Roundtable Discussion; The Future of Mineral Sands. Watch the video here.
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Na mate, it was the same 20 years ago when I pinned mice to a board to do tests. (in a lab) basic research models, shame I didn't continue, do com gas and air con now tho.
That’s Hemogenyx
RK,
these mice are genetically engineered, and humanly dispatched. Very close to human models without using human subjects. See link just for confirmation on use of mice modelling https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533445/
RK, Your comments on the revolution this would create in treatment are well made. Many would benefit. The animal study viewed in the cold would suggest efficacy transfer to man is highly likely. Am sure many in the are will be viewing next stage with interest, and there will be several supporters in train.
Best Regards
Keeping focus on the Pre|CISION Affimer technology, the strength of the attraction of the Affimer loaded with a high concentration of the chemotherapy conjugate directly to the cancer cells / tumour as tested in initial tests has shown that the mice that had the tumours all survived. This in humans would be a huge step forward.
I mentioned earlier the opportunity for diagnostic testing uses my Affimers to find specific cancer cells. This kind of revolution in detecting and killing the cells, without multiple scans, radiotherapy, multiple blood tests and the weeks it takes even with the highest priority patients would increase survival and quality of life.
The change in a very fit person after one session of chemotherapy is incredible, within 12 hours they go from almost super fit to so tired they need to sleep for 12 to 18 hours a day. Note not all chemotherapy has the same side effects. But the reduction on ability and the effect on people’s ability to cope. Let alone the massive risk of infection meaning many patents have multiple stays in specialist oncology wards during chemotherapy is so intense for patients and careers.
These are all such positive opportunities for the pre|CISION therapeutics.
Keep safe all and have a good evening.
Cheers Rich
Nothing wrong with a bit of ramping!! I completely agree with you though as per my earlier post
@Kong1
It does rather seem like ramping, I'm afraid.
(but my fingers are crossed, too)
13M thanks.
Simple and sweet
Hope this dosent seem like ramping,
But if Avacta have something unique with the Affimers, and it passes all clinical trials and proves to be successful, not only will they be the only company in the world with this technology, But every country in the world will want their products on their shelves.
Avacta will have total dominance for a number of years before other companies create their own. The financial value to Avacta would be unthinkable.
Now regarding this coronavirus,
again if Avacta pull this off and get it approved, and it works, the world financially is their oyster. The share price will just explode.
I`m also hoping that the technology may be used for other viruses across the world, so again, it may have other uses after Corvid 19 abates.
Now who ever can ride this share to the limit and hold, dividends may play a huge part in years to come.
many outcomes for any who has the stomach.
we just want the technology to work and be passed.
Good luck to all
Travel light, my understanding is that you make an affimer that locks onto a protein that are very common in cancers and less common elsewhere, at the other end of the affimer is a drug trust you want to deliver to the tumour.
RK best wishes to you and yours
Thanks. Wish I’d worked this hard in school.
The pre-cision tech is understandable. Wish I knew more about how affimers can be used to treat cancer. Looks like multiple ways not just exposing tumours to immune system.
Top man RK as always top post, agree this company has so much to offer.
TL slide 15 as well on pl75 link.
PL75 that's a great presentation not seen that before, thanks for the link!
And I thought the placing was just a money making scam ;)
Avacta has a big future very glad to be invested for the long term.
Hi Wylie,
Last year my wife went through full treatment for oesophageal cancer and this resulted in her having her oesophagus removed. The follow up was additional chemotherapy and radiotherapy. The recovery is very slow and the long term side effects are very difficult. Living with nausea everyday. They make a new oesophagus from the tummy so your tummy size is reduced. She has very low energy, and her life is very restricted. She has had throat stretches, tummy stretches and she gets amazing care from the NHS and her support team. Early diagnosis and targeted treatment may have meant reduced surgery. But she had the big one, an 11 hour operation.
Trust me we both see the benefits in this treatment and if Avacta can succeed it will be huge step forward in chemotherapy and save many more lives.
Chemotherapy effects the immune system to a critically low level, takes away the sense of taste, hair loss as well as many other horrendous side effects. This is why so many give up the fight.
My passion of this company to succeed is way more than from a financial gain.
If I am positive and seen as a cheer leader for Avacta, I think people will have more understanding of my position and that of my good lady.
I am sorry for your loss and I wish you all the very best. Thanks for your kind words.
Cheers Rich
Tl my understanding, which if corrected will change, but the immunotherapy identifies the cells to the immune system. But the pre Cision releases in tumour cells.
It finally dribbled thru, thanks all! Slide 6!
I’ll just keep spamming links, one of them might be useful.. slide 6 is a one page summary.
https://avacta.com/wp-content/uploads/2020/06/Placing-Presentation-June-2020-1.pdf
WEC I hope avacta bring a lot of things to market so more friends and family are not lost. It’s nice to be invested in such a company
I tried to summarize RK post.
Affimer today is not used to treat cancer. But the possibility to do so would be by blocking the ability of tumour cells to hide. I don’t know if any therapy has been announced for testing.
Pre-cision is coming online soon in test phase. It allows drugs to bedelivered directly into tumour cells.
That’s two different things, but earlier in the thread it seemed they were being linked. I thought to provide my understanding. RK posted a informative post with lots of long technical terms. I thought a shorter summary might be useful:-)
Cheers
TL, have a gander....
https://avacta.com/therapeutics/precision/
No one better than the man himself to explain...
https://avacta.com/alastair-smith-provides-overview-of-precision-prodrug-technology-and-update-on-ava6000-clinical-trial/
Thanks for posting the details RichKen. Like you, whilst the Covid19 aspect is a good short term play I view the potential cancer applications as Avactas most exciting technology. Unfortunately one of my closest friends succumbed to Oesophageal cancer about 5 years ago - he was only 46. More recently I lost my mum, although in her 80s, to Endometrial cancer. So products that will help target existing treatments in a more focused way must be good news. There are many cancers out there that have had little research and are devilishly difficult to treat - Oesophageal being an example. I have a small position here at the moment but intend to increase it due to the important and exciting technology they are developing which I hope in years to come might render some cancers as something we can live with if not eradicate.
Not sure what you are paraphrasing there?
The approach is to deliver the required treatment directly to the tumour.
Am I misunderstanding your understanding?
All the best.
RK
If I can paraphrase
Pre-cision targeted drug therapy
Affimer treatment, blocking protein and allowing tumour to be dealt with by bodies immune system?
Atb
The targets for future Affimer pre|CISION
Avacta has so much potential in this particular area.
The first is AVA6000 Pro-doxorubicin, Doxorubicin has been a standard of care treatment for advanced soft tissue sarcoma (ASTS) for 40 years. Treatment is currently limited to six cycles due to cumulative cardio-toxicity. However, the global market for this generic drug is still $1bn. AVA6000 Market Opportunity for three opportunities ASTS, breast and ovarian cancer, with peak sales for a safer and more efficacious form of dox in the US/EU alone is estimated to be $1.5bn pa with a 5-10% royalty to Avacta plus development milestones in the near term. This is an incredible prospect!
But then the opportunities to use the recent funds to develop the additional pipeline of pre|CISION pro-drugs, some of which have already been synthesized, with an addressable market of many $billions per year.
Including these drugs but not limited to:
• preCISION Velcade
• preCISION Paclitaxel
• preCISION Oxaliplatin
• preCISION Gemcitabine
• preCISION Capecitabine
• preCISION PARP inhibitor
• preCISION PD-1 Inhibitor
• preCISION AKT inhibitor
• preCISION Balixafortide
The combination of Avacta’s two proprietary platforms to deliver chemotherapy and immunotherapy in a single drug molecule has two key points:
The "warhead"
Released in the tumour by the preCISION linker chemistry.
• Selected to kill tumour cells and create an inflammatory event that recruits the immune system.
• Potential for a pipeline of TMACs using different immuno-active warheads
Then the Affimer Immunotherapy:
• Supports the immune attack on the tumour by blocking the signal the tumour uses to evade the immune system.
• Potential of a pipeline of immunotherapy and targeting Affimers including bispecifics
If the trials are successful with AVA6000 the developments in these other treatments will surely be accelerated. Within 2 to 3 years we could see the results of these developments being used in Oncology clinics around world saving lives.
This area has massive potential!
Cheers Rich