Member Info for D-Geeman

This afternoon I increased my holding by 50% but it only cost me 1/5th of my original spend on AGL. Fingers crossed for what happens next.

Hi Joe, it's not a law yet but it's actively being pursued: https://gallagher.house.gov/media/press-releases/gallagher-colleagues-reintroduce-promising-pathway-act-1

Https://www.congress.gov/bill/117th-congress/senate-bill/1644

'This bill establishes a provisional approval pathway for medicines intended for serious or life-threatening diseases, including illnesses posing a threat of epidemic or pandemic. The period of the provisional approval is for two years and is potentially renewable.

The Food and Drug Administration (FDA) must establish a priority review system to evaluate completed provisional approval applications within 90 days of receipt. A provisional approval application may be approved if the FDA determines that (1) there is substantial evidence of safety for the drug; and (2) there is relevant early evidence of efficacy, based on adequate and well-controlled investigations.'

Https://finance.yahoo.com/news/accustem-sciences-inc-emeritusdx-announce-110000007.html

AccuStem Sciences, Inc. and EmeritusDX Announce Joint Product Development Agreement and Strategic Partnership

LONDON and PHOENIX, July 17, 2023 (GLOBE NEWSWIRE) -- AccuStem Sciences, Inc. (OTCQB: ACUT), a clinical stage diagnostics company dedicated to improving outcomes for patients with cancer, and EmeritusDX, a rapidly growing cancer diagnostics and information company, today announced the execution of an agreement wherein both companies will jointly manage scientific operations and R&D for AccuStem’s product portfolio.

Initial plans as part of the collaboration will be to immediately focus on furthering the validation of AccuStem’s core offering, StemPrintER, for patients with breast cancer.

Story continues etc

' DM 'knew' he had a discovery. I don't think they are going to make any mistakes this time (although we shall see) '

True Xviolet with does cause me to wonder how DM made the grave mistake of resigning (whatever the circumstances) on the cusp of the return to Rukwa. Hopefully DM's 'loss' of not being CEO at the time of discovery is LB's 'win'.

Looks to be from HE1 themselves (not just a comment from elsewhere):

“…Helium One, which is looking for helium in Tanzania, will drill a proof-of-concept well by the end of the third quarter of this year…”

#HE1 yet again mentioned in the @MailOnline

'Well its over 80 on the rsi so a fall on monday more likely than not. '

Afternoon Wyn. I think you must be looking at the RSI with the 'month' period chosen and that's what you like to work with. But selecting 'week' gets RSI down to 70 or thereabouts. Since the drill acquisition update only arrived on Monday (so less than a week) might the 'week' period be a better indicator than the month on this occasion, leaving room for the sp to rise on Monday rather than more likely fall?

Wouldn't be surprised..

Must be a few people with their July 31st tax payment invested here. I would be surprised at a few sells around the end of the month. Doesn't mean more people, other people, would be buying of course.

It was proposed as a target price by Trek Madone, if helium were to be found by HE1.

He made a few predictions (which I noted down as Trek's a respected poster) and was posting on IQ-AI this week, though the price has some way to go there too. Here's the list from 10/7/21, so 2 years and 3 days:

'£5 here (HE1) in 2 years

50p at IQAI in 1 year

£5+ at TXP in 2 years

50p at CHF in 18 months

20p at CCZ in 18 months

10p at ECR in 18 months'

Https://www.reuters.com/world/uk/uk-scraps-public-disclosure-short-selling-2023-07-11/

Just copied the link from poster 'No Fear' on another BB.

If AVCT goes to the US soon one can probably forget about 'topping up on the dips' if that's important to you.

And in my own experience (TILS, ACUT and 4D) it doesn't always go quite as people predict either. Still, AVCT is a completely different kettle of fish altogether so who knows. Personally I'd rather it happen later than earlier.

Not certain this even refers to the posed question, but;

'Leveraging Cohort Management

Cohort management can be completed on an ad-hoc basis, but it is much more effective and impactful when it follows a procedure. Not only will consistent communication and planning help streamline dose determination, but it also enables a more effective staggering of patient treatments and minimizes downtime. This further ensures that data is regularly available for the cohort review committee and that dose determination for the next phase of research is simplified.'

Would appear that the the *option* to increase the early cohort dose does exist but isn't best practice.

https://www.allucent.com/resources/blog/effective-cohort-management-early-phase-oncology-trials

Allucent are in North Carolina USA, Bracknell UK and Netherlands.

Current uk clinical trials listed on the Sarcoma UK site. Hopefully the list will include AVA6k soon https://sarcoma.org.uk/clinical-trials/

Following some confusing comments on here recently I thought I should remind myself the purpose of each trial phase. This site is cancer research uk so presumably they know what they are talking about.

https://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/what-clinical-trials-are/phases-of-clinical-trials#phase2

The hike sounds very good Thorn. Have a good trip!

('The alpine portion of the GR5 long distance European hiking trail is without a doubt one of the most beautiful and personally rewarding multi-day hiking experiences in the world. Also known as a Grand Traverse of the Alps, this trail goes from Lake Geneva (Lac Leman) to the Mediterranean.')

Just spoke to neighbour. Had a fabulous time. He was away longer than I'd thought having left in October. Been to Bali, Oz, NZ and PNG. Obtained several diving certificates, been down to 40m, with whales and rays.. Other stuff too.

All this was possible by turning down chemo and other treatment. Maybe one day soon people will be able to have side-effect free chemo AND do all these things as a matter of course.

(No doubt someone on here will try to twist this post but reflects more on them than me.)

Teamin, thanks for that. Liver cancer not on the list so far as I can see so I will keep out of it.

Query for people with detailed knowledge of the trial eligibility criteria, the neighbour who went on 6 month world trip instead of accepting chemo treatment for liver cancer just arrived home.

Not looking too bad; carried a case from the cab.

Could someone with liver cancer get one the AVA6k trial? I think mid 60's in age and never had chemo. Lives not-far from one of the trial sites.

He also needs a liver transplant.

Is there any point in me telling him he should apply?

AS said at least a 50% chance of success. From the data so far, 50% doesn't seem to be stretching reality.

Maybe there's another catch but;

SP is currently 109p to buy. Not that shares would be completely worthless if almost all fails but let's suppose you'd lose everything.

So a 50% chance of losing 109p, and a 50% chance of turning 109p into.. 500p? 1000p? Pick your own figure but, on the face of it, anything above 220p and it makes 'odds' sense to buy AVCT shares – if it's money you could afford to lose.