RE: Something big has happened10 Sep 2021 08:58
LOL!
PS. While I'm bored and further to my previous 'conspiracy theory' about the Oxilio delay somehow being linked to the data release for NXP002/NXP004, I noted the following article during a random search on tranilast anti-cancer properties:
https://www.sciencedirect.com/science/article/pii/S0753332221006260
It talks about the anti-cancer potential of Tranilast and how it might be of interest as a subject of re-purposing for oncology either alone or in conjunction with other treatments.
"Cancer is a life-threatening disease with a worldwide impact of 19.3 million new cases and 10 million deaths in 2020 [1]. Despite significant advancement in the treatment strategies made to date, life-threatening side effects induced by chemotherapeutic drugs, or the development of chemotherapeutic resistance limit the success of the treatment thereby causing therapeutic failure. [2] In lieu of this, active research is now focused on repurposing existing non-oncology drugs with low toxicity profiles for the clinical management of cancers. A recent study by Corsello et al. [3], has described the use of PRISM molecular barcoding and multiplexing screening method to test 4518 existing drugs against 578 cancer cell lines. This study reported that non-oncology drugs showed an unexpectedly high rate of anticancer potential and direct clinical translation [3]. Accordingly, it is postulated that drugs that target various hallmarks of cancers have better applicability in oncology therapeutics [4]. Since, inflammation is a critical hallmark that fosters multiple functions in cancer development such as immunosuppression, cellular transformation, promotion, survival, proliferation, invasion, angiogenesis, and metastasis [5]; non-oncology anti-inflammatory drugs may have an essential role in cancer therapeutics."
I thought it was interesting as Oxilio seem to imply on their website that their focus is on re-purposing drugs (plural) for oncology, yet they only mention OXL001 in their up-coming clinical trials section.
Could they have designs on NXP002 and/or NXP004 as well?
You could argue that this shouldn't have any impact on delaying OXL001. However, if the worst came to the worst and our IPF Tranilast data proved less than promising, it would put them in a rather advantageous position for further negotiations or full acquisition of NFX IP.
One would hope that a savvy CEO who has the best interests of the shareholders at heart would make it clear that any such delaying tactic might reasonably result in a re-evaluation of terms on OXL001 in the event of good data which strengthens our position.
What is good for the goose is good for the gander, so to speak.