T Cells and the N protein6 Jan 2021 20:56
Here's an interesting article that suggests that the N protein is a good target for T Cells.
https://www.nature.com/articles/s41586-020-2550-z
"SARS-CoV-2-specific T cells in COVID-19 convalescent individuals target multiple regions of the N protein."
This bit is vital
"Thus, SARS-CoV-2 N-specific T cells are part of the T cell repertoire of individuals with a history of SARS-CoV infection and these T cells are able to robustly expand after encountering N peptides of SARS-CoV-2. These findings demonstrate that virus-specific T cells induced by infection with betacoronaviruses are long-lasting, supporting the notion that patients with COVID-19 will develop long-term T cell immunity. Our findings also raise the possibility that long-lasting T cells generated after infection with related viruses may be able to protect against, or modify the pathology caused by, infection with SARS-CoV-2."
This is evidence that Lindy's approach may not just protect against Covid19 but also against other related viruses.
But how long do these memory T Cells last?
"Next, we showed that patients (n = 23) who recovered from SARS (the disease associated with SARS-CoV infection) possess long-lasting memory T cells that are reactive to the N protein of SARS-CoV 17 years after the outbreak of SARS in 2003;"
It is worth reading the whole article if you are that way inclined. But also remember that Immunobody (and hence Covidity) activates particular T Cells as determined by the design of the vaccine. Multiple targets for a single protein can be determined and included in the vaccine. In fact, from memory, SCIB2 has 16 targets all on the same protein. So, Lindy may well have included multiple targets on the N protein. It should also be noted that even without Avidimab the activated T Cells have very high avidity. This has already been proven with SCIB1.
We have to wait and see, but it may well be that well chosen targets on the N protein coupled with the high avidity T Cells may be enough to knock out the virus on its own. Then the memory T cells could be very long lived.
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