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WOW Celtic, did you go to school? You need to work on your grammar and language fella.
Sflf.
Pragmatic summation but be prepared for some heckling from the "owners" of this BB
Good morning HBD,
An excellent post, I recall the discussions here way back regarding Christian Hassiq and indeed Triparna Sen being named on an SRA737 patent, and the move to Boundless Bio for Hassig; it certainly piqued some interest at the time.
As you can probably imagine, I have several pages bookmarked regarding Hassig, his patents and movements as he is IMO the most obvious potential suitor to take SRA737 forwards having seen the potential whilst at Sierra Oncology.
These things take time, but its certainly interesting to dig and delve, looking for snippets and leads. One must keep the mind sharp and trained as much as the body - (I much prefer this to crosswords & sudoku's so its a win!)
As a side note, and as you are clearly aware, looking at patents can really provide an insight into the science and potential direction for companies - doing so has provided very good early "ins" when investing in the past - sew up the intellectual property and protect the potential assets early and a company is already doing more than many of their competitors. Something I feel Sareum has been very good at! "News flow" & creating a buzz, not so much!
Thanks again for your excellent posts
ATVB
So the small lift from the 737 was was short lived . That gain has reversed and we're basically back to the same low levels. It seems there's no appetite for the stock on the open market with private investors. And no institutional investors were interested in the stock either as a placing was taken off the table in favour of the deal that was done.
This will now take very significant news, with a clear path to monetize the assets, to move the share price north. Here's praying that news comes soon.
Strap in, I think it's going to be a bumpy ride.
Time will tell. Hope it comes good. Bye all
You are right Lazarus .. it hasn’t been all bad here although the current downward trend is baffling given recent news and progress on 1801 .. it makes no sense at all. The rise in 2021 gave all LTH the chance to do a bit of top slicing; the gain I was lucky enough to nail down when I sold 1/3 in the summer of 2021 means even if SAR drops to 20p I will have still doubled my initial investment made in 2011; however I want to see it where it belongs which is up over £2.50 and beyond not least because there are people here who first invested in 2021.
Thanks for your best wishes cfh.
Surfie - A Freudian slip surely - you instead of we?
Sienna - It hasn’t all been down in the doldrums - Sareum has had a few good periods where we have all made good money.
Believe the science and follow the news. Otherwise why would you be here
Https://medcitynews.com/2024/01/gsk-cancer-jpm-targeted-oncology-drugs/
Vented a similar post possibly a couple of years ago.This company has got sweet FA.Poster presentations and conferences.Lambasted at the time,when the sp was much higher.Good luck remainers,you're gonna need it.From a former pharmaceutical research chemist.
OMG... you couldn't make it up over 75p down to 57p so far this year. An 8% drop today and still the faithful bang the "believe in the science" drum. Even Afham has buggered off! I'm invested, or at least what I have left is still invested but this company is a joke.
A nice range of investors, Boundless Bios have.
Ridiculous post by you Siennaj, was it tarot cards or a crystal ball. Blimey.
Siennaj, disagree with some of your post. Just look whats happening here, i agree timelines get consistently broken but nothing wrong with the science to date, thats more relevant than dates
I wonder of Afham has become disillusioned with the extremely long wait here for anything to happen. I'm not a lth but I understand a good number here have been here for between 10 and 15 years and to see the price nearing 50p which is 1p before the consolidation must.be very disheartening. I've held Sar for about 3 years now. I've sold out as the price keeps dropping and trying elsewhere. Essentially sar haven't sold anything and what was supposed to b products that the big boys would b scrapping over appears not to b happening. I only hold 2000 shares now but to see this continue to decline us sad and I'm glad I was never involved over a decade ago. Such a waste of time money and hope sad to say
Ahfam, hopefully he’s received a short term ban. Yes he was a feisty character, but he was only protecting his investment against the crap that was posted. If he’s banned, they should re in state him.
It's easy to think you're seeing strong connections between things when the reality is it's just a coincidence so I hope none of you spend too much time exploring what follows (unless you're Citizen!)
Open the link to the US public patent search site - https://ppubs.uspto.gov/pubwebapp/static/pages/ppubsbasic.html
In the Basic Search box just search 'everything' for SRA737 and you should get 113 records (the latest of which was published on the 4th Jan 2024).
Now the fun begins. Looking down the list of inventor names I thought I recognised the name Christian Hassig. I entered the corresponding patent number (US-20230272485-A1) into the Google Patents search engine and got this result -
https://patents.google.com/patent/US20230272485A1/en?oq=US-20230272485-A1
SRA737 gets a mention 13 times throughout the paper - hardly a big deal as it gets a mention in each of the other 112 papers in the original search. Anyway, the patent is allocated to some outfit called Boundless Bio Inc where Hassig now works. That would be the same Hassig who worked for Sierra Oncology as Chief Scientific Officer. It's a small world.
https://www.biospace.com/article/releases/boundless-bio-appoints-christian-hassig-ph-d-as-chief-scientific-officer/
And did I mention Boundless Bio appear to be a private company? Scroll down to the 'Investors' part of the page https://boundlessbio.com/who-we-are
Anyway if Boundless Bio turn out to be the new licensee owners of 737 I win the internet for a day though as I said, it's easy to see connections that aren't really there!
That happens regular with companies, doesn’t mean it’s a short that you’ve gone towards
Hmm. Unknown trades may be due to RF going short?
Last post 30th November and no hint of a problem; agree hope he is okay!
Even if not Numedi. This is the type of company I think 737 has gone to. Quick turnaround. Quick Google, Pulmonary Fibrosis market size expected to be 11 billion by 2031.
Or he got tired of getting it wrong, litterally all of the time. I liked his posts until he was trying to discredit posters that were giving opinions that turned out to be true. He could have sold up for all we know. I always thought his expectations on timelines were way off actual reality. I hope he comes back, even if it to reignite the board a bit.
Happy new year one and all !!
Something or nothing, but as HBD mentioned, newly published Patents are a great area in which to dig for info.
Could our CHK1i have be taken on by Numedii Inc… https://numedii.com/
"About NuMedii, Inc.
NuMedii, Inc., discovers effective new drugs by translating its predictive data intelligence technology into therapies with a higher probability of therapeutic success. The Company's exclusive Big Data technology, originally developed at Stanford University, utilizes large amounts of scientific data together with proprietary biological network-based algorithms to discover drug-disease connections and biomarkers that are predictive of efficacy. NuMedii translates these predictions into novel de-risked drug candidates and partners with pharmaceutical companies for development and commercialization. Headquartered in Palo Alto, California, NuMedii's investors include Claremont Creek Ventures and Lightspeed Venture Partners."
Patent flagged up as follows:
“Method for treating idiopathic pulmonary fibrosis
Abstract
Provided is a method of treating idiopathic pulmonary fibrosis (IPF) using an agent that reduces or eliminates the kinase activity of checkpoint kinase 1 (Chk1).”
https://patents.google.com/patent/WO2020154608A1/
full .pdf: https://patentimages.storage.googleapis.com/1a/77/26/ef2bab65850e7b/WO2020154608A1.pdf
As ever, every CHK1i under-the-sun is to be mentioned….
But delving into the document its clear extensive testing has been carried out using various CHK1i molecules.
SAR020106, CCT244747, CCT245737 all mentioned, but just how many other molecules are/were available for partnering…?
Food for thought and as tenuous & flimsy as you like, but good fun for the old grey matter whilst we await SDC1801 news.
On social media/their own website etc. Numedii haven’t been that active, but clearly they saw value in CHK1i as applying for patents isn’t a cheap endeavour!
They also have a history of repurposing later-stage assets, and passing them on to a bigger fish....
ATB
He has probably been banned.
He must have had numerous posts reported by the team of antis that regularly appear and unfortunately . that probably has done the trick
Yes, the board has been very quiet without him. Hope all is good in the Ahfam world but, the name calling was always started by him.
I hope he is ok too. He was on the end of some personal abuse recently as well as giving some out himself. He was correct about the sp disconnect which is still evident.