Member Info for RayPointer

Thank you for your initial research Bermuda.

IMO, the positives of having 2 large investors with indications that they are here for the long haul has positives that easily outweigh any negatives.
I look forward to your full research.

LOL

Yes, excellent post.
It sounds like he knows quite a lot about Redmile and he also reckons that it is beneficial to have both Vulpes and Redmile as investors.

We do not know if Scancell have had commercial discussions with BionTech over TCR with moditope epitopes.
It is a research collaboration with BionTech having first dibs at an exclusive TCR/moditope licensing deal if they like what they see.

https://www.scancell.co.uk/scancell-to-collaborate-with-biontech

"Upon completion of these studies, BioNTech will have the exclusive option to enter into a licence agreement for the development of cell receptor based therapeutics that are specific to Modi-1 epitopes. "

You could be right Dalester.

Here's an article supporting the theory that vitamin D reduces inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070857/

I wouldn't like to comment further since I am no expert.

ATB to you and your wife.

https://www.frontiersin.org/articles/10.3389/fimmu.2017.01160/full#:~:text=We%20previously%20discovered%20that%20cytotoxic%20CD4%2B%20T%20cells,and%20disability%20in%20an%20animal%20model%20for%20MS.

This is an example of how dangerous cytotoxic CD4+ T cells can be. In this case it is without CD28 expression. These researchers are postulating that suppressing the formation of these cells can stop the progress of MS.
So a cell that Lindy says is "amazing" when clearing tumour cells also appears to be devastating for MS sufferers.

Alex

I would think that Scancell would want a large majority of the £15 mill to go towards their cancer vaccine trails and development.
They will be looking towards other funding for the Covidity development and trials.

There are a large number of Covid19 vaccines being developed. I'm not saying that Lindy's vaccine won't be one of the best but in moditope they potentially have a game changer unlike anything that currently exists.

All IMO of course.

Great news C7.
Really happy for you.

Yes, it may have caused less confusion if they hadn't numbered the stages.

To be clear
This website has defined the stages as
1 - exploratory
2 - pre-clinical
3 - clinical (human trials) this is subdivided into phase1/2/3
4 - approval
5 - production

We are at stage 2 - pre-clinical as are the majority of vaccines.

This is quite an old article but may well be relevant to the fight against Covid19.

https://www.theguardian.com/science/2010/nov/01/viruses-immune-system-antibody

"But the new study has shown that for many viruses, antibodies work in a very different way. Instead of preventing viruses from infecting cells, the antibodies follow the invader inside and co-ordinate an immune attack from within."

I wonder if this research is on-going.

Morning Ivy

Lets not forget that Lindy is also targeting the spike protein in 2 ways:

https://www.scancell.co.uk/covidity

"T cell epitopes from N and S proteins predicted to bind to both MHC class I (for the cytotoxic CD8 Tc cell response) and MHC class II (for the CD4 Th cell response);
Inclusion of trimeric RBD region of S protein to focus neutralising antibody response to block virus entry via the ACE2 receptor;"

So, a 3 pronged attack.

Morning Wild

https://www.reuters.com/article/us-health-coronavirus-science-idUSKBN22U2PC

"Furthermore, some people who never had COVID-19 nonetheless had T cells that could attack the virus, Crotty's team reported on Thursday in the journal Cell. This suggests that past exposure to other coronaviruses (such as those that cause the common cold) had somehow primed their T cells to recognize and attack this new coronavirus. "

This all fits in with Lindy's theory that all coronaviruses have a near constant N-protein and hence why this becomes one of her targets.

Apart from "s**t all over the board" it's exactly like playing chess with my grandson.

Welcome Alexios. We like stupid questions.
We also like to argue occasionally.

LL
I have been developing a trading program for some time.
I started with absolutely no experience of trading but bags of IT experience.
I am finding that, as with any computer program, the quality of the data is key. I do feel that I am slowly making progress but paid work tends to interfere.
Literally hundreds of strategies out there and I'm certain mine is a new one.
Good luck

I don't know if this has been posted previously

https://privatefunddata.com/private-funds/redmile-biopharma-investments-i-lp/

Interesting to know that the fund is 44% invested by management.

"I think everyone is/has finally come round now to the importance of triggering T-cells, especially after the initial Oxford results, so IMO it's going to put a lot of focus on Nottingham/Scancell very soon, in fact it may be happening as we speak?"

Let's hope so WTP. Lindy has been working with T Cells for many years.

In cancer, T Cell research is very much in the forefront with TCR and Car-T as well as vaccines.
In contrast, this does not seem to be the case in viral infection research. So a platform like immunobody may be just what is required to stop Covid19.

Interesting article dragon.
But no mention of avidity, clonal expansion or indeed activation of T Cells that are the hallmarks of immunobody.

Here's the link to register for the webinar

https://event.webinarjam.com/register/502/ryy72s05

Apologies if already posted.