Member Info for 13thmonkey

28th June 2.0

So a whole 12 working days ago it was 25% higher than now.

Nice cherry picking of numbers though.

Most that 34% was last week due to the fire. please try and think, I know it's hard.

Also note on the slides the range of dox in the tumor, it varies quite a bit, amongst humans, so extrapolating from mice is impossible as the human to human variation is high.

You need to understand what mtd is, simply max safe dose, the upper edge of the envelope of dosing regimes. You're talking about something more like a biologically effective dose which is the fall back position.

Note that on one of the slides it was noted how much was needed for 4 different mechanisms. So there are 4 effective dose levels they'd need to hit, the highest of which was met in de4 I think. But without knowing the mtd you are not going to know how high you can go, and it's quite possible that it becomes more effective at higher doses, doses that have been unachievable with std dox as its too unsafe.

No dimwit they would not have an accurate view of what the mtd is, there are too many factors. The mouse trial would let you know if it was likely to work that's all. You are embarrassing yourself, for the nth time, n is getting quite large now.

Duplicitous? If you think that management are being duplicitous then why are you even invested?

Strongly suggest that you learn the definition of that word, or perhaps you just carry on and see how the endgame plays out for that kind of accusation, actually.

touk full of **** as usual, just sell and move on if you're not happy.

there is no way that the mouse model would enable the estimates for the number of cycles before mtd or even the level of the mtd.

Yes, but they need to know how much more they can use. Are you not paying attention in the back? If you don't like how they are going about it then sell and f off.

It can't use valcade, there's no hook for the linker from what I understand

Will it, or will it just cause more PI's wanting 10% gains to turn up?

Other than all the people here that wrote about it?

And you know what, I wouldn't have minded if they had said that it was being shelved for a while.

There was some interesting accounting for sales that resulted in a halved figure when it unravelled. They owe suppliers.

I wonder if they've been hit by deepverge and microsaic's troubles. The taint might go wider than current, they were a favourite of his.

Dox is proven, this is delivery.

More if you imagine a pipe feeding the blender and then recirculating so that they go round and round, like a circulation system. The blender isn't that efficient only blending 20% of what passes through it, there's a little pipe that slowly takes some of the mixture away and excretes it. As it circulates round and around more and more gets blended.

Note that this is a wholly made up percentage.

Theb point is that it doesn't visit the tumor once and never goes back it visits it again and again for hours and hours.

And the classic conspiracy activity of a dump of information big enough so that no one can read through it all in a reasonable amount of time. Colours have been shown and nailed to the mast, tw at it is.

We're at the level of a conspiracy theorist now with 'do your own research' and then stating it's not the right research.

You wrote 88 tweets, and flew to London where we were told nothing that wasn't in previous reports other than it's still going well, and now you've sold. I question your ability to research. There's lots of room in the market.

Ok I'll bite. Are they wholly new drugs? If so then they'll need a much longer test than just a new delivery mechanism. That's for starters. I'll have a look but that'll plus minimising the possibility of significant side effects by releasing only at the tumour site will be most of the answer I'd need.

TL one of the slides indicates what therapeutic levels are for 4 different modes of treatment, that same slide identified the amount found in tumours slide 26. So no we are not talking about minimum levels.