Member Info for Basser1

https://cancerres.aacrjournals.org/content/80/16_Supplement/450

A recent scientific paper (Aug 2020) on the combo of a BET inhibitor and SRA737 published at the AACR conference. Promising findings on the treatment of osteosarcoma ( bone cancer).

RMM. Nicely put. It is clear to me that the combinations with SRA 737 are staying in house. Sierra has always been ambitious in becoming a major pharmaceutical and this hopefully is a step along the way to just that.

Remember John Readers comment on SRA737 research update re being potentially able to treat half of mutated solid tumours. Well AZD5153 was in a combo trial for treating solid tumours. Not a coincidence.

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwiVnejV4ZryAhVBr3EKHSOnAQsQFnoECAQQAw&url=https%3A%2F%2Fichgcp.net%2Fclinical-trials-registry%2FNCT03205176&usg=AOvVaw2Nh49lnxNaLwZzKMylKAocAZD 5153 was in a combo trial with Olaparib to treat solid malignant tumours. Looks to me like they are going it alone with a AZD5153 and SRA737 combinations

https://youtu.be/TYIl6n_SRCI

Maybe nearing an appropriate time to look at how best to avoid the taxman. Great song.

Just gone to 8.80. Mopping up any share around 8.55. New buyer?

Aber - my reply gone as well! It doesn’t matter, the fact that Tim and John have not exercised any options at these prices points to only one thing. The only way is up!

Thanks Steady for your comments. i was referring to there being no influenza vaccination for the population in 1918. As we were discussing whether a similar situation re mortality in young people could emerge with new Covid Variants I was pointing out that we would need to consider the impact that the current the vaccinations are having. ie we could not compare like with like.

Zylo- noticed today’s trading was 181% above average. So the 9.1% fall was not down to low volume. Something is definitely brewing imho.

Sorry 1918

Thoth another fascinating scientific article that postulates the cause of the high mortality of young people as immunity response over reaction. There were no vaccines available in 1818 so we have to factor in their effectiveness now. But it is clear that therapies that can calm over reaction of the immune system such as Sd1801 are going to have a massive part to play in the future.

If someone in the press starts probing this- could be trouble ahead.

Working/ Krone, apologies if I am talking rubbish but Sierra has around 85% of shares owned by institutions. There is only a relatively small float so the share price fluctuates widely on sometimes very little trading. As such, news such as a SRA737 combo could send the share price to $100+ Very quickly. I am wondering if this share price drop is the sign that something is about to happen. The company seems to have a close relationship with institutions some of which are big hedge funds. Is this a plan to get them another chance of buying shares at a low price prior to the news announcement?

Coz - the Sanofi pill for Covid by Christmas is a vaccine. Sareum’s therapeutic pill stops the immune system over reacting. Two totally different approaches.

I could live with that( with gritted teeth) but it has to be at least over a £1.00!

I wouldn’t argue with that Philboro but there is increasing evidence of small up and coming companies deciding to go along with a partnership approach. I am starting to think that would be the best way to go in terms of value for shareholders.

Should have included SDC1802,as well. Make it tens of pounds.

Zylo - I am not concerned about the current price or near future. But if you are a pharma out there looking for next generation inhibitors and reading the latest scientific findings on TYK2 and all the ailments it can potentially cure or alleviate I would be doing everything possible to acquire SDC 1801 - and be paying an awful lot of money for it- starting in pounds Sterling.

Yes. We should have every confidence in Tim and John to make the decision that is in the best interests of the company and Shareholders.

Hi Bluedreamer - there have been quite a number of covid trials and not many if any have been taken through by government support. All trials have been short as befits the need to act fast during a pandemic.. Sareum’s trial will be the same duration as most other trials whether undertaken by private companies or with Government.support.