Member Info for RayPointer

Good afternoon C7.
Have a great Christmas everyone and especially you C7.

It's been a good year for Scancell and although the 1 year chart looks erratic it is looking very positive. Here's hoping for an even better year in 2021.

Some predictions for the new year:

Cancer trials to get underway again
The Covidity trial is a real winner
Chelsea win the premiership with Burnley 2nd

and then in Jan 2022 Honours list the N protein gets a knighthood

Yes 2021. I'm not into time travel :-)

I rarely make SP predictions but the JLP SP should creep a little higher in 2012 :-)
Have a good Christmas everybody.

Hi Shareguard

My understanding is that the peptides in no 6 in the diagram are actually part of the the drug itself and are not used to gain entry into the target cell.
The peptides Lindy talks about come into play at no 1 on the diagram. They will be on the surface of the nanoparticle and their roll is purely to help gain access to the target cell and are not part of the drug itself.

So IMO, peptides to gain entry and a separate set of peptides that are part of the drug.
ATB

Hi Shareguard

This may be of interest to you

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359574/

The article explains the use of peptides in drug delivery.
From the introduction:

"Recently, peptides achieved resounding success in drug delivery and in nanomedicine smart applications, thanks to these innovative approaches. These applications are among the most significant challenges of recent decades in transporting drugs only to pathological tissues whilst other districts in the body are preserved from side effects. This specific feature allows the reduction of unwanted drug effects and increases the drug efficacy [2]."

I believe this is the route Lindy's team are going down for drug delivery. The peptides make the drug delivery more targeted to the cells where you want the drug to enter.
As far as I know the system developed by N4P does not use peptides but feel free to correct me.

LL
Yes, let's hope this is sorted soon in the new year.

Boris is considering a temporary change to the national anthem

"Don't stand so close to me" by the Police is his preferred choice

The indications are that Scancell are using the delivery system developed by the Nottingham Uni School of Pharmacy.
Didn't Lindy at one point say that the next job was to choose the peptides? I take this to mean the peptides for the delivery system.

Here's a PhD thesis on a project using the peptide delivery system.

http://eprints.nottingham.ac.uk/50996/

This particular thesis was not about delivery of cancer drugs but the principles are the same. How to gain entry into specific types of cells. It looks like the peptides used to gain entry into the cells vary according to what type of cell you want to gain entry to. So I would imagine the work involved is to determine the best peptides for the vaccine to gain entry into soft muscle cells and also antigen presenting cells. There may be 2 sets of peptides.

It's fascinating science in its own right and hopefully the researchers are not far away from the best solution. Lindy did say in her AGM presentation that the work was going well.

I'm not sure how the pricing works.
That price is quite a bit lower than yesterday's close which seems a bit strange given today's rise.

WTP

You can buy Scancell in the US over the counter.
This has been the case for years

https://en.wikipedia.org/wiki/OTC_Markets_Group

The first dream was so popular, there's bound to be a sequel.

Miavoce
That's the funniest post i 've read all year. :-)

Are you predicting a pike in the share price?

Just trying to bring a little light to the people who live in Whales.

"Plenty more fish in the sea"
This is what Boris keeps telling the EU :-)

As I understand it, it is not the delivery system that needs to be developed, that has already been done.
It is about choosing the peptides that are best for infiltrating the cells (soft muscle and APC).

https://nottingham-repository.worktribe.com/output/872600/controlled-release-of-g-ag-binding-e-nhanced-t-ransduction-get-peptides-for-sustained-and-highly-efficient-intracellular-delivery

I think Lindy's comments about combinations are just a continuation of her keenness for combinations to attack cancer

a) SCIB1 and Keytruda
b) SCIB2 and a CI (I believe as yet unspecified)
c) Modi1 one of the indications is expected to work better with a specific CI
d) Modi1 and Modi2 together - as highlighted at the 2019 AGM
e) Project Blueprint - although centred on Modi3 combinations were highlighted ("We believe this approach will provide an effective, novel therapy and facilitate
the development of a comprehensive strategy of combinatorial cancer treatment for patients with most types
of cancer.")

So no surprise really.

IMO the rational in the case of Covid19 is that based on having 2 vaccines each with a high success rate using different methodologies. Not every individual will respond well to vaccine A and the same with vaccine B. But the percentage of individuals not responding to both A and B may be very small because A and B use different methods of eliciting an immune response.

It's so clever that Lindy has managed to combine the power of Immunobody with the obvious benefits of Avidimab.
Now we just await confirmation of the delivery method. That in itself could also add to the efficacy of Covidity.

It's a package that could surpass the high bar set by Pfizer and Moderna.
Of course, we have to wait and see just how good Covidity turns out to be but it really could showcase 2 of Lindy's platforms.

Actually, a major factor on the chances of a takeover succeeding is now the attitude of our 3 main IIs (Redmile, Vulpes and Calculus) who between them own just shy of 50% of the shares.

Hi Debs
Where I live the chips would have to be sprayed with seagull repellent but yes I like the idea :-)