RE: Point4 Jul 2022 10:31
Interesting bit of commentary from Point in their $400m prospectus re their FAP PNT2004 product.
PNT2004 is a fibroblast activation protein-a, or FAP, targeting program being developed for use in multiple tumor types. FAP is a 170 kDa membrane bound prolyl endopeptidase that is expressed during development but rarely in adult tissues. FAP is a compelling pan cancer target for imaging and therapy that is expressed in >90% of epithelial tumors. In cancer, FAP is highly expressed on cancer associated fibroblasts, or CAFs, which drive tumor progression and resistance to chemo and immunotherapy. We believe the lead compound of the PNT2004 program, PNT6555, has best-in-class tumor retention and normal tissue clearance, enabling delivery of large doses of tumor killing radiation