Member Info for Dr_DMS

Hope they increase the divs as well, have you got a link?

Hope they increase the divs as well

Touka - suggest you go and read about half lives

Thorno - if there's no DOx in the plasma and none/hardly any in the surrounding tissues, then the amount going into the tumour is pretty much the amount you put in the body lol

Doesnt need to be told if it's obvious...!!

Timster, yeh i agree, seems to have been done is a subtle response to DB idiot which could be quite clever..

Even though P1 is a safety trial, the data conclusively shows that efficacy is there too, these are patients that are not recruited to prove efficacy and none was expected with the indications they have. Even pure dox had no response in many cases of prior treatment, whereas AVA6000 has, this demonstrates above and beyond that not only is it delivering dox straight to the tumour but the residency/half life is improved too.

The animal data was always expected as previous presentations have shown that there is much more FAP circulating in bloodstream in animals than in humans...thereby expected a much better response in the clinic.

The next phase will be the one where the data really becomes blindingly obvious to Joe public that it works, that's bcos the patients will be specifically chosen with indications that are responsive to the chemo administered, as well as the increased likelihood that the demographics will include patients that are much less advanced in their disease. e.g a higher proportion of stage 1, stage 2 than in the current P1 trial. Remember, these are late stage cancer patients that have no other choices, and even now they have stabilised the disease or actually reduced the tumor sizes now in a few cases.

All looking perfect in terms of how the trial and drug was designed, the worry really is over cash, as usual for any AIM company

Highly unlikely and IMO ridiculous to even suggest a placing when they have just paid the loan facility in cash.

Reason its tanking is bcos there has been absolutely no response from Avacta about the DB article, which is spooking investors that are not better informed! Probably exactly what it was designed to achieve...

Why would removal of BR ruin a lot of AIM companies?

In my mind it doesn't seem that a large proportion of PI's are about to pop their clogs and surely it's irrelevant to II's..

I would have thought putting stamp duty on in the budget would be much more damaging

Ah it's the stamp duty i was thinking of as dont seem to pay that on my small caps

Https://www.cityam.com/london-stock-exchange-boss-warns-aim-is-under-threat-of-collapse/

Even more reason to get onto NASDAQ....

What is the BR relief? is that to do with the fees you pay when buying a stock?

AVA6000 is far too crude? Why?

It's way better than standard DOx already!

As Dr Tap said "it becomes the standard of care overnight"

Its because the company doesn't communicate anything so the MM's don't make any money apart from with their wild SP swings, its a traders share now, not for investors. One day NCYT might need shareholders for another raise but will likely fail just like it did with Omega Diagnostics.

Synairgen is even worse, can go +/- 15% easily on a daily basis, same reasons, except i'd say they are pretty much done in terms of any future hope of making money, another loser for me during all the Covid "hype"

And you only buy and sell at the wrong time if you are lied to

Perfect example of the difference between Avacta AVA6000 and other trials. This GSK failed in P2 "Proof of concept" study, Avacta already have proof of concept demonstrated in P1....

https://www.proactiveinvestors.co.uk/companies/news/1055991/gsk-herpes-vaccine-fails-in-clinical-trial-1055991.html

I agree with pretty much everything that has been said, been invested for 4 yrs, made enough profit to pay mortgage off, but also lost my job at the same time due to Covid.

Shares plummeted then mortgage went from 4.5% to 8.5% and was stuck not being able to change mortgage due to lack of job. Caused me years of depression/misery/anger due to lies from government, then NCYT. Luckily, i was still able to pay my way with savings etc.

I'm working again now, and managed to get the mortgage back on 4% but still fully invested and just waiting to get out, average is about £2.30...

Same thing happened with many other AIM shares i still hold (CNSL/ODX, AVCT, HARL, RECO).

One thing i say is that ive learned my lesson never to invest in AIM again, its a circus show for keeping rich directors in their salaries for no return or care about shareholders.

Luckily i invested in large caps to which have offset a substantial proportion of my losses now and paying dividends, which is my strategy going forward.

Sometimes in life you need to learn the hard way i think, and learn from mistakes and move on

"The disease's recent outbreaks in non-endemic regions highlight the importance of global surveillance and the need for effective diagnostic and management strategies"

https://www.sciencedirect.com/science/article/pii/S2405844024133051

So 200,000 vaccines are being supplied vs a 10 million requirement and nobody knows if the vaccines work against Clade1!

I wonder if anyone does a test for mpox..?

About the lung cancer trial

Be happy with £3

I dont know why people keep voting them in and giving them big salaries, they do nothing for us, should have been voted out 2 yrs ago, need to get rid of them IMO. I cant wait to get out of this share, its totally depressing, the board are scum

Yeh true, hence why so many pension funds have abandoned UK. Politicians have a lot to answer for