Doxorubicin Liposomal (Doxil)2 Oct 2021 20:05
I wonder if the drug companies are planning to boost the production of generic Doxorubicin. Would be ironic for AVA6000 to work and the not enough Doxil to go with it and meet a hugely increased demand.
(D-Geeman; member since 17th Sep 2018 and so presumably not NDN, Ray, or wyn – despite claims accusations that I am)
https://en.wikipedia.org/wiki/Doxorubicin
Shortage[edit]
Between 2011 and March 2014, Doxil was in limited supply.[43] In 2011, Doxil became available only in very limited supply due to production problems with the third-party manufacturer. Johnson & Johnson (JNJ), through its subsidiary Janssen Products, LP, had been receiving its Doxil supply from contract manufacturer Ben Venue Laboratories (located in Bedford, Ohio), a unit of Boehringer Ingelheim GmbH of Germany.[44] The problems began when Ben Venue temporarily shut down their manufacturing facility due to quality control issues.[45]
In February 2012, to address the Doxil shortage, the US Food and Drug Administration (FDA) allowed for the temporary importation of Lipodox, which contains the same active ingredient as Doxil and is made by Sun Pharma Global FZE (Sun), a subsidiary of India's Sun Pharmaceutical Industries Ltd.[46] The agency said it intended to continue allowing the importation of Lipodox until Sun had made enough generic Doxil to meet demand.[47]
The FDA approved the first generic version of Doxil, made by Sun, in February 2013. It will be available in 20 milligram and 50 milligram vials.[48]
And:
https://pureportal.strath.ac.uk/en/datasets/data-for-rapid-scale-up-and-production-of-active-loaded-pegylated
Manufacturing of liposomal nanomedicines (e.g. Doxil®/Caelyx®) is a challenging and slow production process based on multiple-vessel and batch processing techniques.