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"""" MODI1 is a mixture of natural(ish) citrullinated proteins, delivered in the hope of overcoming the tumours local immunosuppressive environment, """""

no its not correct ... it reads like we have sprinked peptides on the cancer ... leading to a natural T cell response

the mouse that did not receive the vaccine died, so could not be given a second dose of cancer

which would indicate no natural memory detected ...

so only the mice that responded to the vaccine ... responded to a second dose of cancer

thus Memory was generated ..

Ruckrover ...

Lindy has never presented it like that ...

"""so MODI1 is a mixture of natural(ish) citrullinated proteins, delivered in the hope of overcoming the tumours local immunosuppressive environment, spurring a natural T cell attack on the tumour."""

This is no offence to noise, but if that simplicity floats your boat why are you trying to present your self as technical ? because you just seem to want to cause conflict rather than any sensible discussion

its a known, why would i bother to write it out again .... ? Konar, just like when i discuss lindy's work .,.. it is not my work

Difference is in interpretation, i seem to understand what they are going on about ...

and i might add you are not posting on the subject matter or indeed replying to Rucks gibberish

you are posting jiberish

Moditope is NOT killing the cancer ......
Moditope is NOT modifying t cells in any """synthetic""" way

Moditope is setting off a NATURAL IMMUNE RESPONSE

its a natural extension to any adaptive immune response it builds over time, when you consider the bacteria or virus is replicating ..

1 x t cell would get a bit tired ...

so MHC 11 runs through the chain of events .................

Result CD4 cytotoxic T cells are NOT affected by PD-1 ligand

hope this all helps ... ATB

. Autophagy (macroautophagy) is a key player in providing substantial sources of citrullinated peptides for loading onto MHC-­II molecules to stimulate CD4 T cell responses. Stressful
conditions in the tumor microenvironment induce autophagy in cancer cells as a mechanism to promote their survival

CD4+ T cells with cytotoxic activity (CD4 CTL) have been observed in various immune responses. These cells are characterized by their ability to secrete granzyme B and perforin and to kill the target cells in an MHC class II-restricted fashion.

The main function of major histocompatibility complex (MHC) class II molecules is to present processed antigens, which are derived primarily from exogenous sources, to CD4(+) T-lymphocytes. MHC class II molecules thereby are critical for the initiation of the antigen-specific immune response.

Ruck i have just explained it better for you

If you have an immune response to cancer its will be a CD4 helper Cd8 killer cell ..

Cd 4 marks the cancer and attracts the CD8 to kill it ...

Cancer fights back with immune suppression like PD1 ... which turns off the response

This is all based on the CD8 seeing an MHC CLASS 1 molecule ...

The CD8 cannot see a citrullinated peptide as its a MHC CLASS 11 so does not know the cell is stressed

which is why you do not get a CD4 cytotoxic T cell naturally developing in the tumour environment

lindy Modi1 targets the Professional APC as this can deliver a MHC class 11 molecule to a CD4 T cell that has a similar profile to the epitope that the APC has ingested and presented it as a MHC class 11 molecule ... these CD4 turn into killer t cells also tuned to pro inflammatory by the adjuvant which is also digested by the APC

"""CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein.""""

B cell mediated response is antibodies ...

T cell mediated response is T cells ..

Moditope is a T cell response not an antibody response

Both B cell and T cell can engage in clonal expansion

The process, called clonal expansion, is what gives the adaptive immune system its extraordinary might and specificity. You can tell that clonal expansion is occurring when you feel tender bumps (swollen lymph nodes) in your neck or other areas.

When lymphocytes multiply during clonal expansion, some of them are destined to live on as memory T and B cells. These clones are a subset of the expanded number of T and B cells that develop from your first exposure to a germ, and they protect you against subsequent attacks by the same germ.

Because of this new population of memory cells, the responses to subsequent attacks are faster and greater than the first. This explains why once you've had an infectious illness, you don't get sick when you're exposed to it the next time around.

Ruckrover ...you just posted

"Is a simplified explanation that citrullinated peptides appears to drive an immune response with increased CD4+ T Cell count"
Yes, it improves the immune response as the CD4 T cells seem to want to attack it. I don't think it increases the T cell count.

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Then why don't they ? CD4's will already be in the area

I cannot do anything chap, not running Scancell happy that Lindy and Co are, which is why i keep buying

you seem to be getting confused ... BioNtech has raised funds for its own programs 270m

I suggest they have yet to raise funds to develop TCR Moditope etc.

Clearly they are well funded ... Clearly the science they have warranted that funding ...

which makes it interesting that they are still looking at Scancell ?

Stress in cancer like starvation or lack of blood flow as the tumour gets big causes cells to protect themselves, they can do this by citrullination

Cells that have citrullinated, if they come into contact with inflammation induced by cytokines can express the Citrullinated epitope

This epitope is what Moditope Vaccine is going after

So we tell the immune system with Modi1 to target this epitope but we also tell the T cell to produce more of that inflammatory cytokine this is what amplivant does it changes the type of T cell to pro inflammatory

the result, the T cell attacks this cell expressing the epitope and releases more cytokine that gets other cells to express the epitope ..

the T cells also multiple called clonal expansion ...

I am afraid so ..

Clearly you have not looked at the wealth behind BioNtech

In 2005, Andreas Struengmann and brother Thomas sold their generic drug firm Hexal (plus 68% of U.S.-based Eon Labs) to Novartis for $7.5 billion.

They have secured deals ... ? what is CRUK doing with SCIB2 ? why is BioNtech spending money on a major collaborative project with Scancell ?

Why are other institutions developing cancer vaccines with the immunobody platform ?

Why is the Karolinska expanding its mandate ?

They have already stated they feel that what is on offer at this stage was not good enough for shareholder value to be realised.

why sell out early for a few £1's when we know we can capture markets worth Billions in """"Revenue""""

name any other share that has this pipeline potential of treating the majority of cancers, way more than any PD1 product or check point can manage ????

Scancell is cutting edge ... delays don't exist when you have not done it before, they are Estimates of Time so should never be treated as black and white ...

You will always see a caveat .. "subject to regulatory approval"

Why are so many Top Academic Professionals giving the thumbs up ...

yet shareholder's moan ... its shareholders that took the SP down ... Buyers cannot