Member Info for Prion25

Fruits
I agree that NIH have probably reclassified as a result of Activ 2 better quality data gathered on their viral load investigations , nothing new as we know data exists as far back as Ratko Djukanovic ref virus sputum per gram v beta interferon graph for asthma

I agree I prefer SNG as a dual purpose drug as an immunomodulator and antiviral .It is ironic though, severe disease as result of a cytokine storm requires immunomodulators /anti-inflammatories treatments if direct antivirals are unavailable or failed to work imo

Dame June Raine MHRA unlike Fauci ignored my written plea to consider SNG on ethical grounds Unforgivable

..............we will have a prosperous 2022 !

To everyone on this BB thanks for your research and contributions through the last 18 months ,hopefully we

https://www.theguardian.com/commentisfree/2021/dec/30/the-guardian-view-on-covid-in-2022-new-year-old-pandemic
Sadly,sums up the year .

Thanks matml
https://uk.news.yahoo.com/massive-bird-flu-outbreak-could-153426477.html
There will always be something to worry about and keep Synairgen busy and stockpiling

Thanks again Matterhorn and your thorough attention to detail something sadly I lack

Thanks Matterhorn
Disappointed with the changed in end date change and the publication of results 01/03 /2022 .We will get notice of results before that publication date /end of this current wave? Apologies for my irritability
Results and Publications
Publication and dissemination plan
Planned publication in a high-impact peer-reviewed journal

Intention to publish date
01/03/2022

Individual participant data (IPD) sharing statement
The datasets generated and/or analysed during the current study during this study will be included in the subsequent results publication

I see ORPH has won another contract with a biotech company for a human challenge study of an antiviral for influenza.Appears a lot of interest and money being thrown at respiratory viruses

Eminent scientists have provided empirical key milestone medical evidence for the aetiology/causation of severe Covid disease highlighting serious deficiencies in IFN -beta. Such deficiencies result from Coronavirus spike ACE cell interaction ,impaired genes , autoantibodies ,gender age etc weakening the innate immunity and its ability to reduce the viral load and fight off infection .Synairgen treatment “tops up “ IFN beta to stimulate genes to produce a cascade of immunity against all viruses and variants thus its termed agnostic. Bats have evolved to be rich in interferons never suffer disease but are carriers of hundreds of coronavirus mutations .Unlike vaccines /Mabs Omicron should not be problem to Synairgen’s treatment . imo

Could not access The Times had to settle for The Sun
https://www.thesun.co.uk/news/17083277/uk-covid-cases-to-hit-2m-by-new-year/
"THOUSANDS of Covid patients will be treated in "virtual wards" at home as scientists warn cases could hit a grim 2 million a day by the New Year.
NHS England director Professor Stephen Powis said the health service was on a "war footing" and planned to treat 15 per cent of Covid patients remotely by monitoring their oxygen levels."

This potential troubling news could be more of a potential problem for the Pfizer pill They have only done in vitro experimentation on Omicron. The oral in vivo treatment could be more challenging to eradicate compared to the other variants ?imo

Thanks Matml
Much appreciated the next question would be why the drug does not work in the vaccinated , there is some tenuous evidence of vaccine drug interactions come into play I will research further .ATB

TommyD
Not sure what the meant by" mixed data "in the vaccinated subset

" Pfizer is also studying its pill in lower-risk adults including a subset who are vaccinated but reported mixed data for that group on Tuesday."

From my previous limited knowledge Polyvalent respiratory virus vaccines is that they have been successful in pig and cattle diseases. Whitty says they will be available in 18 months I can see the rationale for such an approach having a polyvalent vaccine for say Beta Delta Omicron, whether they will be mRNA based I am not sure but will the usual caveats still exist with this challenging virus? Waning efficacy, boosters required and rapid emergence of novel variants by passing the vaccines. Sng001 will be a very significant therapeutic in Whitty’s call to arms because it is broad spectrum agnostic, we all know interferon beta has evolved to protect bats against many hundreds of coronavirus mutations. Also inhaled interferon replenishes interferon deficiency of the innate immune as result of the virus infection ,genetics and autoantibodies filling shortfall of the adaptive immune system induced by vaccines

Mr Costs
I am not to concerned about Delta in vitro results .If Sng001 was ineffective against Delta being the dominant strain in the US it would have not been elevated to Active P3.Adagio had astounding in vitro results against Omicron but the in vivo results were disappointing However I would like to see SNG report in vitro results for Omicron or better still proof that it works in vivo / in patients

Thanks Matml
Great to here from a very relaxed smiling Sir Stephen ,yes the knighthood may have had something to do with it , but I am sure his greatest life's ambition to deliver a successful treatment to the world appears to be a smile of an anticipation of considerable fulfillment

https://news.in-24.com/news/361915.html

ND71
I do not think SNG are overly concerned about in vitro experiments , moreover they will hopefully demonstrate potency against all circulating VOC s in VIVO with P3 .I understand your frustration though ,it would be of more expedience to undertake neutralising test on Omicron imo