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250 replies... Just stop it. Have you nothing better to do with your time?

No, it is 2 doses with a 2 week observsation period at the end, so 4 weeks per cohort. Period. That is the safety aspect for the SDMC to assess and approve esclation to the next dose level.

Tumour assessment (imaging, measuring) is carried out every 12 weeks (i.e. 6 cycles) for as long as there is no disease progression. This is for the efficacy aspect.

"Going for Christina's presenting skills is about as weak of an attack line as it gets" - and not only that weak attack (which it took him several days to come up with as hIs BEST😂😂😂 line of attack), he also mistook the prepared presentation he watched for the live presentation at the AGM.😂😂😂 🤡

Talk to my a$$ Eggy cos the face ain't listening. You are a clown, an idiot and a complete waste of space. Eggy Soldier🤣🤣🤣

Only to call him a moron Timmy. NEVER engage with his drivel.

🤡, your drivel is not even worth reading.

SandyR, you can't reason with the unreasonable, and it's only fools who tolerate the intolerant or try to educate the willfully ignorant. Just call them out for what they are, in the strongest language you chose to use. People like Eggy, Windbag and Touk are vermin and should be called out as such.

Nah, Eggy Thorn just needs to shut the f up and f off. Anyone who hasn't binned that ignorant twunt is also an idiot.

"I'm not sure they've done a great job it setting themselves up to achieve that."

So you're a professor of Pharmacology now Eggy, eh? Or is it Oncology? With your professorships in Virology, Epidemiology and Infections Diseases you must be quite a catch for some Big Pharma company, 🤡

Shades of Crocodile Dundee/Donlad Trump there bella?

Could someone who was at the AGM please explain how the voting was done? If it was on a show of hands, had you earlier declared how many shares you were voting with? Did you hold up a card with the number of shares on for example? What was said about the number of proxy votes and how they fell For/Against/Abstentions?

It all seems very fishy the way the voting has been described so far and whilst there may be no obligation to report the votes For/Against/Abstentions, a public company must at least be required to record the votes? Surely?

Very kind of you Geordie, thank you. Make mine a scotch.

I understand you are deeply underwater Aldebaran but opinions, even honest ones, are like..., everyone has one.

Que sera sera

-5

No Bella, I wasn't. I was thinking of the other end, the leaving group, 5140 (really AVA5140?) for AVA6000. I can't remember what the AVA3996 leaving group is called but it was shown and named in a presentation last year.

Anyway, you know that AVA3996 used to be called ARI-3996 and AVA2727D used to be called ARI-2727D when Bachovchin synthesised them, tested them and patented them? https://patents.google.com/patent/US9597410B2/en

A couple of years ago Alan gave a list of pre|CISION drugs that had been synthesised and tested but nothing more was said and no IP came of that. I wonder what leaving group(s) was/were used and what the invitro results were like.

Pre|CISION has been proven to work in that the R-(D)Ala-(L)Pro---warhead linker is selectively cleaved by FAP in the clinic in the case of AVA6000 and AVA3996 is showing the same cleavage behaviour invitro and in animal models as AVA6000 did, but ask yourself this: why do AVA6000 and AVA3996 have different Rs in the leaving group?

All true but AVA600 does have the value advantages of a much faster time to market and already (OK, soon) being proven.

Are the voting results published anywhere, particularly #2: 'To approve the remuneration report contained within the report and accounts for the year ended 31 December 2023'?

It's normal to publish the numbers of votes cast for and against each resolution and the abstentions isn't it?

If you were that concerned, did you go to the AGM to ask the question?

If you didn't, then just bore off.

It's a bad online day today . On/in. Traders not day traders