Member Info for WedME

Part 1

All link to evidence on last part.

In the midst of the uncertainty that derampers and rampers alike cause it is easy to be confused.

A confusion that breeds fear, misunderstanding, and doubt.

In times like these there is only one way to see clearly and that is having a strong view of the fundamentals. Knowledge controls fear. So take control to drown out the noise.

SNG001:

We know this product works. The science proves it. We know why and how it works.

If anyone is unclear on this I suggest they look at some of the posts - most notably from pmjh - or my explanation from Tuesday. Interferon beta-1a is the best and strongest antiviral we know of. It is your body's greatest weapon against viral threat. And the fact that Synairgen have created a nebulised version without serious adverse effects is simply mind-blowing. Because of nebulised interferon beta-1a's ability to kill any virus, SNG001 can - and will - be used not only against this virus but also against every one in the future. And there are several on the way.

Unlike the other therapeutics being developed that mimic the virus with use of antibodies, which will give you the same over-activation response in your immune system that causes 'long covid', SNG001 targets the virus directly by stopping it's ability to replicate and then aids in the recovery of your organs. It treats cause, symptoms, and then aids recovery. There is not a single other product that can do that.

Not to mention that the immunity effects from antibody therapy is short lived meaning you can then catch the virus again in a worse state than you were the first time.

I think it's been a rather good week on this board so far with some great input and media exposure of both Synairgen, Stephen Holgate, and the drastic increase in use of interferon beta-1a around the globe for COVID-19. Lots of positive things on the way for this company. And this week is certainly looking like it can hold some very exciting developments.

Things continue to decline worldwide with this pandemic, sadly, which include record high infections, hospitalizations, and worst of all deaths. There is no doubt things will continue to decline going into colder weather which makes me glad that this product is currently being marketed as it is sorely needed. It is surely a bright note in this dark pandemic.

Let's have a great day and week ahead with the positive updates rolling on in.

It is definitely interesting, JoeyD. I think it shows the world of interferons is about to blow up. This pandemic has really highlighted their use. Certainly glad Synairgen got all their patents in place before it does.

"Alpha interferons". Funny we just touched on the negative effects they bring. Plus they are quite a bit behind. It is interesting though that it is yet more evidence that people are focusing on interferons. Good find, SGD27. Just more proof we are backing the right horse so to say.

That's why your research has been simply outstanding, pmjh. I am very grateful for it. I have been looking for negatives as well both from a personal and investment view. So far it's been a awful lot of positives. And that makes me even more sure about this. I'm a very critical person when I research and this is the first time I have struggled to find any negatives.

@Sparke1. I'm sorry to hear about your son. All my best to his recovery. Kidney transplant is something I am very aware of from my own life. When dealing with interferons and organ transplants it comes down to which interferon is used. Interferon Alpha has directly been linked to transplant failure, however, during the Covid-19 pandemic IV interferon beta-1a has been used with organ transplant patients successfully.

Here is a case:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228209/

I can also add from my life that I have received IV interferon beta-1a without kidney rejection issues.

When dealing with interferons most of the data is from the IV form which carries with it adverse effects of it's own. That's what first got me interested in a nebulised version. That also makes it difficult to say in which cases it shouldn't be given. More studies need to be looked into that topic but from what I see it is something that I am personally very excited about regardless of the SP or my investment.

As far as interferons go, interferon beta-1a is the safest of the interferons when it comes to comorbidity. Elderly people have a natural suppression of interferon beta-1a and are in desperate need for it if they contract the virus regardless of risks involved with other illness' they may have. I would say that the risk is certainly lowered with a nebulised version rather than IV.

We are dealing with an entirely new version of the drug and that is why the home trial data and peer review will be very interesting to read.

So far all the data is looking rather good from my end. It is certainly much easier to find positive information regarding this drug which is in itself quite telling.

@Sparke1. I conferred with several Profs I work with as well while writing this. Very glad to have gotten their input.

I see the article you posted. I think nebulisers use is still safe in a hospital setting. The use of nebulisers has gone up during the pandemic in fact I read the other day.

This is a great interview with Prof. Dr Kamin, Medical Director of the Hamm Lutheran Hospital I read a few days ago where he goes over the use of nebulisers during the corona pandemic.

https://www.pari.com/int/blog/treatment-and-nebuliser-therapy-for-covid-19-in-hospital-interview-with-the-prof-dr-kamin-medical-director-of-the-hamm-lutheran-hospital/

And there are procedures in place for nebuliser use in a Covid-19 setting:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172670/

The evidence against the use of nebulisers is not proven. It is simply a concern some medical professionals have.

If the best treatment involves nebulisers then it will be always accommodated. And currently is. I see it every day in hospital settings . And it clearly worked to do in a hospital setting during the SNG001 trials. It can be used in a home setting as well so it I don't think the situation warrants any concern.

It will be very interesting to see the home trial results when they are available.

As far as cons go my only concern was how quickly the drug could be marketed. That all changed with Numis and Clinigen along with the updated patents. The fact that this drug can be used for a multitude of conditions even after Covid-19 outweighs, IMO, any potential bumps along the way. We know that interferon beta-1a works from the many years of IV data. And everything is backing the nebulised version being even better. So I think that even with any bumps in the road that may come, as it does with anything in life, the multi purpose of SNG001 makes it a winner regardless. Hope this answers some of your questions.

@gbk47. The nebulized form reaches the blood stream. It follows exact same pathway as the virus without the adverse side effects caused by the IV form. That's what makes it so special.

@JoeyDiamond. The medical world has really begun to see the potential of interferon beta-1a and it's use against COVID-19. The number of articles with it's positive use in critically ill patients in India, China, and Italy - among others - and the big uptick in mentions by doctors globally underlines that.

As mentioned before SNG001 is the superior version and would then be even more effective than the versions they are using.

Thank for for that clarification, gkb47.

SNG001 is the best version of Interferon beta-1a with by far greater safety data than any other version so it's good the IV versions are in trials because the more they trial the IV versions of interferon beta-1a the more they will see that SNG001 is superior.

:)

@Brysoa. The adverse side effects of IV interferon beta-1a has been known for years and is what has kept it from from properly soaring since it's discovery in the 70s. So I'm not surprised to hear the trial being stopped. However, even with the adverse side effects Rebif causes - it still made 2.51 billion dollars in sales in 2013.

Now imagine how useful and needed a patented nebulized version without the adverse side effects would be. And the high market value that would follow.

Interferon beta-1a is the best treatment for COVID-19. And Synairgen have the best version - which is patented both in nebulized form and nebulized form with steroids.

It's all great news for us.

@pmjh. It's you who deserves all the thanks :)

Part 3 of 3.

So as you see interferon beta-1a doesn't 'boost' your immune system. It does the opposite by stopping the over-activation of it while also stopping the virus from replicating and, in so, stops the autoimmune organ and tissue damage from occurring while also aiding in healing the damage that has been caused.

To put it simply:

Covid-19 basically gives you an autoimmune disease by over stimulating your immune system which makes it attack your own body.

This over-activation results in tissue and organ damage as your own body eats itself. This is what 'long covid' is. A long period where your own immune system is damaging your lungs, tissue, and organs.

Interferon beta-1a is your body's antiviral and anti-inflammatory stop to that process by stopping the virus from replicating and restoring the damaged tissue.

So now you see how it works.

And not only that - if you read the RNS from Synairgen on the 8th of September, reporting the results from their clinical trials, you would see that SNG001's effects are even stronger when used on patients who are on STEROIDS, like dexamethasone, and antibiotics. Which represents the most critical patients. And which is why they got the patent for use with steroids.

In conclusion, SNG001 can be given in several stages throughout a Covid-19 infection. In the beginning to stop the virus, during with dexamethasone, and after to heal and eliminate the over-activation of your immune system which causes 'long covid'.

It has got more legs to stand on than a caterpillar. While the 'other' therapeutics target single parts of the covid 19 disease; SNG001 directly targets the cause AND the symptoms. That is why and how it works.

And why it is so important.

Part 2 of 3.

In the first study they also look at people with existing antibodies towards Covid-19 and state that:

"antibodies against COVID-19 might represent a double-edged sword; beneficial by neutralizing the virus and detrimental by contributing to over-activation of the complement system"

In other words according to their research - antibodies, from either a previous infection or a vaccine, over stimulate the complement system and can cause further damage in your lungs and body by causing a chronic over-activation of your immune system which completely negates the potective assumptions regarding antibodies and vaccines. Showing why people are getting infected again with some a lot worse the second time.

And why people are getting lung and organ damage months after infection.

https://www.nature.com/articles/d41586-020-02598-6

In conclusion they say:

"The anaphylatoxins C3a and C5a and the terminal complement complex C5b-9 are the most potent inducers of inflammation, and inhibition of these should thus be prioritized. Thus, therapeutic inhibition on the level of the common pathway including C3 or C5 inhibition seems most promising in light of the results from this study."

Inhaled interferon beta, SG001, would do just that by completely counteracting their suppression of the body's natural antiviral and anti-inflammatory interferon beta and shows why if SG001 is administered at an early stage of the disease causes such a remarkable reduction (79%) of Covid-19 virus' effect by greatly reducing the length of the disease in your system and in so the length of the damaging over-activation of your immune system.

Here is an updated stream lined version of what I wrote this morning of anyone wants to use it:

Part 1 of 3

The following independently verifies SG001 as a main treatment of COVID-19. Most likely even over vaccines.

A peer reviewed study was published on the 17th of September regarding the cause of respiratory failure in Covid-19 patients. In it they lay out which pathways cause an inflammatory reponse in the body leading to respiratory failure, ARDS, organ damage, and death.

It shows that a long and systemic activation of the 'complement system' - a key component of the immune system is the cause of serious respiratory and negative effects of Covid-19. The complement system, that consists of proteins that are produced by many cells and organs in our body that continually circulate in our blood and tissue, are our 'first defence' against virus and bacteria. But a chronic over-activation of this system, as seen in lupus, causes damage by attacking all your body's cells in an attempt to 'heal' you.

An over-activation of our own immune system caused by the virus is in other words what damages our organs and the cause of mortality.

https://www.pnas.org/content/early/2020/09/15/2010540117#xref-fn-3-1

The pro inflammatory complement anaphylatoxins C5a and C3a are the main culprits by producing an over-activated inflammatory response caused by Covid-19.

Now what is interesting is that those two anaphylatoxins suppress the body's natural production of none other than interferon beta.

Without the anti inflammatory and antiviral protection of interferon beta - which stops the virus from replicating - your body is unable to defend against the virus effects and your chronically over-activated immune system causes considerable damage to lungs and organs. This is why older people, who naturally already have a large reduction of interferon beta, are at greater risk of mortality and respiratory failure. And why bats who have a high level of interferon beta are unaffected by coronavirus.

(Here you see the suppression of interferon beta by C5a and C3a: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398560/ and the anti-inflammatory protection that interferon beta gives: https://www.ft.com/content/743ce7a0-60eb-482d-b1f4-d4de11182fa9 )

So if you get Covid-19 you immediately need more interferon beta to fight the suppression of interferon beta and to halt tissue damage. Inhaled SG001, which directly targets the lungs, is the most efficient interferon beta treatment with fewest side effects by far in any treatment.

@phillgekko. I can write an extended version and post here later today that people can use to send around if they wish.

No problem, everyone. This really is a wonder drug with so many uses. And even better it works with all other therapeutics if needed so there really is no end for it's importance. Not to mention market value.

Go right ahead, PhillGekko. In the first line it should be 'verifies' instead of 'verify'. Just off an 18 hour shift so a bit tired.

Part 3 of 3.

So as you see interferon beta-1a doesn't 'boost' your immune system. It does the opposite by stopping the over-activation of it and in so stops the autoimmune organ and tissue damage from occurring while also healing the damage that had been caused.

To put it simply:

Covid-19 basically gives you an autoimmune disease by over stimulating your immune system which makes it attack your own body.

This over-activation results in tissue and organ damage as your own body eats itself. This is what 'long covid' is. A long period where your own immune system is damaging your lungs, tissue, and organs.

Interferon beta-1a is your body's antiviral and anti-inflammatory stop to that process by stopping the virus from replicating and restoring the damaged tissue.

So now you see how it works. And not only that - if you read the RNS on the 8th of September you would see that SNG001's effects are even stronger when used on patients who are on STEROIDS like dexamethasone, and antibiotics. Which represents the most critical patients. And which is why they got the patent for use with steroids. I can't believe people keep forgetting that.

In conclusion, SNG001 can be given in several stages throughout a Covid-19 infection. In the beginning to stop the virus, during with dexamethasone, and after to heal and eliminate the over-activation of your immune system which causes 'long covid'.

It has got more legs to stand on than a caterpillar. While the 'other' therapeutics target single parts of the covid 19 disease; SNG001 directly targets the cause AND the symptoms. That is why and how it works.

Wed

Part 2 of 3.

In the first study they also look at people with existing antibodies towards Covid-19 and state that:

"antibodies against COVID-19 might represent a double-edged sword; beneficial by neutralizing the virus and detrimental by contributing to over-activation of the complement system"

In other words according to their research - antibodies, from either a previous infection or a vaccine, over stimulate the complement system and can cause further damage in your lungs and body by causing a chronic over-activation of your immune system which completely negates the potective assumptions regarding antibodies and vaccines. Showing why people are getting infected again with some a lot worse the second time.

And why people are getting lung and organ damage months after infection.

https://www.nature.com/articles/d41586-020-02598-6

In conclusion they say:

"The anaphylatoxins C3a and C5a and the terminal complement complex C5b-9 are the most potent inducers of inflammation, and inhibition of these should thus be prioritized. Thus, therapeutic inhibition on the level of the common pathway including C3 or C5 inhibition seems most promising in light of the results from this study."

Inhaled interferon beta, SG001, would do just that by completely counteracting their suppression of the body's natural antiviral and anti-inflammatory interferon beta and shows why if SG001 is administered at an early stage of the disease causes such a remarkable reduction (79%) of Covid-19 virus' effect by greatly reducing the length of the disease in your system and in so the length of the damaging over-activation of your immune system.

I see a few people here - most notably Sparkle1 recently - don't seem to fully understand how interferon beta-1a works so here is a message on why and how interferon beta-1a, and SNG001, works.

Part 1 of 3

This independently verify SG001 as a main treatment of COVID-19. Most likely even over vaccines.

This peer reviewed study was published on the 17th of September regarding the cause of respiratory failure in Covid-19 patients. In it they lay out which pathways cause an inflammatory reponse in the body leading to respiratory failure, ARDS, organ damage, and death.

It shows that a long and systemic activation of the 'complement system' - a key component of the immune system is the cause of serious respiratory and negative effects of Covid-19. The complement system, that consists of proteins that are produced by many cells and organs in our body that continually circulate in our blood and tissue, are our 'first defence' against virus and bacteria. But a chronic over-activation of this system, as seen in lupus, causes damage by attacking all your body's cells in an attempt to 'heal' you.

An over-activation of our own immune system caused by the virus is in other words what damages our organs and the cause of mortality.

https://www.pnas.org/content/early/2020/09/15/2010540117#xref-fn-3-1

The pro inflammatory complement anaphylatoxins C5a and C3a are the main culprits by producing an over-activated inflammatory response caused by Covid-19.

Now what is interesting is that those two anaphylatoxins suppress the body's natural production of none other than interferon beta.

Without the anti inflammatory and antiviral protection of interferon beta - which stops the virus from replicating - your body is unable to defend against the virus effects and your chronically over-activated immune system causes considerable damage to lungs and organs. This is why older people, who naturally already have a large reduction of interferon beta, are at greater risk of mortality and respiratory failure. And why bats who have a high level of interferon beta are unaffected by coronavirus.

(Here you see the suppression of interferon beta by C5a and C3a: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398560/ and the anti-inflammatory protection that interferon beta gives: https://www.ft.com/content/743ce7a0-60eb-482d-b1f4-d4de11182fa9 )

So if you get Covid-19 you immediately need more interferon beta to fight the suppression of interferon beta and to halt tissue damage. Inhaled SG001, which directly targets the lungs, is the most efficient interferon beta treatment with fewest side effects by far in any treatment I have studied.

Strong week ahead with several big potential updates due.

A lot of good publicity for Synairgen, and the use of interferon beta-1a, over the weekend in the States and UK.

Great article in the Sunday Times putting the spotlight Synairgen and SNG001 which I think is part of a build up towards a larger announcement.

We have the peer review due any time and very possibly this week which would fit with SNG001 now being available on the market.

France and the UK are seeing all time high record numbers of infected, and with it hospitalizations, which means orders for SNG001, and safety important data, will be pouring in. Especially since there is a remdesvir shortage and no treatment even nearly as safe and effective as SNG001.

Synairgen are in advanced talks with several government agencies about the use of SNG001, which remember also has a patent for use with steroids, so updates are due there too.

The recent partnership with Numis brings with it a multitude of positive updates and is extremely exciting. I think we could be seeing some really big things happening from that alone.

The UK now has the highest death tally in Europe so I think we will see the government really jump on the SNG001 wagon - especially as France is properly rolling it out now. And vaccines far, far away.

Even if a vaccine would be made available today, the distribution is a nightmare and people would still not get it until next year.

The treatment of this pandemic, especially with the recent infection of Trump, has now shifted to the use of therapeutics more than ever and we know which therapeutic is number one - SNGOO1.

Record infections, hospitalizations, and deaths:

https://www.brusselstimes.com/news/134128/coronavirus-nearly-17000-new-cases-in-24-hours-in-france/

https://www.google.com/amp/s/amp.dw.com/en/coronavirus-digest-france-and-uk-set-record-daily-figures/a-55149529

Remdesvir shortage:

https://www.google.com/amp/s/www.telegraph.co.uk/news/2020/10/01/doctors-told-ration-remdesivir-nhs-hit-shortages/amp/