Member Info for Aldebaran

Hi JHFH. Thanks for that.

No I've not decided to buy I'm just going over all notes and trying to learn a bit more in readiness for a future potential buy. I'd be happy to buy much higher with more certainty and with some good support underneath it i.e. 200dma

Your right I did flip on avacta I'm always sceptical at first. It pays to be but now I'm convinced of the full investment case there and of course it's now good good volume under it and the 200dma so it offers some level of protection. Lord knows us private investors need it. We need all the help we can get!

Have a great weekend too. Chow

*Haywain that was supposed to say. No "ha".

Im curious could

Thanks Ha

You don't think i know it targets FLT3?

My question is whether this target depletes over time i.e. does it mutate to evade treatment and become resistant or does it deplete due to attack by the modified T cells

That's a really long way to write "I don't know Alde"

Your minds therefore are made up on incomplete information, hence why your now heavily underwater and have an absolute torrent of placing shares and warrants above here to try and bust through before getting anywhere near your breakeven point.

Not wanting to know why the SP is around alltime low is bizzare for a supposed investor.

I think there is a LOT you and others haven't thought about and this has become a fan bored not a discussion bored. An echo chamber if you will.

Not brilliant for trying to learn and make sound INVESTMENT decisions is it.

Anyway, you don't know whether your treatment becomes less effective over time. Embarrassing given the duration you've been here ramping it

Pingu, you don't know the answer do you and are now questioning it yourself hence your lazy response to once again just come at me.

Am I not allowed to ask genuine questions?

I think given the SP is around all time lows then maybe we should try to understand why. Everyone saying the science is sound and it seems it to be fair but its worth exploring anything you haven't thought about such as target depletion, is this or is this not a problem? I don't know hence why I'm asking. Investors here should want to know.

Also, what about drug costs and whether they will be prohibitive for the masses or not?

You want to scream things like go hemo go and slate other more cautious posters like me personally rather than debate the points raised.

Im concerned about the number of warrants being issued aren't you guys and what can be done to stop it. Where is the commercial plan and nouce from vlad. Ok he's made some changes but much more needed.

The reason most are under water here is because you haven't full explored the investment case in my view. Lot of you got excited by promising science and now your upset when more experienced cautious investors like me ask questions and want to make comparisons against other companies on a similar journey. Seems strange to me. This is meant to be a discussion bored not a fan page

Avacta investors been where yall are and have suffered the pain and learnt a lot in the process. Most would do well to learn there story to see the potential pitfalls that may come here. Years ago we were where you are now all excited expecting FDA approval to be thrown at us and big pharma to be chomping at the bit to buy us. Didn't happen though and now with hindsight its obvious to see why. The lessons learnt there would be invaluable to some if not all of you here as HEMO is a few years behind IMHO

JHFH no avacta is not a threat to HEMO.

They are targeting FAP whereas hemo are modifying T cells to express a chimeric antigen receptor. What id like to know if if the target depletes over time making treatment less effective. Do you or anyone know?

With avacta tech using the bystander effect then the target doesn't reduce overtime so treatment starts effective and remains effective throughout. Again avacta not a competitors for hemo but the comparison of them both is useful.

Was showing huge promise in vitro. They did this because the opportunity of there other drugs eclipsed this which is a good thing for HEMO.

Now back to CAR-T , what is the MOA do you know? And do you suffer with target depletion? And the treatment becoming less effective over time?

Hi JHFH. My sleep pattern all over the place due to shift work which sucks unfortunately.

Avacta did recently shelve their blood cancer drug AVA3996 which was an analogue of velcade (bortezomib) even though it

Price failed at the 50dma yesterday so technically looking like it just doesn't have the momentum to push onwards. If spicy tuna is right about the sales figures then it makes a fall to around 25p look more likely than not IMO

*you get all the cancer killings power with zero side affects. Its like chalk and cheese to existing chemo.

Silent in the bloodstream.

Active in the tumour.

Also know as the holy grail in cancer treatment. DYOR

Ive already said the RNS was good and also that the share price is likely to rise at least short term. Good volume and a nice green candle.

The RNS could have been better though,why not providing more detail about the 2 patience other than their alive which is great but are they hanging on by a thread ? Has the cancer reduced or at least not got worse? What have the side affects been like? So again good RNS but could and should be much better. Loyal passionate investors like you guys deserve it. Even if you are zealots.

Now, where is this idea about funding being provided at 180p coming from? Why not 200 or 150? A group of you have decided 180p is what it is worth??

Also, why throwing warrants around like confetti? Yall should get out that habit and as HEMO progresses hopefully you won't need this extra incentive to invest as just being able to buy without spiking the share price should be a blessing. So when will the confetti stop?

All that will happen is people will cell there shares once broke even or 10% up on them and keep the risk free warrants so the share price never goes anywhere which isnt fair.

Someone asked how hard is it to raise 5m? Come on, its nothing. Avacta new bored member Richard Hughes laughed when he was asked how avacta can find 3m every quarter and said its nothing and that he'll sort it and he has within a couple of weeks. There is money out there and 5m is nothing.

And nothing wrong with chemotherapy, it is proven therapy and really does kill tumours. The problem with it is that current delivery methods basically bathe all cells of the body in it including the tumours which is why is produces ghastly intolerable side effects.

Avactas precision technology delivers the toxic chemo just to the tumour so you can all the

And also why are warrants being thrown around like confetti and offered even to random bulletin bored punters?

Come on guys let's start to be real here please. If hemo is so great people should be falling over themselves to invest even at a premium yet seemingly not, or certainly not without some nice warrants as a backstop. Again more warrants = more shares in issue ultimately which restricts the upside potential. Say what you like about avacta but there raises have not had to be done on the back of warrants and last one at only 7% discount

Just catching up now seems to me like a positive RNS which has delivered good volume here and a nice green candle likely news will be digested over the weekend and price will continue to rise for at least a short while.

Where is all this 180p placing deal stuff coming from? Are you saying that's what investors think the company is worth?

250k per month is smaller than 400 but still not insignificant when company running on fumes. Why doesn't Vlad just raise £5m and be done with it? It will be bad for existing holders short term but would then allow the SP to move more freely.

Also, 3 patience dosed is great and 2 showing promise but there is such a long road ahead you guys have no idea. Or it seems like you don't. Anything can go wrong with these trials. I'll give you a example, yes related to avacta but during the dose escalation study one patient suffered a serious cardiac event that put the trial on hold. Turned out 6 - 12 months later this event was unrelated to the drug and more to do with existing condition of patient but still caused a shortwave in the share price and huge delay and financial problems.

Dosing 2 patience sorry 3 here is nothing long long road ahead full of potholes. Expecting price to rise short-term but ultimately pullback as this remains a good science experiment but not a investment. Unlike avacta which is miles ahead

Don't get too excited, with all those warrants and placees just above here it will put a natural cap on any rise.

Remember folks, investing is about more than just liking the science. Ok now I am off to bed.

Hemo is trading at all time lows.

They've dosed 3 patience in a phase 1 safety study

2 have gone well so far but we have no idea how 3rd will go, perhaps a DLT will appear? Perhaps there will be a sudden but unexplained medical issue that holds the trial up, a hole myriad of things could go wrong and there is a looooooong way to go here. Lot of hoops to jump through.

I wouldn't get too excited about this news. Wake me up when the stock is above the 200dma .

Right bed time zzzzzz

Hey I dont wanna argue either. If Vlad is being offered money at a premium then for crying out loud what's up with him, why doesn't he take it? It would turn the SP around and alleviate fears of a discounted placing or the company going private. I think it would be a great thing.

You know what I did learn recently, avacta large shareholders also offered avacta ex ceo Alistair Smith money at a premium at over £1 per share a year or so ago and he inexplicably declined. The SP then went on a spiral down to its 27.5p low. It was a crazy decision in hindsight. Vlad needs to take same care of the share price as he is doing the trial. This is a PLC not his private science experiment. If he had an ounce of commercial acumen he'd take the money and return sentiment here. Im all for it.

Im not against HEMO either and would like to see it turnaround just right now there's no sign of it happening and if their is an easy option to take some premium funding then hell why isnt vlad taking it?? Does he want it to go private perhaps? How close to him are you? Interesting.

Anyway, I'm on nights tonight and need to head off to work. Peace

This isnt the same hemo, fine. Great. Doesn't still make.it inventive for newbies.

Your comparing it to what it was as opposed to the plethora of other opportunities out there. Largely I suspect because a lot of you have tunnel vision and are anchored to the price you paid. It looks cheap because of where its been but anyone new looking in fresh won't see it that way. They'll see cash running out and more dilution inbound with nothing commercial to support the company as a backstop and a chart in total disarray.

Seriously now, how long until the next dilution event and if you and others are willing to invest at a premium just do it already and end the rot. Good on you I say