Member Info for inanaco

My Hot Cold posts on cancer

Herein lies one of the limitations of immunotherapy at present. “Only eight cancers to date are ‘hot,’” says Glimcher. “And even within those, it is a minority of patients who benefit.” Among the cancers generally considered hot are bladder cancer, head and neck cancers, kidney cancer, liver cancer, melanoma, and non-small cell lung cancer, as well as tumors of different types that have a genetic characteristic called high microsatellite instability.

The challenge, Glimcher says, is in applying immunotherapy to cancers that are immunologically cold, such as glioblastomas (the most common type of brain cancer), ovarian, prostate, and pancreatic cancer. “How do we make them immunoresponsive?” Glimcher asks.

IVY .. you are not representative .. in fact nobody yet has come out and backed you on that statement

"""Personally would prefer an open meeting where all feelings can be fully expressed and any anger gets out and then we can move on in a positive fashion rather than not being let out at all."""

as personally you prefer Anger gets out ... Ivy's AGM riot ... and i did say i would not continue ? why are you

they are all linked ...

as per Booms Post earlier ... in this RNS """including tumours with a particularly immunosuppressive environment."""

then if you think back to the Grand Challenge .. "hardest to treat cancers"

Modi1 has an incredible range of cancers it could reach ... 17 in all ... but it wont hit that 100% mark across the board so you have to take what boom posted earlier and start to consider why that is ...

"""including tumours with a particularly immunosuppressive environment."""

so this application of a different formed epitope in the same group is highlighting scancells ability to completely break down this barrier ... you just cannot imagine the wealth that this patent could generate

From sept RNS

The Company's second Moditope programme, Modi-2, is currently in pre-clinical development and is expected to address multiple cancer indications. Modi-2 will be the subject of new intellectual property applications with a view to extend the Company's dominant patent position in relation to post-translational modifications of cellular proteins and their application in the treatment of cancer.

From Placing RNS

Modi-2 targets multiple solid tumours (including oesophageal, gastric, colorectal, breast (non-TNBC), cervical, prostate, liver, renal, endometrial, bladder and thyroid tumours) and pre-clinical development of selected epitopes is planned during 2018. The Company expects to characterise its Modi-2 development candidate and begin GMP manufacturing in H2 2019. Both Modi-1 and Modi-2 will target tumours that are generally unresponsive to checkpoint inhibitor therapy. In addition, an international, multi-disciplinary team of leading cancer immunotherapy scientists in Europe and the US, led by Professor Lindy Durrant, Chief Scientific Officer of Scancell, and in partnership with Genentech, BioNTech and ISA Pharmaceuticals, has been shortlisted to the final stages of CRUK's Grand Challenge. Modi-3 forms a central element of the team's proposal with a focus on head and neck cancer, glioblastoma, lung, and pancreatic cancer, all of which currently have a poor prognosis.

patents

well like i said you have never been to a Scancell AGM and sat and listened to question after question on topics that cannot be answered ...(boom has never attended) because the BOD are abiding by the law "hiding behind protocols" for some unknown reason you seem to have placed yourself above commercial law .. it matters not that you feel you do not need to defend that, likewise Boom. but today Ivy went one step further ... "anger"
i will put it to one side ... as clearly the preference of some is .,.. brush it under the table.

The issue is, Scancell are not hiding anything, the problem is timing of announcement to protecting future patents, most of the work is in effect top secret, so we see the effect 18 months behind, so you have this missing window of what they are actually doing now

well you joined in last time with ivy indeed defending "hiding behind protocols" ...

your mate has gone wayward ..

told you before back bad posters is a bad idea

labour’s would-be Chancellor John McDonnell has refused to deny that he would ‘overthrow capitalism’ if Jeremy Corbyn made it into Number 10.

TalkRadio’s Ross Kempsell asked McDonnell this morning if he regretted previous comments, McDonnell responded by saying: “Not at all, I’m going to transform our economy”.

Personally would prefer an open meeting where all feelings can be fully expressed and any anger gets out and then we can move on in a positive fashion rather than not being let out at all.

I suppose TF and Boom will support that now ........

Baseball bats are banned

The Modi-2 peptide family

The Modi-2 peptide family is the subject of new intellectual property applications with a view to extend the Company's dominant patent position in relation to post-translational modifications of cellular proteins and their application in the treatment of cancer.

I do not really care, just wow ! scancell at 8p buy some ...... I did

was the reason a failure of the basics ... NO

fact your post was nonsense .... after all they did submit .. how can you argue with that ... ?

"Here" the website keeps crashing .. I predict . it will crash again ..

riding

You predicted a delay because

It was based on the fact that the IND had not been submitted and it was unlikely that they would get it submitted, approved and recruiting before the year end.

but the actual delay was the FDA asking questions after it was submitted

so after that statement .. you basically got it wrong , but by chance the FDA delaying the trial caused the same outcome

you are Ride the Crest by fluke ...

I predict one of these horse will win ...........

I predict most of these horses will not win ...

both statements are correct ...

I predict the trial will be delayed ...

when asked how .... i do not know ..

LOL but I will predict it anyway ...

But the IND had been submitted and it only takes 30 days that is on the FDA website ...

the only way you would have been proved correct is if you actually had insider information, and indeed did you sell all your shares based on that prediction ? because you would be sitting cash rich with the sp at 8p ...

50/50 was not relating to the % of the possibility of failure it was the flick of the coin thinking that seems to occupy this current thread

which is conveniently ignoring the actual prediction I made to start that thread, which was that the combi trial would be delayed to h1 2019.

that is not a predication it was a guess ......... back to this 50% chance of being right ..

this is your actual post

SCLPRE: Prediction9 Oct '18
please explain what is ridiculous?

i think it is perfectly reasonable to expect an explanation as to why the company is now two years behind on starting this trial. They have consistently said they "remain on track", yet just move the start dates.

Since the day they announced the trial, they have had two rounds of funding, both with the stated aim of financing the trial. As a shareholder, and someone who took above full allocation on both fund raisers, i think I am entitled to an explanation without it being "ridiculous".

Scancell has been subject to the development of the Tri grid 2 gun ... a Known fact
Scancell has RNS on potential dates based on estimates given by Ichor
Scancell has RNS subject to regulatory approval

at what point have you not been told ???