RE: Interesting11 Aug 2020 23:21
“We further expand the model to include pharmacodynamic effects of the anti-inflammatory drug tranilast, and our numerical simulations demonstrate that increasing drug levels result in delayed NLRP3 inflammasome formation, and by extension, delayed cell rupture...
...As we have shown in our simulations inclusion of the drug tranilast can delay the formation of the inflammasome, and therefore may provide a method of switching cell death mode.”