Member Info for HedgeHogarth

Lol, you really don't like hearing the truth Stu...I mean Hemotruth

As Bobby Brown once said...It my prerogative 👍🏻

You are probably Stu in any case so it makes little difference.

You derampers are so transparent

Well....I thought taking a break here with Stu would allow some room for some decent debate, but no...

The terrible twosome seems to have become the fcukwhiy four.

Usual negative patter to disrupt this forum - whilst they earn their few quid.

If any of you are unfortunate enough to get cancer or if one of your close friends or family get it. I hope you can live with yourselves given all the garbage, negative sentiment and manipulation of this board.

Think it may be worth finding a better way of discussing Hemo online without the unwelcome visitors. Here and Adfvn are a joke.

Every confidence that Hemo will shine through, but it deserves so much better.

Oh, final post, the answer to the question i asked you STU - Hemogenyx will get a telephone call from FDA with the decision when they are ready.

With due respect Stu, it is hard to take your post seriously - even when you use the term 'honestly'

Thank you for taking an interest in my health - I can confirm I am in tip top condition. I have my Hemogenyx T-Shirt on today and whilst tedious at times, fact checking your manipulative posts is not a chore at this hugely exciting juncture for HEMO

However, i will take your post at face value and kindly accept your olive branch.

Enjoy the break

The quality of discussion has been better today than it has for a while - following STU's point earlier, I am very excited that the "man from del monte" could say YES anytime.....

Good luck everyone - enjoy the ride :-)

Thanks for that Haywain - very encouraging

I was aware that HEMO was are no ordinary mice - I just did not explain it a fraction as well as you :-)

Saint - Point Taken

I was working on the guidance in the FDA literature which refers to the "typical length" and that it is likely to involved 10-20 participants

STU - I clearly referenced the RNS to support my view and yes it is an interpretation

However, unlike you, i did not have to 'doctor' the wording to support my view.

"take into TRIALS" is very different to what you posted. You posted "beginning of TRIAL" to try and suggest it only means Phase 1. That, my friend, is manipulation of the facts.

Hemo have £5m - they burn cash at less than that per annum. Phase 1 is a relatively low cost trial and take 'month' not years.

If Hemo felt they needed more to fund Phase 1 , they would have raised more cash in January than the £4m

Woodcot - what works in mice does not necessarily /always translate to working in humans.

However, #HEMO mice are no ordinary mice and I'd like to think given they were 'humanised' this improved the odds significantly that HEMO CAR-T will proved both SAFE and FUNCTIONAL on humans.

CAR-T for AML has not proved hugely successful yet - unlike ALL and lymphoma. The good news though is that there is huge amount of research and lessons learnt which HEMO will be all over.

The HEMO approach is more novel and targets a different antigen - many that have come before target CD19. It targets - whereas HEMO will target FLT3

Cyrox - more than happy to send you a Christmas card chap :-)

It may even be a posh one given the wonderful progress here at #HEMO

STU - for a change you make a really good point - It is very unlikely that the FDA will wait until Day 30 to communicate a decision.

It potentially shifts the timetable forward for me - I am now hopeful that we may get an RNS today, tomorrow or next week.

Glad my money arrived today :-)

STU - Given you are SO well researched (note my sarcastic tone)

You might like to tell everyone how HEMO will find out the decision?

I am still waiting for an apology for calling me a liar - I think you will find I provided all the relevant facts back to you to back up my position.

I look forward to adding Stu's latest thoughts on IND approval to his roll of honour - Nostradamus he is not

There are c600 active CAR-T trials - CAR-T is the most successful Gene therapy with 5 fully approved by the FDA after trials.

Having researched extensively myself - most clinical holds are either AFTER therapy/drug is tested on humans OR if the IND is sufficient in the level of data and analytics. NEITHER of these is a big risk - HEMO CAR-T has no human results yet and we know from RNS that a third party has already qualified the tests/analytics as meeting FDA requirements

In the, what I believe ,the highly unlikely scenario that a hold is placed temporarily - MOST holds are removed within a few months

https://www.biopharma-excellence.com/with-atmp-innovation-on-the-rise-sponsors-see-increase-in-fda-ind-holds/#:~:text=Data%20from%20the%20Food%20and,396%20original%20INDs%20in%202015.

VERY confident here

You cannot prove they are SELLS as much as i cannot prove they were BUYS

I would wager they are BUYS - MMs still happy to quote for HUGE sells

I understand Meeja

I hope he is getting well paid for having to confront someone like me who is honest, well researched, full of stamina and care deeply that this forum keeps to the facts and supports a balanced dialogue.

By balance, I like to see all posters present their honest views on the risks and reward.

There will be some BIG hurdles to overcome for HEMO down the line - only a minority of INDs make it through Phase 2 - about 33%. I'm very excited about CBR - however with ongoing proof of concept ongoing, there is no guarantee that it will make it to IND stage.

However, IMHO, the risk/reward ratio right now is very much in the favour of iHEMO and it's shareholders.

INDs dont tend to fail at either this FDA 30 day review stage (>90 %success)

AND

Phase 1 Trials (>70% successs)

AND

Combine those odds with a comparison of its vs Market Cap with that of its peers

AND

Combine that with its healthy Cash position of c£5m - having raised so successfully in January (at a time when other companies were struggling to raise)

Good advice JHFH - thank you

Time lines very clear as you say - just 10 working days now until HEMO almost certainly have the Green light to start trials

Exciting times

Looks like mostly all buys today though Pumps....

Sorry Jonnyr

But IF STU thinks he will get a free reign to spread his VICIOUS narrative and manipulative posts on here with any intervention he is sadly mistaken.

I care about #HEMO and will not stand for people on here making up lies and creating false naratives

I note that One2One posted about 10 minutes ago - the post has mysteriously disappeared. He boasted about his prowess of making money if Micky learnt him his shares. I did not think that was the typical activity of a poster who claims to work for DEFRA, not a 'money man' and is only here for the science

If LSE wont wake up and smell the coffee that these posters are making a mockery of this forum - then I will

I'd love to say "Good Try" Stu, but its actually really rather poor. It was not a LIE, it is my current belief on what i have read in HEMO RNSs and the FDA website.

RNS states (1) that directors have agreed they have cash for 12mths and (2) that it will allow them to progress into into clinical trials (PLURAL - not singular in your manipulative post)

As you can see, the FDA state that Phase 1 is a small phase and should take a number of months.

I'll make a note of your post and make sure it goes in the next update of your ROLL OF HONOUR

From 'Final Results' RNS:

On 26 January 2023 the Company raised gross placing proceeds of £4,056,250, which will be used to facilitate progression of the Company's HEMO-CAR-T product candidate into clinical trials and to enable the Company to continue development of product candidates for the treatment of viral infections based on its CBR platform.

Note the PLURAL "Trials"

and in same RNS

The Directors, having made due and careful enquiry, are of the opinion that the Group and Company have or will have access to sufficient funding in order to execute its operations over the next 12 months.

And from FDA Website:

Clinical trials follow a typical series from early, small-scale, Phase 1 studies to late-stage, large scale, Phase 3 studies.

Phase 1

Study Participants: 20 to 100 healthy volunteers or people with the disease/condition.

Length of Study: Several months

Purpose: Safety and dosage

Approximately 70% of drugs move to the next phase

Note the typical time scale of Phase 1

Phase 2

Study Participants: Up to several hundred people with the disease/condition.

Length of Study: Several months to 2 years

Purpose: Efficacy and side effects

Approximately 33% of drugs move to the next phase

Phase 3

Study Participants: 300 to 3,000 volunteers who have the disease or condition

Length of Study: 1 to 4 years

Purpose: Efficacy and monitoring of adverse reactions

Approximately 25-30% of drugs move to the next phase

Phase 4

Study Participants: Several thousand volunteers who have the disease/condition

Purpose: Safety and efficacy

You are lucky tbh STU - it looks like all the FY22 history of posts have been deleted as it only shows a handful of posts.

I challenge you to find 1 single POST in which i have lied.

You will not find a single one - i do not LIE