Member Info for HotblackDesiato

Potnak - thanks for the reply - isn't this a great board with so many helpful contributors!!

Hi Potnak,

Thanks for clarifying that a level of MTD is required (I have so much to learn!).

So do we then get into the scenario where, let's say, we've pumped 3 litres of the drug into the patient in 24hrs and they have no obvious side effects but trials show anything over 100ml of the drug in 24hrs has no additional benefit? Therefore MTD hasn't been reached but we've identified maximum efficacy for a given timeframe?

Damion - maybe they are waiting for news from elsewhere which they know will be due before 30th. If true, then they can't be holding back positive news because they don't yet have the news!

As for 'another failed attempt at MTD', is it feasible that the MTD is so high that they haven't yet reached it? After all, the definition is, "The most extensive exposure to a treatment that a patient may receive before he or she experiences unbearable side effects." If you drank 200 cups of tea in a day then the caffeine would probably kill you but who's going to drink 200 cups in a day? Failing to reach MTD is not always a negative.

Ahfam - when I was looking for info on the secret patent I did wonder if 'Crystalline Forms of a Pharmaceutical Compound' meant a pill but from my poking about on the web, I think it could perhaps also apply to liquid preparations e.g. salt crystals disolving in water.

Can anyone confirm if 'Crystalline Forms of a Pharmaceutical Compound' means the end result could only be a solid i.e. a pill or could it also mean a solution?

Sorry if this is a stupid question, my knowledge of chemistry is limited!

Metalbasher - if this goes to £30 a share, Monaco will be renamed Thoth-sur-Mer.

Whilst we speculate on what the patent might be for, it looks like we'll have to wait until early Oct. to find out unless the patent is granted before then.

The site https://www.mewburn.com/law-practice-library/uk-patents-the-basics states - "Eighteen months after the patent application was filed it is automatically published and is available for anyone to look at. This is not a granted patent and you cannot sue anyone yet for using your invention."

The patent was filed 7/4/20 therefore 18mths takes us to Oct 2021.

The site goes on to state, "Within six months of publication you must pay a further fee and request examination. During this detailed examination, the UK Intellectual Property Office may write to you giving reasons why the invention is not new or is obvious. You have a time limit to reply to the UK Intellectual Property Office’s letters and to persuade them that the invention is worthy of a patent. This often involves changing the description of the invention or the claims before agreement is reached, and this can take time.

When the UK Intellectual Property Office agrees that your invention is new and inventive, your patent will be granted. This fact will be published in the UK Intellectual Property Office’s Official Journal and you will be sent a certificate.

The process for obtaining a UK granted patent usually takes about four years from the date of the application.

However, if you pay some fees early and reply promptly to letters from the UK Intellectual Property Office, it may be possible to reduce this time to as little as 18 months, if your invention is not a complex one."

Gunner - I'm sure we'd all like to see an offer for the company but offers come in all shapes and sizes!

Would you sell up if a big pharma said, 'we'll take everything you have now for 20p a share'? Or would you rather wait until we have final trial results for all our wares and then accept, say, 10p a share because some molecules may have failed but £1+ if everything comes up trumps?

Are you feeling lucky?

Blastoid - I hope so! Clearly there are many hurdles to the success of any new treatment but Sareum appear to be on the right path.

As a slight aside, you might want to read a couple of books by Ben Goldacre, 'Bad Science' and 'Bad Pharma'. The world of pharmaceutical discovery is treacherous to say the least!

Not sure if anyone posted this back in Feb. when it was published but worth reading if you want to know why Sareum might be worthy of investment.

https://masterinvestor.co.uk/equities/stocks-in-focus-sareum-holdings/

As Thoth speculated on Sunday (15:51 post), "My guess is srra got an extension of 1 year (september) so we will see a move prior."

Hopefully Tim might have some sort of update for us before the end of this month.

The reporting algorithm thinks that any transaction just below the share mid-price is a sale even when it is actually a buy.

Sorry, I see my post is sort of a repeat of Utah's re interims - only just saw it.

As per the recent RNS, SAR will publish its interim results for the six months ended 30 December 2020, no later than 30 April 2021.

Do you think it's likely they will also issue a look ahead i.e. current state of play re 737/1801/1802/pending patents etc.? It wouldn't have to be via a RNS but maybe Tweeted with an updated list of things to come on their website.

New or prospective investors can find lots of info here: http://www.sareum.com/discovery/overview/

(Just thinking aloud)

I imagine those interested in reading patents will do their own digging but for anyone wanting just a cursory glance at things, you can see a list here: https://worldwide.espacenet.com/searchResults?ST=singleline&locale=en_EP&submitted=true&DB=&query=sareum&Submit=Search

For info:

The publication date is the date on which a patent application is first published. It is the date on which the document is made available to the public, thereby making it part of the state of the art.

European patent applications are generally published 18 months after the date of filing or earliest priority date. Prior to publication the application is kept confidential by the patent office.

The priority date is the filing date of the very first patent application for a specific invention. Within 12 months of that first filing, a subsequent patent application for the same invention can be filed claiming this "priority right".

I saw Charlie earlier on. He was kicking a tin can down the street and I asked him what he was doing. "Moving house."

'Nuff said.

Whilst not directly linked to SAR, it's good to see news from the AACR event filtering out to the media here.

https://www.theguardian.com/science/2021/apr/11/early-findings-show-new-drug-could-be-game-changing-for-brain-cancer-treatment

Ohhhhhhh! Maybe the secret patent is for a Hotblack Molecule! I like the sound of that - "...and the Nobel Prize for Medicine goes to Tim for discovery of the Hotblack Molecule."

Anyone else tempted to post a comment on the video along the lines of, "Hello Astra Zeneca, have you heard the one about the small UK outfit and some people at Sierra? Anyway, there's this molecule called...."

SOG - oddly enough, I was looking at that yesterday - https://clinicaltrials.gov/ct2/show/study/NCT02797964

Primary completion date was Oct 2019 but no results posted on the site.

I've been looking through related RNS for any mention of a 'get out' clause re handing/taking back 737 but don't see anything. Could this play into the hands of Sierra e.g. as there's no deadline for progress we're not giving it back yet so if you want it now then cough up?

Clearly a RNS wouldn't go into the minutiae of the contract but does anyone know if there was a deadline for progress clause?