RE: Interesting read1 Dec 2023 12:33
Thanks 5085 great research!
Heavy going but yes very interesting and here is the Conclusion:
“With the rapid advancement of novel therapies targeting the immune checkpoint pathway, there is a pressing need to develop better biomarkers to assess likely clinical response in advance of therapeutic intervention. Here, we report on a novel 3D genomics approach to identify predictive blood-based markers that can identify, with high accuracy, individuals that are likely to respond to PD-(L)1 ICIs monotherapy, especially across tumour types with low ORRs. The 3D genomics approach described here has been developed into a clinical assay to assist in treatment decisions, help improve patient selection for optimised treatment, help better utilise alternative effective treatments, minimise or avoid unnecessarily toxicity, and efficiently manage costs and resources.”