RE: New Affimer Paper (3 September 2021)3 Sep 2021 17:47
'Overall, Affimer 780A represents a first-in-class selective binder for EPAC1 for use in biochemical and cell
biology studies of cyclic AMP signaling. Future work will be aimed at improving the affinity of Affimer A780 towards EPAC1 through selective mutation of the Affimer binding site and also generate Affimers to the N- and C-termini of EPAC1. By improving the affinity towards EPAC1 and identifying further interactions sites we hope to extend the usefulness of EPAC1 Affimers for fluorescent microscopy and other applications, including modulation of EPAC1 activity and intracellular targeting.'
Funding: This research was jointly funded by Medical Research Scotland (grant number: PhD-868-
2015) and Avacta Life Sciences, through a studentship awarded to H.K.B. U.L.S. was a British Heart
Foundation research scholar (grant number FS/17/12/32703). B.V.B. was funded by a James Watt
Research Scholarship, funded by Heriot-Watt University.