RE: Biontech/pfizer put the price up of booster23 Oct 2022 10:45
. . . . . "Indeed, several randomised controlled studies have found that aspiration prior to intramuscular injection can lead to increased pain in children.2 However, this association has not been confirmed in adults.3
The association of the AstraZeneca COVID-19 vaccine with vaccine-induced thrombotic thrombocytopenia has raised concerns about vaccine safety. Although this side effect occurs in only 4–10 persons/million vaccinees, its mortality is up to 20%. It is unclear whether aspiration plays a role in this, but there is evidence that intravascular injections of vaccines containing adenoviral vectors are associated in preclinical models with coagulation disturbances, multi-organ failure and death.4 In addition, we should note that the European Medicines Agency has acknowledged a possible link between inadvertent intravascular injection and thrombotic events associated with the AstraZeneca vaccine, although it also admits that this link has not been formally evaluated.
In terms of efficacy, there may be a risk of a rapid drop in immunogenicity with the intravascular injection of vaccines due to rapid splenic phagocytosis, loss of adjuvant into the muscle or elimination of the depot effect.
Finally, although several reviews have found no adverse effects associated with the aspiration-free technique, these reviews have limitations as they focus almost exclusively on pain, do not assess long-term side effects, do not consider a decrease in vaccine efficacy, and do not include a considerable number of patients: they therefore lack the power to find unusual side effects.5
In conclusion, we must reopen the debate about the appropriateness of aspiration and the search for evidence should continue through robust research designs to determine the most appropriate technique, especially after the European Medicines Agency recognised a potential link of this technique to the severe thrombosis phenomena observed in some COVID-19 vaccines. Rigorous experimental studies are needed to study in depth the side effects of intravascular administration of vaccines and to compare the results and complications of both techniques, as well as prospective studies analysing the incidence of blood reflux in the aspiration technique. In short, to ensure that the safest and most effective technique is used to minimise the associated risks, specific protocols with solid scientific evidence must be agreed upon to allow standardisation of practice so that it is not left to the discretion of the individual professional."
Indeed, it should not be left to the discretion of the individual Patient either. ATB
Sign In
Follow the stocks
