Member Info for inanaco

just took another 25,000 .. to ... mad

they are sells ..

shareprice was 19p on the day moditope was announced, it was 6/8p range at SCIB1 phase 1 ....... 32p on the results of Phase 2

and after that great speech .... You also Bought the share today because its cheap .. LOL who are you appealing to ?

Scancells TCR therapy is unique .. no other system can be compared to it, the same applies to the Modi1 vaccine and the moditope platform,, as Scancell is using Cytotoxic CD4 T cells ... nobody else has this technology

don't forget the mage a3 trial of GSK also failed to impress ...

Bermuda ... what has this result got to do with Scancells link with BioNtech apart from the word TCR ? as its a completely different class of antigen and T cell

Ivy you posted the BOD have not done themselves any favours ???

what have the BOD to do with Ichor's new gun ?

Crumbs higher dose = cytokine release syndrome (CRS

"""Seven patients had serious adverse events, including two with cytokine release syndrome (CRS) and one with hemoptysis."""

Adaptimmune said all three trials have advanced to their respective third dose cohorts. The company added that the benefit of its T cell therapies may become evident at higher cell doses where it expects to see higher T cell expansion.'

Just add to Booms post .......... SCIB1 and SCIB2 induce high levels of PD1 expression ... with the attack by the CD4/CD8

PD1 expression is a reaction to inflammation its the way the Cancer defends itself against attack

in Moditope... High expression of PD1 is ignored by the Cd4 t cells they are not turned of by PD1

Cell .............

take a look at this "Antigen structure" with all the bonding sites

https://biology.stackexchange.com/questions/46594/how-is-a-t-lymphocyte-specific-to-an-antigen-but-not-specific-to-an-epitope

T cell binds via its TCR and creates a chemical bond with all sorts going on ... its not an antibody

why are we going down this multiple bonding route ?

like sperm to an egg .... no different

single cell multiple epitope's expressed ....... only ONE t cell would engage

Scancell does not use a Anti-body mediated immune response in Immunobody or Moditope

Now notice what i put at the bottom .......

""""""""" Now the technicals and process of this is IMHO ... so i would welcome thoughts on it """"""""""

thus it required "understanding" did you reply to this comment ... ? Nope

so why on earth would any one on this BB even consider your posts as "Informative"

Can you produce Posts like this .......... if not move on eh !

Inanaco 17 Aug '18

the point of my posts is this ... we know that the three epitopes that are built into the modi1 vaccine are expressed by 17 cancers as per Scancells Moditope presentation to exactly what degree is unknown because scancell has elected to go for 4. So once BioNtech have extracted the TCR's .. thay could potential build up to 17 personal vaccine targets using the same TCR

If BioNtech build a personal vaccine which is very expensive, as per Lindys presentation they can achieve success only in 10 to 20% of patients, which means they have to screen and sequence TEN patients cancer to find one suitable that expresses the neo epitopes which they can build a T cell around to clone out. . Clearly they see this as a commercial Model otherwise they would not do it.That would apply to every different cancer, as you cannot exchange the Neo epitopes from one cancer to another as by the nature they are different so you would have to build a huge repertoire of TCR that respond, a massive task.

But with Moditope TCR they do not need to screen or sequence a patients cancer because they already know that the cancer will have autophagy .... so now the cost tumble because they only need blood samples to build a personal vaccine and indeed the same TCR's could work across a spectrum of 17 cancers

so what is that worth to BioNtech ?

Now the technicals and process of this is IMHO ... so i would welcome thoughts on it ...

what a ridiculous discussion coming from somebody who has Never made a technical appraisal of the science at all, so is not really in a position to adjudicate

this relentless filibuster that is ongoing from you Ruckrover just clogs up the BB with meaningless waffle. What are you achieving by it ? Are you the New ONW ?

I understand Einstein theory of Space Time Gazza /Ruck ... but i could never develop the idea .. you are coming at this from the wrong angle... normally to suit your trading position

By the way Ruck i left you with a question which you never came back on ... Funny that Tues 11.08

Ruckrover i don't claim i could do a better job ...

""""" And if you can't see that in some areas, on occasion, SCLP have been naïve then you are, well, naïve! """""

what occasion ? be specific .. otherwise its filibuster

sums it up nicely Boom ... and i agree with Wild ... Val is just smoke and mirrors trying to sell snake oil to the market