Member Info for RorkesDrift

From the British Society of gastro enterology

https://www.bsg.org.uk/clinical-resource/bsg-consensus-guidelines-on-the-management-of-inflammatory-bowel-disease-in-adults/

Statement 33. We recommend that active Crohn’s colitis can
be treated with an 8-week course of systemic corticosteroids to
induce remission (GRADE: strong 100% agreement)

Statement 37. We recommend that moderate to severely active
uncomplicated luminal Crohn’s disease should be treated initially
with systemic corticosteroids (GRADE: strong recommendation,
high-quality evidence), but we suggest that those with extensive
disease or other poor prognostic features should be considered
for early introduction of biological therapy (GRADE: weak
recommendation, moderate-quality evidence. Agreement:87%)

Hi. I think you may have misinterpreted my position on steroids. I know they don't work for every patient. Nor does infliximab or any other current and probably future therapy. IBD is an awful disease and huge strides are being made - we need to get there as fast as we can but some products will end up being red herrings. I hope as an investor TILS isnt one but I'm not going to drop healthy sceptismn.

You mention the excellent TILS results. What are they and how do they compare to steroids. I know neither class is 100% effective in 100% of patients - health economics will be important as will the position of various products as first line etc. Would you suggest we stop using 5-asa because they don't work 100% of the time in every patient

https://www.cochrane.org/CD006792/IBD_corticosteroids-for-induction-of-remission-in-crohns-disease

CEO did a number of activities when the placing was on. The information provided was at times "spun" eg results in Crohns didn't look great if you consider cost and effectiveness of 40mg pred tapered over 8-12 weeks. PIs are unlikely to be able to effectively critique these statements and take them at face value. IIs though do have access to the right expertise and furthermore have direct access to the BOD to illicit further info.

I am more relaxed because those IIs did invest. However, it is not appropriate to spin part of the story, bank the money and then go into silent running. For example the Chairman stated StemprintER worth £200M - where did that number come from, has it been verified.

Has a shareholders we actualy have the right to any information provided to any other share holder. I am sure they will have asked the questions and therefore you can request the same info. What's more, it is simple. Just write to either the CEO or the chairman informing them you are a shareholder. The email address is

info@tizianalifesciences.com

Not just cake but dough too

I'm thinking I may have over packed that last carrot

That takes the biscuit

Hey I'd rather be fully informed

Covid breathenomics

Wiggly you is a star.

Centurion status on its way

In the middle of the 19th century, there were four outbreaks of cholera across England. In the 1854 London epidemic the worst-hit areas were at first Southwark and Lambeth but Soho only had a few, seemingly isolated, cases. On the 31st August though "the most terrible outbreak of cholera which ever occurred in the kingdom" broke out. During the next three days, 127 people living in or around Broad Street died. Most familes were effected and over the next few days 127 people died Families fled leaving the streets deserted but by September 10th 500 people had died
Dr John Snow, had recently speculated that cholera was spread by contaminated water but medical authorities at the time dismissed his ideas. He lived very close to Broad Street and interviewed many of the families. He worked out most of them drew their water from the same pump. Snow later used a dot map to illustrate the cluster of cholera cases around the pump. He also used statistics to illustrate the connection between the quality of the water source and cholera cases.
As an experiment the parish removed the handle from the water pump. The number of cases dramatically fell. John Snow’s work led him to become the father of epidemiology.

Pe model I think also requires recurring income.

That said LG have extended project - can we assume early resukts look promising and their scientists have had a good look

I presume you mean LG - meaningful amounts but...

Where do you get the coming year from?

Have you applied any discount for risk?

https://giphy.com/explore/on-my-way

UKsteve - its the same on Avacta - Alex coming over complaining about someone posting about Vn on the BMN board. How's that work?

How much will they shell out for that?

Did you see CEO latest tweet. (Well retweet).

Amazing IF true

I thought it was $55M x 2?

Anyone else thinking the guys who signed this on the other sued also know how the first project is going....

Ergo double underlined..

Is it possible to be in both

Oh hang on....

Thanks for posting