Member Info for D-Geeman

The stock markets today are up generally so could be that the MMs lift the price stocks like AVCT too, if there's not much between buys / sells today.

‘Sold a bean’ :-)

‘Maybe he should question why people have such a low opinion of him.’

Depends on the people who have a low opinion of him surely? I suspect W2 has a low opinion of me but looking at her history I am obvs not bothered. Maybe wyn isn’t that bothered at the people who have a go at him as they don’t have great track records.

‘By the way, at one point I was £45k up on BMN.’

I was up a huge amount on SNG, quite a bit on AVCT and TILS, and even Eve sleep at one point. Unlike wyn I never sold a been until it’d all or mostly gone.

So now I listen to wyn’s thoughts despite the criticism. I’m actually doing a bit better as a result - so far anyway

Worth checking on poster’s past performance I always find. But thanks for your opinion Cinderone.

Cindercone

Posted in: BMN.L

Posts: 2,043

Price: 24.10

No Opinion

RE: Paranoid10 Jul 2018 14:09

Indeed, my recent clash with Ophidian has seen more posts removed. I cannot prove who is removing posts, therefore cannot apportion specific blame, but it definitely stinks. There also appears to be some form of SP manipulation going on, with artificial boundaries being created by LT holders to peg back the price. Please note, for the sake of not wanting to drag the board down with more argumentative drivel, this accusation is NOT specific to anyone on this board.

The good news is, nothing will stop this share regardless, and the few posters we all rely on to provide excellent information continues unabated and remains a blessing

Vertizea, son, No, no connection with cancer. BUT they do illustrate that one good result can be used to generate publicity for a new treatment in the US, and also the effect of moving to the Nasdaq which seems to be going ok. People are well aware of others who've gone to the Nasdaq and failed. Obvs the jury is still out with TLSA but today's news is a good sign. Alzheimers is a huge market too of course.

I doubt my post will influence the sp of $TLSA when it opens but I'm always happy to share positive news.

Quite a few folk on here used to follow TILS before they moved to the Nasdaq. Report me by all means but they are blowing their trumpet quite often on the results from a single patient.

Https://finance.yahoo.com/news/tiziana-life-sciences-announces-immunologic-110000484.html

Https://finance.yahoo.com/news/tiziana-life-sciences-announces-immunologic-110000484.html

NEW YORK, July 21, 2025 (GLOBE NEWSWIRE) -- Tiziana Life Sciences, Ltd. (Nasdaq: TLSA) (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies with its lead development candidate, intranasal foralumab, a fully human, anti-CD3 monoclonal antibody, today announced compelling immunologic findings from the treatment of a moderate Alzheimer's Disease (AD) patient with intranasal foralumab.

Transcriptional analysis of white blood cells before and after foralumab therapy revealed profound immune modulatory effects. Significant changes were observed in CD4 cells, CD8 cells, and monocytes, underscoring the broad impact of nasal foralumab on immune cell profiles. These results are consistent with improvement in microglia PET scans conducted at the time of immune analysis which demonstrated a marked reduction in inflammation following nasal foralumab (Clin Nuclear Med) showing a link between immune effects and resolution of brain inflammation.

In an unexpected discovery, the analysis revealed an increase in phagocytosis markers in classical monocytes, suggesting that nasal foralumab may enhance their ability to clear amyloid plaques. This unexpected effect may open new avenues for treating Alzheimer's Disease by targeting both inflammation and amyloid accumulation.

Dr. Howard Weiner, Co-Director of the Ann Romney Center for Neurologic Diseases at the Brigham and Women’s Hospital (BWH), a founding member of the Mass General Brigham healthcare system, commented on the findings: "The observed reduction in microglial inflammation and the unique immune changes seen in this Alzheimer's patient treated with nasal foralumab are highly promising. This study represents a step forward in understanding the potential therapeutic role of foralumab across neuroinflammatory diseases."

Ivor Elrifi, CEO of Tiziana Life Sciences, emphasized the implications of these results: "We are thrilled by the outcomes of this immunologic analysis, which demonstrate for the first time in Alzheimer's Disease the profound immune modulatory effects of nasal foralumab. Beyond its established benefits in other conditions, such as Multiple Sclerosis, this study suggests that nasal foralumab could offer a dual benefit of reducing brain inflammation and potentially influencing amyloid pathology."

Furthermore, the treatment was well tolerated with no reported side effects. Encouraged by these results and the observed behavioral improvements reported by the patient's family, the patient and his wife have chosen to continue nasal foralumab therapy for an additional 6 months.

(I was writing this but now see Wyn's replied.)

I think I must be the only person who actually *reads* wyn's posts.

He wrote this is reply to me on 18th, so only Friday.

'So far according to the chart this is still a good entry point. so the market currently is looking for the SP to rise from here. '

Not that I did anything about it then. Who knows what wyn did.

No trades showing as I look at 9am so hardly a stampede in either direction.

And 'If you hear hoovers', it could be Dysons.

Thanks for your thoughts wyn, very interesting.

Atb, D

Wyn, 'Zeus or clients of Zeus', bought at 30p. People in Zeus and AVCT must have known that this would push up the SP.

What if they'd bought a lot more and we haven't been told yet (if that's allowed). Presumably they could afford it. Or could they have secured an undertaking to get more at 30p next time, whatever the SP then?

Or perhaps they don't know more than us and they are just dipping their toe (a big toe nevertheless).

If they'd bought more than enough to pay off more of the Heights CLN then they could've really got the SP up. Why not do that? It would've been in their interests too.

I am just wondering why they would spend £3m and push the SP up so that next time they'd have to pay more. Or perhaps they are 'done'.

Thoughts anyone?

'Buy at 30 sell at 33 = quick 10%.

Never heard of the bid offer spread? '

Buy in the raise at 30, sell on the open market at 33. 'Even I' knew what Bella was implying...

You're not wrong there Vertizea, son.

I also nearly mentioned the Ilika RNS to wyn (and you I suppose) but decided not to. He'll know about it anyway.

I also nearly wrote a quote from CJ (Reginald Perrin boss) along the lines of "I didn't get where I am today by being desperate and deluded" but decided against that too.

Not a bad day watching2. Doing my annual accounts, then I cleaned out the fish tank, and then took daughter to Nationwide to open her first account. They were thrilled to see us 5 mins before closing.

That fairer sharer £100 'gift' at Nationwide is a bit strange. One daughter got it last month and the other didn't (even though they have the same accounts and similar balances) so I'm making a complaint.

Talking of un-answered questions; 'France', for me.

'Watching2

Posts: 8,952

Price: 32.50

Interesting to see where we will be at Christmas!

Gl

J'

If they’re on the cusp of good trial news, then they’d want it out before the CLN payment due date, surely. Which may be accounts for today’s rise, people betting that good news is imminent. If there is no good news to be announced before the CLN then it’s unlikely to be ‘just around the corner’.

Having said that, if they don’t issue good news before the CLN and then do issue it immediately afterwards, there’d be quite a few disgruntled posters on here (and a few happy ones who bought on the dip).

You know what CJ, I'd rather not talk to you again. You seem to be too much of a hypocrite all around your life. And a fantasist too.