Member Info for HotblackDesiato

Further to the speculation that the Gates Foundation might be behind the recent subscription, it would be reasonable to think if it were them, as part of their due diligence they would want to know everything that Sareum are working on. This would surely include mention of SRA737. If so, is it too speculative to think they would also have a word with Sierra and get things moving there? Either by providing funds or forcing Sierra to move it on to another party to take forward.

Just muttering aloud so please ignore if you think I'm talking rubbish!

Aye, but someone is bound to drop a rope ladder down the well Charlie's currently sitting in. He'll be back like a turd that won't flush.

I read an article that said 1 in 3 blokes is a complete tw*t. Though that only applies to Charlie if he's in a car with 2 other men.

Lazarus - was the 3m really a buy? Looking at the sp around 3pm it may well have been a sell.

With numerous variants on the rampage it'll not be long until the 3rd wave is viewed with an air of nostalgia.

Referring to the strains by their scientific designations like B.1.1.7 was deemed to be complicated so, to sidestep the problem of politically-loaded terms prevailing, the WHO has introduced the following new naming system:

Brazil variant (P.2) - Zeta
Kent variant (B.1.1.7) - Alpha
Indian variant (B.1.617.1) - Kappa
Indian variant (B.1.617.2) - Delta
US variant (B.1.427/B.1.429) - Epsilon
US variant (B.1.526) - Iota
Nigerian variant (B.1.525) - Eta
Philippines variant (P.3) - Theta
South African variant (B.1.351) - Beta

I hope therapeutics developed by SAR will intervene before the strain reaches the Omega variant (that's the one where it's mutated with Piers Morgan). Sleep tight.

Webstar - that doesn't mean to say 737 won't get a mention later today.

https://investor.sierraoncology.com/events-and-webcasts?item=58

Hi Utah,

Elon Musk is too much of a loose cannon for my liking - didn't he tweet his opinion a while back that Tesla was overvalued and the sp took a dive?

If you're looking for a long term, try Bushveld Minerals - CEO is a great strategist.

https://www.bbnbigbitenow.com/blog/categories/bushveld-minerals

https://www.thebushveldperspective.com/

Also Afritin (ATM) might be good. Do your own research yada yada yada.

Their CEO is giving a presentation tomorrow (Thursday) at 1:30 EDT (5hrs behind UK) so not too long to wait to see if SRA737 is still sitting in a drawer or not.

The conference is a virtual gathering of over 400 public & private healthcare companies and 3,000 leading executives, institutional investors, private equity investors & VCs will address near- and long-term investment opportunities and discuss the current trends driving healthcare in the U.S. and internationally.

You'd imagine someone might ask them about 737!

If you want to remain anonymous it's very easy - set up an offshore shell company and deal through that. Why bother setting up a shell in the Caymens or British Virgin Islands when Companies House here in the UK doesn't have the manpower to review every one. This is why there are plenty company directors/secretaries called 'M. Mouse' or 'R. N. Roll' etc. No one will ever be able to find out who is behind it.

I imagine every accountant has a few dormant shell companies already sitting in their drawer for when a client wants to go in that direction.

Shell companies are quite legal. What you use them for is your own business however if you end up in court you've only got yourself to blame....or your accountant.

Boris wants nothing more than British success. Imagine the tabloid headlines, "British boffins crack Covid! Yesterday two eggheads working in a shed announced etc. etc." They'd probably also try to describe them as plucky.

From a global perspective the UK is no longer the mighty nation it once was so Boris would be delighted if we could get one over on Johnny Foreigner.

Bit the bullet and sold a chunk of another holding to add another 479k here. Hope I've done the right thing!

Good luck all.

If so, then well played!

In other news, whilst I await funds being transferred to my bank this week (why does it take 3-5 working days?!!?), do I sell my other holding and throw it all in here this afternoon (expecting a 3pm MM tree shake)? Currently sitting on 1.66m shares but a few more wouldn't go amiss....

(Rumour has it the 10 mice are backing this all the way!)

Dr. Koi - not false reporting as such. Both elements of a Bed & ISA transaction get shown as sells rather than one sell followed by one buy. No idea why it should be this way but that's how a B&I gets recorded.

Rather than pitying and mocking our resident troll(s), instead we should perhaps thank them.

"Oi, Hotblack, have you been on the strong cheese again?"

No, and here's my thinking. Each time Charlie fires a shot across the bows we generally band together to rebuff their poorly executed toot by citing the science and the known facts. This bolsters our faith in our investment and the knowledge that it will come good - progress in the pharma sector takes time and we accept that. Sure, the sp might never reach the moon but a low earth orbit is quite achievable based on the various patents etc. etc.

Plus, I think I'm right in saying the day after Charlie pops up, the sp goes up. Hmmm, correlation or coincidence?

Makes ya' think, eh?

WIP - good work - it's a nice feeling having a fully loaded ISA.

I'll find out tomorrow what my endowment policy's final value is (phew, 25yrs gone already?!) then it's a long weekend of deciding how much I should add to my SAR holding. I'm already up to my plums in SAR so if it were all to go wrong it'd sting like hell. Just need to keep telling myself good news is on the horizon!

Once you're released from the shackles of work you can relieve boredom in two ways: stand outside your old work making rude gestures to those inside or try naked skydiving. Both are exhilarating in equal measure.

If you go to the presentation in the link below and look at slides 25 & 26, I don't see anything to suggest they have any focus other than on Momelotinib for the foreseeable funture:

https://investor.sierraoncology.com/download/2021.04.01+SRRA+Corp+Deck_external+version.pdf

Perhap they'll mention 737 next week....or not.

Thoth wrote a post earlier which outlined what sort of profit he's currently sitting on. Working backwards to guesstimate the number of shares he has, if this hits £1 a share then I expect his yacht will be so large that a few of us could stow away onboard and never be discovered. His only clue would be his stash of Wotsits would diminish rapidly.

I wonder if the heavily 'pro-active on SRA737' responses to any tweet Sierra puts out will nudge them into mentioning it next week at the Jefferies Conference. I imagine Sierra's media people will be tugging their CEO's coat a bit saying, 'uh, boss, we really should get a move on with this 737 stuff".

Anyway, more funds available next week to put in here. Just a pity I missed the chance to add at a discount!

Fax - I think I'm correct in saying the US military were looking into treating lupus with one of our compounds. Despite positive results, I don't think the trial was ever completed due to funding.

I'm sure someone can clarify if I'm wrong.

From New Scientist article 15/7/21 -

People who survive severe covid-19 appear to end up with a prematurely-aged immune system and other persistent immunological problems, which may be the underlying cause of long covid. The immune response to acute covid-19 is now well understood, but the longer-term effects are only just coming to light. The preliminary results from three studies looking into these long-term effects were reported last month at a virtual conference hosted by the UK Coronavirus Immunology Consortium and the British Society for Immunology. Together they suggest that the immune system gets a nasty hangover from the virus, but that it may be reversible.

University of Birmingham studied the immune systems of 46 people who had been hospitalised with severe covid-19. Three months after discharge, a significant number showed signs of premature immunosenescence: an age-related decline in the ability to mount an immune response. This included a loss of naive B- and T-cells, which are immature immune cells that have yet to be called into action against a pathogen. They also saw another sign of immune ageing: accumulation of memory B- and T-cells, which remain in circulation after an infection, ready to respond to reinfection. Additionally, there was also an excess of senescent T-cells, which can secrete damaging chemicals, driving inflammation that may underlie many age-related diseases.The subjects were aged between 30 and 68. Their immune systems were compared with a similar group who hadn’t had covid-19. Immunosenescence usually starts around age 60, but the survivors under 60 showed signs of it.

It isn’t possible to rule out that the survivors became severely ill because they already had prematurely-aged immune systems. Immune age varies widely between individuals; somebody who is 40 years old can have an immune age of anything between 20 and 60. Is it cause or effect? Probably a bit of both, as an analysis of people in the UK Biobank who developed covid showed they were biologically 10 to 14 years older.

A separate study at Manchester Uni looked at neutrophils in about 50 people who experienced severe covid-19. Neutrophils are general-purpose immune cells that patrol the body, destroying invading bacteria. They also promote inflammation, and are activated by viruses, including SARS-CoV-2.

About half of the people in the study survived - around a third had elevated and dysfunctional neutrophils up to 9 months after discharge from hospital. It is possible that this neutrophil imbalance contributes to long covid symptoms. For example, there is some evidence that neutrophils promote excessive blood clotting, one symptom of long covid.