Member Info for tyche100

Maybe the UKOG want to make some money on the false spikes the eyes keep making for you on ANGS, You can see in the chart from last week made by Pboo which I call 'Heids swiiming pool' swiftly followed the next day by by FOTH which I call FOTHS beer money....Carefull Other 'Eyes' are watching.

DHC, I really hope people don't buy on the back of your dispicable ramping. Fact is UKOG have a plan which is great, however its a plan thats all it is. Its obvious that its difficult to get the weald basin to flow, HH could be a flook for all you know.

Yeah right PITW...I wonder which poster you used to be.

I see many posts about how BB talk in no way makes prices move, here is a prime example that is incorrect. Seems like the eyes are taking turns now to make some small change

Tut Tut FOTH illigal move.

Nope it didn't. Nice little spike created then sold into, way to obvious. I await RNS.

Pboo, Not sure why you are posting that to me I don't doubt there was a tanker. I prefer to wait for RNS from the company which IMO hopefully Vonk will deliver after market hours one day to catch out some people.

I agree, RNS needed, this is just the twitter team making a few pennies, still being played at the moment but not for much longer hopefully.

I bet you did Heid........funny that. But good luck anyway.

Crikey Lawson you couldnt of picked a more volitile share! Good luck to you

Sareum Holdings plc

("Sareum" or "the Company")

Sareum licence partner for SRA737, Sierra Oncology, to Present at the DNA Damage Response Therapeutics Summit on 30 January 2019

Sareum Holdings plc (AIM: SAR), the specialist small molecule drug development business, notes that Sierra Oncology, the licence holder advancing clinical cancer candidate SRA737, has announced that its Chief Scientific Officer, Dr. Christian Hassig, will present "Addressing Intrinsic & Acquired PARP Inhibitor (PARPi) Resistance Through Chk1 Inhibition" at the DNA Damage Response (DDR) Therapeutics Summit in Boston, MA. The presentation is scheduled for 9:00 am Eastern Time (ET) on 30 January 2019.

Further extracts from the Sierra Oncology announcement are below and a link to the full announcement can be found by clicking here.

"Targeting components of the DDR machinery that regulate replication stress, such as Chk1, represents an attractive therapeutic strategy to address both intrinsic and acquired PARPi resistance," noted Dr. Hassig. "For example, CCNE1-driven tumors, frequently found in high grade serous ovarian, breast and endometrial cancers, are associated with high replication stress and are generally insensitive to PARPi therapy. We have demonstrated that our Chk1 inhibitor, SRA737, plus low dose gemcitabine is highly effective in CCNE1-amplified preclinical models, where low-dose gemcitabine induces an additional exogenous form of replication stress further enhancing sensitivity to Chk1 inhibition. Moreover, PARPi acquired resistance is driven, in part, through increased replication fork stabilization and partial recovery of homologous recombination repair, two processes regulated by Chk1. As such, our preclinical results suggest that combining PARPi with SRA737 may prove effective in treating this significant emerging clinical issue."

Sierra Oncology is a key sponsor of the DNA Damage Response Therapeutics Summit, which will gather leading stakeholders from across drug development over two days to discuss how to advance the therapeutic potential of targeting DNA repair pathways.

For further information, please contact:

Just got a SAR RNS notification but can't see it.

offtheball, He's just another member of the twitter team been doing it for years! Why they can't wish all weald companies all do well is anyones guess.

Me too, I took a massive hit here, sold the lot on the morning of the bit. No trust in any BOD now. All this will put PI's off in future.

I agree baits, It's amazing what a little bit of power will do to some people, It's like watching teenage girls locking their facebook then unlocking when they have a bit of gosip. Grown men PSML IMO

NIce one Baz, can you turn down the sub woofer in your XR31 there are men at work here LOL

Thank you

Albinio74, whould you happen to know when the TBS is due, I remember hearing in an interview this was expeted before xmas

Too right GCCRa, Comsat seem to like AVN also

"#ThrowbackThursday - As 2018 is winding down, we like to reflect and see how we’ve grown. Today, we are taking a look back to August when we signed our partnership with Avanti. This partnership enables the collaboration on service development for US Government and aviation, and we are excited to work with Avanti in 2019.

I doubt it Cassius, All part of the new BOD's challenge going after commercial contracts with MNO's, Govs and other operators which so far in their short time at the helm they have done a great job. AVN need more heavyweight contracts such as the VIASAT deal and who knows they may sell all the capacity on Hylas 3 in one hit which would be a massive bonus, hopefully Hylas 3 will be active later this year. Still on the sidelines at the moment for me. GL