Member Info for Saxondale

Posts seem to be disappearing and appearing again tonight - LSE needs to put another 50p in its meter .

Just a small detail , but on Clinicaltrials.Gov , the REMAP trial is shown as a phase IV trial .

Definition - Phase 4 is sometimes written as phase IV. These trials are done after a drug has been shown to work and has been licensed.
Phase 4 trials aim to find out:
more about the side effects and safety of the drug
what the long term risks and benefits are
how well the drug works when it’s used more widely

So another hint of the confidence REMAP have in including Farons drug into their program .

Does anyone have an opinion what may happen to this project given the future prospects of gold prices ?
At what point does the gold price allow this to get the green light , and did anyone get to the bottom of the BVI company that they seem to have created to keep it at arms length ?

Short report from front line of ICU in the UK .
Just shows how the doctors are so desperate for an effective drug to start turning a corner in survival rates .
If Farons drug can do what we expect , I think we will all be very proud at the end of this.
and Markku should get the nobel prize
https://www.bbc.co.uk/news/av/health-52190961/coronavirus-inside-an-icu-fighting-covid-19

Yes and only 3 days trading then 4 days off , and a week is a long time with this pandemic .

Afternoon all , first post on Hummingbird , but been invested on/off since the heady days of 2017 when the construction was just completing . Hung in through all the disasters , but finally threw the towel in last Autumn with quite a loss to find excitement elsewhere . That paid off to a certain extent , but i always followed this share . No more Bunker Hill fiascos , and despite a fairly cringe worthy share options scheme , the company seemed to be paying attention at getting the bottom line sorted out - and to start looking after shareholders . The figures were getting better , finally the AISC costs were coming down , and lucky for them the Gold price gave them a leg up . After seeing some visible proof that they are actively getting on with LOM expansion , and the predicted production this year ( Covid 19 permitting ) , I decided time to get back in and be part of the success Hummingbird promised all those years ago .
I'm about even at the moment , the take off last month was obviously a false alarm , but anyway it got my attention and back on board .
I'm hoping Gold will rise nicely , maybe not too high otherwise we may all be experiencing the apocalypse . A nice steady $2000 would be ideal for a year or two .
We seem to be lagging behind some others in this gold rush , The next set of figures should help , but most of all , a great LOM extension should really do it . That was the one RNS I didn't want to see while i was out of this share lol.

NCYT is a good example of how far the SP can go when a relatively small Mcap company find themselves producing a class product that the world is desperate for . Sound familiar ?
I had a small punt there at 90p , chickened out way too early , but bought back in a bit on Thursday . I just couldn't see it failing to rise with Govts promising so much .
Certainly more interesting over there today than here that's for sure , but whats a day in the scheme of things when you have this potential .
Holders here may have to knuckle down for a week or so , unless Faron give us another update RNS about Clevegen or the A0C3 development .
But when the RNS comes through about Traumakine - what a day that will be !

105 COVID 19 patients entered into REMAP trial as of this morning.
That was up from 60 odd last Friday .
You'd think on average we'd be getting at least 20% of those - and thats just the COVID 19 ones . I'm sure there will be others in the REMAP trial with just pneumonia/lung issues .
And as its adaptive - we could get more as progress is made.

I'm guessing that all these various forms of Interferon Beta have varying effects depending on the application .

Faron have obviously spent best part of 10 years looking at this protein and the most effective way of administering as a therapy for ARDS , and have found Intravenous is the best .

The Interferon spray which has been aimed at MS sufferers , may have a benefit by reducing inflammation in damaged nerves .
Traumakine works from the inside out , specifically targeting CD73 synthesis to reduce vascular leakage.

By the time a patient is in ICU , with damaged lungs , I wonder how effective a spray would be compared to having the protein dosed from the inside to every area ?

https://www.thelancet.com/pdfs/journals/lanres/PIIS2213-2600(13)70259-5.pdf

That sounds right Itsall
The ball is in their court , but if the offer is good enough who knows .
They've obviously had offers before , but aren't giving it away , and like Zen has been saying , the buying in price just got a lot higher .

EMA have given recommendation for Remdesivir to be given compassionate use for patients across the EU who are not currently on the trial .
I guess this is because they have seen signs of it being effective , so feel it would be beneficial to allow doctors across the EU to use it if they feel necessary - and give what they call a harmonised approach to all EU member states.
Faron had offered this in the past before , leading into the Interest Trial for the EU , and were considering it for US .
It all adds to quicker results back too .

I'm just curious now about Partners . Would the original plan have changed now we are in such a different situation ?
They must have been having some pretty big discussions of late , considering they know it will work .
The FDA Caliber trial was to be funded by third party or parties
That trial is almost irrelevant now that REMAP is fast tracking a global trial for them - funded by International Govt agencies.

So - IF we start getting quick positive feedback on REMAP - who is the preferred type of funder - a big Pharma with manufacturing clout and expertise , or could Faron enter into some sort of JV or licensing agreement .

The numbers banded about must be massive - just look at testing equipment/ PPE . The numbers are off the scale.

Plus we will have a drug therapy for something that isn't going away . Covid 19 will die off eventually , but ARDS , pneumonia and other virus's will be around.

International regulators met on Friday to discuss the progress on possible medicines for Covid-19

25 countries , and including the FDA , EMA , ICMRA , Japan and WHO all there .
This is the second such meeting , first one was held by FDA and EMA on 18th March .
To discuss progress on medicines in trials for Covid 19.
It was organised by the EMA ,

So it looks to me like they are are all getting themselves on the same page , so that once they get a drug they want to use , the regulatory bodies can all act as one .

And we are one of the best bets - proven in combating ARDS already in PHASEI/II and III ( posthoc )

https://www.ema.europa.eu/en/news/international-regulators-discuss-available-knowledge-supporting-covid-19-medicine-development

How about ' Taldyaseu ' ?

Maybe its because some of the other drugs are already on the market with a brand name , and are just being trialed as a Covid-19 possible drug. So its easier to talk about them in their marketed names . Traumakine still unmarketed , and so just gets its scientific name . Thats just a guess .

Yes great to have a knowledgeable guy and a local in Finland who picks up on the subtle details .
95 new patients and counting with Covid-19 as of last night on REMAP .
Should be 200 + by end of next week I'm guessing , more if they have doubled hospital sites involved
Plus you have all top UK medical experts making plea for volunteers to take part in trials , although granted the Traumakine patients will be ones already in ICU or about to be , so not so much volunteering there .
I had a feeling that last week would be a watershed moment for Faron.
You couldn't really ask for more if you were trying to get your drug approved and marketed pronto.

Good find Nothing , I reckon we will be seeing a lot of news stories about REMAP ( the most crucial end of the patient danger zone ) . I just hope they let the clinicians get on with it , and that we don't get some wind bag from Downing St promising that every one in the Uk will be cured by next Wednesday .

Great post Mayfly
This share and the story is making life a lot more bearable at the moment .
If this comes off , I'm gonna get a T shirt made with FARON on the front , and YOU'RE WELCOME on the back .

That's great news - this trial is growing exponentially .

This is Zens house - he built it .
We just live here
He's seen off some right Fu**wits over my time here .

Having said all that , maybe the real rise in the SP is because we have a real contender of a multi cohort cancer drug ?

and don't get us started on the secret weapon

Gar , because the US wasn't part of the REMAP program ( started a long time ago ) .

US have their own institutes etc , but seem pretty insular when it comes to global programs .

Don't worry , they'll get Traumakine , but they won't be at the front of the queue

FDA approval for phase 3 , but we are essentially into something bigger than that already .