Tranilast and COVID-1914 Jul 2020 12:19
Bit of a quiet day, so having a dig around (somewhat out of frustration) and dug up this little number. Apologies if its been here before.
I can't remember if the trial it refers to is the same as the one previously mentioned here. But either way its a good reminder that not only does NXP002 relate to IPF as a result of COVID, but there is an opportunity for it to relate to other aspects of the treatment of the virus.
https://www.jimmunol.org/content/jimmunol/early/2020/06/02/jimmunol.2000513.full.pdf
"Several repurposed compounds with regulatory effects on inflammasome activity are currently being appraised in clinical
trials as treatment for COVID-19.
An example is tranilast, a tryptophan analogue that has a direct inhibitory action against NLRP3 (52), which is currently undergoing a randomized control trial in COVID-19 patients (registration number: ChiCTR2000030002 on the Chinese Clinical Trial Registry). Tranilast is initially approved for the treatment of allergic and inflammatory diseases such as bronchial asthma, atypical dermatitis, allergic conjunctivitis, keloids, and hypertrophic scars (53). Now, its effectiveness has also been recognized in the treatment of fibrosis, proliferative disorders, cancer, ardiovascular problems, autoimmune disorders, ocular diseases, diabetes, and renal diseases (53).
Tranilast might be an attractive intervention for COVID-19 patients with comorbidities, given its wide array of therapeutic effects with minimal side effects""