Member Info for ColdFishPie

Its decissive action so will give then a pat on the back for that. But we need more committment from the bod. Hoping that they are getting this one out the way then in time for the conference call they rns a freezing of salary costs and further cash saving initiatives. Lets see but i think they will.

Fair enough....so where is the statement to say the the bod will suspend their salaries until the fda concludes their final assessments? If they are going to manage cash aggressively, this is the quickest way to do it surely!

After this debacle, i will certainly stay well clear of anything that has to go through the fda from now on. A rejection or lets say a non approval might be a better way of putting it is one thing but why all the secrecy. Company suggesting full fda guidance all the way, priority status, no add comm and you end up in a situation like this...and what makes it worse, our own bod shut up shop. Its high treason i tell thee:)

Thanks for posting vascular. My take from that is the bod are keeping their cards very close to their chest with regards to how significant this problem is then!

His name was matteus or something like that.

Ian....some guy on twitter said that but i will believe it when i see it. Funnily enough, the yank investors on twitter are loving this and some are bumming away of how they have made 200k dollars in a single day, maybe they have a bit more info over that side of the water than we have here. Nothing would surprise me.

Dont know what the core funding is but they only have about 8 staff and are spending around 1.3 to 1.5 per month. A lot of that will be on cro's for cystic fibrosis work i expect but if this going to take a considerable amount of time...they really need too look at preserving cash asap. Anybody have any thoughts on the european submission then? This has really recked the whole thing up...even if they do manage to get approval in a year, its still a mess and im struggling to see any value in it now. Maybe over thinking it but can then see a need for more money, then more money, then another problem.

My vote is for the bod to start taking their salaries in shares each month...we have suffered so they should align themselves. Most of them are millionaires anyway...if they are shocked by the crl, they should try having hard cash in here when you dont have much! Then they would know what shocked really means:)

Hi hanibal, Ivy pointed out some research that this only applied to about 2% of the trial population so it would not have such a big detrimental effect as you would think. If it is just a labelling issue and that were the case, then i think everyone would be more than happy with that. Thats the problem just now, nobody knows and maybe mtfb dont until after the meeting....but given the nature of whats happened to the sp and its effect on peoples finances...things should be clarified urgently or they are only making matters worse from an already disasterous situation.

Yes, if ever there was a black swan event that proves you should never use stop losses...then this was it! Can a guarenteed stop loss work in cases like this....i cant see how?

Or how about a big pharma who might want the lot if approved. They put 25m up front without any security and they can have the whole lot for another 150m if approved, the problem with that is shareholders have to approve when formal offer is made but i would take a deal along them sort of lines:)

Grants are available for sure but they have to be applied for when listed. There is no way any government wether u.s or uk would issue mtfb any monies so that they could get their drug approval over the line. That said, a philanthropist like bill gates and his foundation might help but i doubt it...might cause too much grief. If a lot more money is required and there is still too much uncertainty then i think motif should try a farm in with a well financed pharma...you might have to give up quite a bit but there could be value in doing it if the sp is depressed to a degree wherby the raise would cause too much dilution....meaning a well financed pharma might be willing to cut a deal on far more favourable terms than a placing for a slice of the cake...plus it would produce less volitivity in the sp.

Yes ivy...that would be good. To be honest, i would prefer it if mtfb have made an error in their submission and they have the additional data needed.....while that might be quite galling and time consuming, we could live with that. However, if they dont know the exact issue, even before they meet with the fda, i would hope that they employ some of the best consultants in the business to be reviewing every factor of liver tox info they have against every other piece of info against all drugs that is effected by liver tox, they need to go into that meeting very heavy handed or they have no chance imo. Ofcourse vany is the main comparator but it sounds like there is little difference so how is a wider subset going to prove much!

Sounds grim to me...if you only get 2% out of 600 and you dont know who until the trial starts. Maybe the fda will set the criteria that we need a subset of 100 for a true data analysis so we test a further 10,000:) No...i think thats how you get to game over very quickly! One thing, if mtfb cannot proceed they will have to try and sell the I.P. to cover their debts and wined the company up...by that time there is likely to be a lot bigger disparity between cash and debt so they will be forced into a firesale....it will be interesting to see who gets it and follow their path for a while:) My guess is they will be american and they will come up with a new novel way of getting the data and hey presto...approved!

No correlation between the markets imo. American investors are not usually arsed about stocks who have their main listing on lse so a little volume can sometimes mean big % rise or falls over there...ive noticed that on a lot of small caps with dual listing. It is strange when you think of that level of difference though because in the event of a takeover, that would come into play.

Ivy, very well researched. The problem is if the same results come back from the subset will it get approved? Do they really think it will be a different result and in all the other trials completed...there must be a raft of more data available. Its disgusting from the fda that this is not clear or has not been made more clear during the trails. Is this it, can the fda move the goalposts whenever it suits them, does 15 years of trials not mean anything or have motif made a huge mistake here? Somebody has got something badly wrong and no-one is as yet taking any responsibility for it. The bod are cowards in my opinion if they do not follow this up with a comprehensive update regarding the information that they hold and why they believe that it was adequate for submission. They owe this too their shareholders as this failure has had a catastrophic effect on their wealth and will probably have a detrimental effect going forward with the major holders selling all they can...institutional investment is supposed to be a good thing so what does it say when they dump so heavily. They also owe it too the market to clarify their position....hiding behind the smokescreen that if we say anything we might upset the fda and it will cause approval problems going forward does not cut it. I think we can safely say that this has done so much damage to the companies chances of survival and its investors position that for them not to say anything is an abdication of responsibility.

I dont think we should give anything to these telematic companies...bin them, their nothing but cheats who are out too screw see over!

Lewbo...if you check my history further back you will see that i have been invested in see a lot longer than my investment in mtfb and with about 5 times as much. I also had a previous user name that i dont use anymore or i could demonstrate that i was posting on this board back in 2014. Whatever but it still does not take away the fact that im not happy with progress, concerned about the bod's attitude toward us and worried that we will have a deeply discounted placing for a lot of dilution...well below my average. So my beef too the bod, start performing and raise our profile up as a matter of urgency before you start giving mates rates!

Its past the point of frustration bb...its more of a concern now dont ya think. When the bad news started last july that was frustrating because with it you soon realised that the road is not as smooth as you would have hoped and the sp was dropped on a weekly basis. But since there has been nothing but lets say poor news and we are being left too rot...i nearly threw the towel in at 4 and glad i did not ofcourse but i dont fancy another big placing in the 4 or 3's either. When is this company going to at least brighten the mood a little?

That they have mentioned eviking.....lets not forget that they consulted with 3 fda liver specialists. Somethings not right.