche, Co-Manager of Schroder UK Mid Cap Investment Trust has just been released. Listen here.
Agreed Elon and reddit crew has the potential to make bitcoin crazy highs, the mad conditions are there.
What are the odds today off a wallstreetbets pump on the most shorted stock :)
I have no idea what will happen the market is just nuts at the minute.
https://twitter.com/zerohedge/status/1354789428288512003
spreading worldwide..
Robinhood and other apps have banned buying of GME/AMC/Nokia stocks. Possibly will cause a crash in these stocks.
Lots of money about to be moved elsewhere, could be metals :)
US market opens soon - all eyes on GME / Nokia /silver
https://www.reddit.com/r/wallstreetbets/comments/l68ill/the_biggest_short_squeeze_in_the_world_slv_silver/
Madness in the markets with wall street bets lots of talk about silver being bought up, may have possible impact here?
All 30 AIM shares on my watchlist are red today. These wallstreetbets and PIs vs hedgefunds I think is having an impact on the markets in general.
Lots of money moving and piling into stocks like GME, NOK and silver. Hedgefunds having to cover shorts or double down. This takes money away from other places hence so many stocks in the red.
https://twitter.com/JolyonMaugham/status/1354421647223250946
Thats the reason
I note alot of deramping going on and a good fact based science paper is being lost. Here are the links again.
https://twitter.com/PeterHorby/status/1354322760726683649
Science Paper here = https://t.co/AlV2gI2WAO?amp=1
You mentioned in your post I was ignorant therefore the scientists I directly quoted and the science paper I linked must be ignorant too.
Im glad im unsettling you :)
Indeed Phil its getting ridiculous the level of disruption, deramping and now even calling senior scientists ignorant.
Bizarre.
I haven't screamed about anything as you put it. I have just linked an important science paper and linked various commentry from very senior scientists who are very influential in decision making. I have just shared the research for people to make their own conclusion.
The only person screaming on this board is you as you are desperately trying to disrupt this board.
Thanks Scinv commonly the ****tail contains just 2 monoclonal antibodies. Idea being virus becomes resistant to one the treatment will still work. However what happens if the virus becomes resistant to both!
So re-read the twitter thread in context with the recent paper I shared. See that Eli Lilly mabs ****tail now has both its monoclonals made ineffective against the SA variant.
Now effectively calling Jeremy Farrar ignorant because he says we shouldnt be using single monoclonals is a bit silly :)
Scinv - How many single monoclonals are used in a standard mabs treatment?
https://twitter.com/kakape/status/1354389522759483394
This new preprint by David Ho’s group shows that 501Y.V2 already "is resistant to a major group of potent mAbs ..., including two authorized for emergency use”.
As @JeremyFarrar
told me: “We shouldn't be using single monoclonals."
Thats going a stage further senior people saying we shouldnt be using them. Jeremy is the Director of the Wellcome Trust.
Yes its a major issue from the science paper you can see there is a change of thinking with mAbs. They are not a good solution for longer term use or stockpiling as they likely become redundant if there are mutations.
Fauci, Horby and other key influencers will be concluding the same.
Another important line here 'Several other mAbs in development are similarly impaired'
I need to research more but this could be bad news for AZN mAbs too. These E484K and other mutations could render them ineffective.
https://twitter.com/PeterHorby/status/1354322760726683649
Science Paper here = https://t.co/AlV2gI2WAO?amp=1
Important new data released I suggest everybody read and the implications for mAbs treatments if Brazil or South Africa (or any E484K) mutation becomes prevelent.
Our findings have relevance to the use of mAb to treat or prevent SARS-CoV-2. Both UK?8 and SA?9 are resistant to neutralization by mAbs directed to the NTD supersite (Figs. 2c, 2d, & Extended Data Fig. 3b). More importantly, SA?9 is resistant to a major group of potent mAbs that target the RBM, including two authorized for emergency use (Fig. 2c). LY-CoV555 is inactive against SA?9, and the activity of REGN10933 is impaired (Fig. 2b) while its combination with REGN10987 remains potent (Fig. 2e). Several other mAbs in development are similarly impaired (Figs. 2c, 2e, & Extended Data Fig. 4b) against this variant. Decisions on the use of these mAbs will depend heavily on the local prevalence of B.1.351 or B.1.1.28, thus highlighting the importance of viral genomic surveillance worldwide and proactive development of next-generation antibody therapeutics, including combinations that target antigenically distinct epitopes.
Looks like TILS going it alone to me funding a P3 trial and production ramp up - following similar path of SNG who raised £87 million at a placing.
The 8% efficacy number comes from an unconfirmed german government source according to the reports. Could just be a mischief news story but with how bad the AZN trial was its not one we can dismiss out of hand.
Its what the EMA do on Friday thats important - if they dont approve it for over 65's then its a big blow for AZN. What sensible person in the UK will want an AZN vaccine? You will ask for a phizer vaccine.