Member Info for Vander

My view is that most of the IP is pre-existing but will need further guidance from NT on this

This is from the AZ website:
What are the typical agreement terms?
The AstraZeneca Open Innovation programme seeks to utilise terms that facilitate participation, open collaborative brainstorming, problem solving and are consistent with well-established and tested academic-industry agreement structures (e.g., Lambert/miCRA templates in U.K. and NIH/NCATS CRA in U.S.), for example:
Pre-existing IP remains with the original owner
New IP follows ownership framework taking into account the contribution of each party and where possible using the well-established academic-industry templates
Publications are encouraged after allowing AstraZeneca to comment, patent(s) to be filed (if applicable), AstraZeneca confidential information protected
If the collaboration generates positive findings, AstraZeneca has option to negotiate a license to advance further towards patient benefit and commercialisation
For compounds ‘live’ in development, AstraZeneca minimally receives non-exclusive, royalty-free, fully paid license, with the right to sublicense without limitation, for all purposes for project IP
Ownership of project IP is based on multiple factors including regional/country standards, IP policies and the current development stage/status of the compound

Leister regarding IP, I was wondering if medimmune co- developed the optimised version using their high level technology and resources whether they would have a claim to some of the IP?

It seems to me that they should the optimised version of nuvec in all three arms of the studies ( ie medi, UoA and Eu ncl). I am wondering how they integrate the results of the three strands, because each will move product development on in its own way

One of the most promising inorganic materials for nanovaccinol-ogy and delivery system design is silica. Silica-based nanoparticles(SiNPs) are biocompatible and have excellent properties asnanocarriers for various applications, such as selective tumortargeting [72], real-time multimodal imaging [73], and vaccinedelivery. The SiNPs can be prepared with tunable structural param-eters. By controlling the sol–gel chemistry, the particle size andshape of SiNPs can be adjusted to selectively alter their inter-action with cells [74]. The abundant surface silanol groups arebeneficial for further modification to introduce additional function-ality, such as cell recognition, absorption of specific biomolecules,improvement of interaction with cells, and enhancement of cellu-lar uptake [75–78]. In addition, porous SiNPs such as mesoporoussilica nanoparticles (MSNs) and hollow SiNPs can be prepared bytemplating methods, which can be applied as a multifunctionalplatform to simultaneously deliver cargo molecules with variousmolecular weights [74]. MSNs with sizes in the range of 50–200 nmhave been studied as both nano-carriers and adjuvants for deliveryof effective antigens [79–81], such as those derived from porcinecircovirus [82] and HIV [83]. MSNs can be used to control the releaseof antigens by controlling the shape, pore size and surface func-tionalization [79,84]. Compared to solid SiNPs, MSNs have higherloading capacity for their larger specific surface area, and betterperformance in delivery and controlled release due to the tun-able hollow and mesoporous structure. In addition, MSNs can bedegraded which can then be excreted in the urine [85–87]. Withthese properties, MSNs show potential to become high-efficiency,controlled-release nano-carriers in future vaccine formulations

Sorry etin- predictive text

Good stuff Erin Research that’s worthwhile posting and addresses the underlying key questions

I agree with you Ozzie Let’s have a good weekend

Thanks slipperz Personally I find IanB reassuring. Where is he when you need him? One point was to allow multiple opinions on here or be subject to groupthink. Oman was an extended distraction. Hopefully trump will also be. He has helped create this opportunity for wsg however Ultimately discussion of PF’s competence is not relevant at this juncture- hopefully he is quietly pulling this off as we speak. Let’s hope for a positive rns in the coming days/ weeks GLA

Apologies PF has secured a big contract. I hope he wins the contract for all of is Good luck all

But I don’t know anything about airport security. I know about medicine and clinical research I only have two aim shares, and have only posted on these

N4p is by far my major holding. I was on holiday last week hence able to post a lot.. also do not work on Mondays. Otherwise post after work hours and on weekends Unfortunately now a bit addicted to posting. Will have to stop

I invested based on the dec23rd rns Initially I gullibly believed That PF was stating a fact that a contract had been agreed except for minor details and stupidly I did not realise that the country involved could be an international pariah Having said that I think the potential of this company is absolutely massive and I believe the Sanctions issue will be overcome. Regarding PFs abilityI have been reading posts about his incompetence for months from some of you guys. I don’t know if he is or isn’t. The SP had been widely acknowledged to have almost no downside risk. The implication of this by logic is that the market thinks there is no chance of success partly due to management incompetence PF is age 65 is that correct. If this first airport goes ahead do you believe he has the high level managerial and negotiating skills to fulfil the necessary expansion across the rest of the country? Whoever is in charge could develop this into a £100 million plus Mcap company. It could attract v high calibre successors. Only saying

I am trying to stimulate constructive debate There is some point to this- take the discussion over the country of contract origin for example. A broad perspective is a reasonable starting point. Knowledge of the operational management of SL was not necessary for this- I accept that knowledge of this and keyguard is important but less so if the ME contract comes to fruition I am sorry for being overly focused on the ME contract but I would like to make a profit on my investment. I am a newbie though and I know my place. I definitely do not want to deramp though can not prove it

I do not know PF as a person. His legacy to the company is safe and will be enhanced if this is successful. He is certainly a bold CEO but there are some concerns re competence. My only concern is that the contract goes ahead. We have no control over geopolitical events but do have shareholder scrutiny This is a massive opportunity but we have no transparency over how it is being handled We will ultimately get an rns which informs us of successor failure- if it goes wrong it will be blamed on trump

I think Iran lacks options and have offered this contract on a plate to wsg, presuming they are up to it It may be that wsg and PF are up to it and it should be expected that time is needed to sort it out My concern is the SP and market do not think PF is up to it. My main wish is for a mechanism to come into play if he is not coping with it, for another capable CEO to come in. This is a big job and contract now and will attract big players? Is that right?

Here is key question: Can a small company manage the challenges of operating in Iran, in an airport that is an order of magnitude bigger than any they have managed before and also do so under the additional restrictions by sanctions. Ie the difficulties in upscaling are compounded by the sanctions A key question is whether the management is up to it Sir Tony and pippa are good at glad handing but not sure how helpful they are Is PF up to it along with the new CFO? There is a massive prize hanging in front of them I realise that this is PFs life dream but is he up to this bit of the job You guys have met him. What do you think? This may be a stupid thing to say but if he is not up to it should he be replaced?

Btw I think the seriousness, attention to detail, hierarchy amongst the LTH, and lack of transparency reflect that we are investors in a security company

I hope you don’t mind if I make a final point on this. some of the people here are v serious and detailed in their knowledge of wsg. You correct each other v well on the detail, and have innovative research strategies such as sourcing satellite photos and obscure job adverts. However sometimes what is missed is the important broader questions, though not as broad as jcpoa viability and trump deal making Hence the question what sort of ME country will offer such a big contract to a small company like wsg in lieu of bigger competitors was never answered. Hence everyone charged off down the road after Oman- it was all a bit nuts! Now the key questions are different. We have identified the key sticking points, but lack evidence of progress. Unfortunately the SP indicates the market is not convinced- why? Isn’t this an elephant in the room that newbies need to know/ discuss I am just a newbie a hole but I would like More updates from PF. As mentioned by slipperz there has been nil for a while. They are they operating under confidentiality rules. Without transparency they have licence to manipulate the investors and we end up barking under the wrong tree

Thanks joe. I am a relative newbie and so still idealistic I don’t have much to add to the skills already on here- a lot of clever people. However, I think sometimes groupthink can dominate eg 6 months of Oman obsession. Qatar and Jordan were secondary favourites. Why did no one mention Iraq, Afghanistan and obviously Iran