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Will bind....please admin an edit function !!!!
Hi
My understanding is affirmer a protein with two sites of 9 amino acids that can vary. Variation allows lots of combinations some of which will. Ind with different proteins.
Pre-vision is a substate that locks in a drug. Tumour cells produce an enzyme which attack and breaks this substrate and drug is released.
From
Avacta web site.
Avacta’s proprietary pre|CISION™ technology incorporates a substrate that is sensitive to cleavage by fibroblast activation protein (FAPa) which is highly upregulated in the tumour microenvironment of most solid tumours compared with healthy tissues
But yeah on the web site it also says they want to do some thing similar with affimers. That’s what I mean with fluffy at least for me as a layman.
This presentation will help understand the pre|CISION chemotherapy treatment in the first trial coming later this year.
https://avacta.com/alastair-smith-provides-overview-of-precision-prodrug-technology-and-update-on-ava6000-clinical-trial/
I hope this helps many trying to see where this is going.
Cheers Rich
Travel light. I think the pre Cision is an affirmer that coats an existing proven chemotherapy. The affirmer targets the cancer cell binds to it and releases the chemotherapy into that cell. Not the surrounding tissue. Therefore reducing side effects, and being alot more focused and targeted. If works it can be used for other cancers and chemotherapies. So you don't have to use as much chemo, lessen the side effects.
I think that is the point of the technology. It releases the drug into the tumour.
All The best.
EGTP two different mechanisms involved with the affirmers for c19, and the affirmers for Pre Cision.
Affirmers for virus, bind to the virus and spike protein, which stops it entering the human cell. The virus replicates in the human cell which them causes the cell to rupture and release all the replicated virus.
The precision binds to the cancer cell to release the chemo into the cancer cell not the surrounding tissue. So I agree but thought I would highlight the different mechanisms.
Hi
I think the company is a little flaky sometimes how it describes its tech.
They do say they want to be able to do targeted cancer treatment with affimers but what they are pushing for that at the mo is a second tech Pre-cesion. It activates and releases a compound when in a tumor cell. They license the patent.
Happy to be corrected if I have wrong end of stick.
I think if avct can use affirmers for there precision chemotherapy, and develope affirmers for virus zeka and c19.
Developing an affirmer for a bacterial cell infection( considering they have developed an affirmer for a cancer cell) wouldn't be a massive leap to make. If the company decided to fund that research arm then that would be a major breakthrough in the fight against antibiotic resistance. And the hospital superbugs. IF THAT IS THE WAY THE COMPANY GOES.
No worries mate,
I do try and read all the posts but today having read another board with endless argument I only skimmed over the recent ones here.
Agreed egtp if these two covid tests get approval and go to market it will be a momentous achievement for avacta and proof that the affirmer tech can be applied in the real world.
The "astronomical " income that can come from that alone will propel avacta into the big time. But it also opens the door for an affirmer revolution and massive interest from large pharmaceutical companies wanting a piece of the pie.
Exciting times ahead...
Sorry PA100
Read your post wrong so in total agreement with you
Antibodies are completely different to Antibiotics.lAntibiotics work vs Bacteria
Absolutely correct Pigster
Antibodies are proteins, produced by cells, rather than being cells themselves.
Antibotics and antibodies are two very different things. Antibiotics specifically target bacteria and are non living themselves, antibodies are cells that the human body first learns to generate and target viruses and bacteria, and then it generates more on demand once the target is present. Vaccines just give the immune system the chance to learn on something that looks like the virus.
A bold statement indeed – so for those here only for up coming world beating covid-19 tests and cure, I would recommend to also look at
https://en.m.wikipedia.org/wiki/Affimer
Alexander Fleming re-wrote science by pioneering a proactive way to fight most bodily illness by in effect injecting an invasion force (antibody) into the invaded body to assist the body in wagering war on the invader until victory, it was brilliant, a world beater and so-named Penicillin, and antibiotics / antibodies have been the standard way since 1923. Of course the only problem / side effect has always been the bodily energy, strength and damage used fighting and winning this war.
What Avacta have done is reinvent Medical science, their tailor make affimer molecules enter the body and instead of assisting it in waging a war against example the covid spike, cancer, Leukaemia, or example any future virus, they simply impersonate then enter the covid, or cancer cell / spore then neutralise it. In effect Affimer molecules are an injected peace keeping force / high level negotiator entering the body to simply neutralise the war, the end product neither side wins - but great thing is the body, or grounds possessed quickly emerge without battle damage - now that to me and many others is magic !
This is the reason Avacta have JV’s with US majors like Cytiva (formerly GE) and Adeptrix and most importantly they have patented the Affimers and have the Licences - this isn’t pie in the sky jam tomorrow stuff.
In the short term the tests will generate massive income and orders hence the reason Some of the Boo Hoo boys have set up medusa19.com to make a fortune selling it on.
This world changing science has been 6 years in the making – if it’s just the covid-19 tests and cures that once completed with billions of confirmed worldwide orders spiking the SP to £5 maybe even £10 in the next few months fine - it’s a great trade and I’m 90% a trader too.
But for the majority the focus is way beyond the current £100 billion Cancer Leukaemia market
DYOR and best wishes