RE: RNS2 Jul 2020 13:10
Having red the RNS I have actually warmed to this trial now. I did think the association with asthma was a bit loose but there are a few positives in there that I was ignorant of...
1. Absolute key statement “enrolling up to 90 patients admitted to hospital with COVID-19 in the UK” . I did have an oh sht moment thinking it was aPlymouth area trial! As would be difficult to get numbers.
2. “The primary endpoint of the trial is the mean change in clinical status score as measured by the WHO Ordinal Scale for Clinical Improvement.” This should not be too arduous because out of the blue we have....
3. "Immunomodulatory intervention in COVID-19 is supported by recent positive results from the UK's RECOVERY trial, showing dexamethasone reduces the risk of death in hospitalised patients. We believe MRx-4DP0004 has a mechanism of action that may be complementary to that of dexamethasone, which has now become standard-of-care across the UK's National Health Service (NHS).
Now imo that is a significant positive. Must say I am eating my hat this morning as I thought this news would have taken out the sellers but like I maintain. Forced selling is an opportunity for PI’s. There is nothing derogatory thus far with the science other than a delay. But when you read the last paragraph.....
“The Company has six clinical studies in progress, namely a Phase II clinical study of BLAUTIX® in Irritable Bowel Syndrome (IBS), a Phase I/II study of MRx0518 in combination with KEYTRUDA® (pembrolizumab) in solid tumours, a Phase I study of MRx0518 in a neoadjuvant setting for patients with solid tumours, a Phase I study of MRx0518 in patients with pancreatic cancer, a Phase I/II study of MRx-4DP0004 in asthma, and a Phase II study of MRx-4DP0004 in patients hospitalised with COVID-19. Preclinical-stage programs include candidates for CNS disease such as Parkinson's disease and other neurodegenerative conditions. The Company has a research collaboration with MSD, a tradename of Merck & Co., Inc., Kenilworth, NJ, USA, to discover and develop Live Biotherapeutics for vaccines.....”
Just how many shots on goal for £44m mcap and £22m cash (ish)! Plenty of time to buy now and de-risk later here imo. Just average in slowly with a little patience. GLA. Usual caveats.
Trek