Member Info for D-Geeman

I guess getting FDA approval is one thing but then AVA6k would still need to be 'prescribable' by NHS doctors and other State health services. Otherwise the market in the UK would only be to wealthy private people.

NICE The National Institute for Health and Care Excellence:

'We’re changing how we assess new drugs, devices, diagnostics and digital technologies to provide faster and fairer access in the NHS. The changes will also improve the way we work with patients, the NHS and the life sciences industry.

Here's what's changing and how to *tell us what you think* of our methods and process review.'

https://indepth.nice.org.uk/methods-review/index.html

*My emphasis. Looks like we are a month too late.

'Read the proposals and share your views

The public consultation is open until 13 October.'

The case of a-friend-of-a-friend has got me googling. She has stage 4 peritoneal cancer which started in her ovaries. She lives outside the EU /USA so has to pay for own healthcare over and above the very basic free ‘developing world’ healthcare that’s provided by her government. Her family have sold their house to pay for a new treatment (I don't know which one) which looked like it had put her into remission, only for the cancer to return quite recently.

Dox does seem to be a treatment for peritoneal cancer (though I haven't seen it on Avacat's list for the trial):

https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-3004-8

'Repeated intraperitoneal chemotherapy with cisplatin and doxorubicin applied as PIPAC may be an effective maintenance treatment in women with primary advanced, unresectable OC'. And google shows other references to Dox / peritoneal cancers.

But it'll be years and years before people would receive AVA6k licensed for peritoneal cancer rather than regular Dox; far too late for the woman I mention.

Made me wonder the chances of it being prescribed 'unlicensed' and found this:

https://www.gmc-uk.org/ethical-guidance/ethical-guidance-for-doctors/good-practice-in-prescribing-and-managing-medicines-and-devices/prescribing-unlicensed-medicines

'103 Unlicensed medicines are commonly used in some areas of medicine, such as in paediatrics, psychiatry and *palliative care*.' (My emphasis.)

So if AVA6K is licensed / fast tracked / breakthrough for STC, would it be possible for it also to be prescribed for palliative care in other cancers where Dox is a usual chemo? In that case and with safety more-or-less already proved, and some patients experiencing tumour shrinkage, who wouldn’t want AVA6k as a palliative drug, bearing in mind the guidance:

'106 When prescribing an unlicensed medicine, you must:

be satisfied that there is sufficient evidence or experience of using the medicine to demonstrate its safety and efficacy

take responsibility for prescribing the medicine and for overseeing the patient’s care, monitoring and any follow up treatment, or make sure that arrangements are in place for another suitable doctor to do so

make a clear, accurate and legible record of all medicines prescribed and, where you are not following common practice, your reasons for prescribing an unlicensed medicine.'

Time on site is 3.11pm. Could easily be putting things back together now and in time for news (or unexplained rise in sp) during market hours today.

Hard to do other stuff while this drama drags on..

'Avacat'

Joe, it's a sign..

(Daughters will be delighted.)

#Mainecoon £30

Even if HE1 don't tweet or RNS that the drilling has recommenced I'd be surprised if the sp doesn't rise at the time the drill can be seen / heard drilling by all those on the site.

I've 'OddBoxed' the lot of you...

Pasted the side effects twice but would certainly be an advantage if corticosteroids could be concentrated in the lungs and not the rest of the body.

https://www.mayoclinic.org/steroids/art-20045692

https://www.sciencedirect.com/science/article/pii/S0021925820407732#:~:text=Fibroblast%20activation%20protein%20(FAP)%20is,pulmonary%20fibrosis%20after%20lung%20injury.

'Idiopathic pulmonary fibrosis is a disease characterized by progressive, unrelenting lung scarring, with death from respiratory failure within 2–4 years unless lung transplantation is performed. New effective therapies are clearly needed. Fibroblast activation protein (FAP) is a cell surface-associated serine protease up-regulated in the lungs of patients with idiopathic pulmonary fibrosis'

I know a little about lung fibrosis (idiopathic pulmonary fibrosis) from family experience, & you get FAP in the affected lungs:

'Fibroblast activation protein (FAP) is a cell surface-associated serine protease up-regulated in the lungs of patients with idiopathic pulmonary fibrosis. We postulate that FAP is not only a marker of disease but influences the development of pulmonary fibrosis after lung injury.'

Treatment option choice is not great and includes steroids /

'What side effects can corticosteroids cause?

Corticosteroids carry a risk of side effects. Some side effects can cause serious health problems. When you know what side effects are possible, you can take steps to control their impact.

Side effects of corticosteroids taken by mouth

Corticosteroids that you take by mouth affect your entire body. For this reason, they are the most likely type of corticosteroid to cause side effects. Side effects depend on the dose of medication you receive and may include:

A buildup of fluid, causing swelling in your lower legs.

High blood pressure.

Problems with mood swings, memory, behavior, and other psychological effects, such as confusion or delirium.

Upset stomach.

Weight gain in the belly, face and back of the neck.

When taking corticosteroids by mouth for a longer term, you may experience:

Problems with the eyes, such as glaucoma or cataracts.

A round face, which is sometimes called moon face.

High blood sugar, which can trigger or worsen diabetes.

Increased risk of infections, especially with common bacterial, viral and fungal microorganisms.

Bone fractures and thinning bones, called osteoporosis.

Fatigue, loss of appetite, nausea and muscle weakness.

Thin skin, bruising and slower wound healing.

What side effects can corticosteroids cause?

'Corticosteroids carry a risk of side effects. Some side effects can cause serious health problems. When you know what side effects are possible, you can take steps to control their impact.

Side effects of corticosteroids taken by mouth

Corticosteroids that you take by mouth affect your entire body. For this reason, they are the most likely type of corticosteroid to cause side effects. Side effects depend on the dose of medication you receive and may include:

A buildup of fluid, causing swelling in your lower legs.

High blood pressure.

Problems with mood swings, memory, behavior, and other psychological effects, such as confusion or delirium.

Upset stomach.

Weight gain in the belly, face and back of the neck.

When taking corticosteroids by mouth for a longer term, you may experience:

Problems with the eyes, such as glaucoma or cataracts.

A round face, which is sometimes called moon face.

High blood sugar, which can trigger or worsen diabetes.

Increased risk of infections, especially with common bacterial, viral and fungal microorganisms.

Bone fractures and thinning bones, called osteoporosis.

Fatigue, loss of appetite, nausea and muscle weakness.

Yes, spray tan, or recently returned from sunny Tanzania :-)

They removed the word Gullible from the latest OED as it was so little used for 5 years...

I took the hint in the tweets to be the tweet itself; an exercise in hand-holding to show that nothing untoward had happened and still drilling away happily. Probably prompted by the jitters in the sp on Friday (people wondering what bad news, if anything, had leaked) upon which I de-risked myself a little, albeit briefly as it turned out.

The moon is pretty visible atm; just over half moon and waxing. If it's the moon in the pic it looks a bit small and I did wonder if it's a bright planet being exaggerated by a poor camera at dusk but if others also think it's the moon then likely the photo is current.

I looked for camera metadata in the image (having saved it) but X must have stripped it out (or HE1 stripped it out before posting). There's no info at all.

'Can't remember DTW suggesting it would be overnight'.

The markets are closed for a start.

I just used the 2/3 of the money I received (selling) on Friday to buy back.

Quick PS Mjapac,

I immediately sank 1/3rd into another share I hold and which also fell today but the 2/3rds is sitting in cash and might well go back into HE1 whatever the results of the current drill.

If the news is good then I might jump back in at a higher price with less risk. If the news is bad I might jump back in for the second drill and with roughly the same number of shares as I held yesterday.

Mjapac, yes of course. I'd added to my holding with 6p offer and at 4p when the drill broke so that it was bigger than I want to risk. My intention was always to sell some before the results and hopefully at a profit with a rise at spud and as the drill proceeded. If anything I've held it longer than intended as the sp didn't rise as it did last time.

I was doing dummy sells around 6p yesterday but then sp fell back, market went haywire, and I'd hoped for a chance to sell for more today. It just didn't come.

I lost quite a lot on eve sleep plc last year, and on other things 4D etc.. I can't afford to do the same again. Just risk management I guess. My wife thinks I'm a gambler / bonkers for selling HE1 at a loss but it actually seemed the most logical course for me right now.

If the shares go above 10 or 11p I'm in profit again ; perfectly possible (more than likely) on good news.

I did look and there isn't a Saint Lorna but there is in fact a St. Blaise! Was a man but maybe he will put in a good word for us! (not that I'm a believer that kind of miracle.)

Me too I'm afraid, late afternoon. Sold 1/3rd of my holding, some at a profit and some at a loss.

Decided that what remains will do well if they hit helium, and I live to fight again if it's the alternative. A bit of me also feels that success is now more likely, just to spite me.

My sell is showing as a sell.

I suspect it'll be easier to keep news on helium discovery – or not – under wraps for longer than the drill breakdown / stop which would have been pretty obvious, even to a blind person, at the site.

Hi Ant, my spelling mistake! Or just maybe 'auto correct'. Defo UK passport :-)

I do have a bottle of whisky in the cupboard. Oban 10 year old Single Malt from a trip we took including a distillery tour, more than 10 years ago, alas still not opened...

Tend to drink a beer myself, usually bitter / IPA :-) Or red wine.

So I guess I am more with Latorre when it comes to my tipple!

We should all have a toast to our success if this drill result pans out as we'd wish for. I'm really not holding my breath, not taken a chance to de-risk so ought to be more anxious than I am. I take comfort from the fact that it's not gone the way of last time, so far.

All the best to everyone.

Wyn, crossed my mind yesterday that you once mentioned a favourite tipple of your is whiskey.

Maybe rum too?

W hiske Y a ND RUM ??