RE: Reflections16 Jun 2025 22:01
Span,
Ref your post 16:04, 'Tim saying Avion deal alive, so meaning Avion conducting trial, that's not what he said in interview.' Let's be clear, Tim saying Avion deal alive does not mean Avion conducting trial. According to Tim, Avion are still in with their Lupazor/P140 $25m trial fund. However, in response to my question about Avion, he did appear a little less confident in his response than with others.
Turn the clock back to April 2018 and the P3 trial failure. Tim acknowledged at the AGM that this failure was entirely down to IMM. My interpretation of his explanation is that the trial failure was simply down to wrong dosage, wrong cohort profiling and an assumption that P140 (at the time) was a panacea for the treatment of SLE. Check-out the symptoms of SLE and the difficulty in diagnosis thereof and it is fairly obvious that one size does not fit all. To me, this admission from Tim to a live audience was quite astonishing given his reputation for smooth talking, detail light delivery.
It is clear that there has been a delay in the Avion lupus trial but reasons for that delay are now clearer given the further information about the P140 research and, to me, make perfect sense. The research conducted by Immupharma Bordeaux over the last 18 months has not only provided great value for the treatment of autoimmune indications but also the diagnosis. It is these findings which are being factored into the P140 trial for SLE and which, as a consequence, will result in a stronger trial less likely to fail.
Span again in post of 13th 17:19 claimed, 'I think Tim alluding to nothing near term and lanstead if they selling will drive sp back into 1's' Tim was not alluding or stating nothing in the near term!! Let me reiterate what has been said by other attendees. Before the 31st Dec 2025, so within the next 6 months, IMM will deliver on 2 fronts:
1. Patent filing which will cover new discoveries and, as a consequence, make a licence agreement with IMM for P140 that much more attractive.
2. A deal. No details on what that might look like but could I suppose be an exclusive licence for P140 on the Isle of Man or, more likely, somewhat larger scale.
We won't know any patent details until it's filed or of the deal until it's done but this will happen, according to Tim, within 6 months which, given the length of time LTHs have been patiently waiting would, I suggest, is most definitely near term.