Member Info for potnak

I am an IT service manager and maintenance is done out of hours. The fact that the internet is a 24 hours service isn't my problem. For my paying customers who have a 24 hours service, we'd spin up a virtual environment for them until OUR maintenance is complete. To get nothing, not even a holding page is poor. I didn't get notifications emails for RNS' logged this morning and there were still DB errors on some pages right into mid-morning. If trading was my main source of income, i'd be looking for a new provider now.

It was broken all night as far as I was concerned. I lost it around 18:00 I think and it was still down when I went to bed. The hilarious thing is I actually pay for this service!!

It's all just part of trading stocks and shares. MM's use the (antiquated) system to make the market. They can place the trades that appear to be the opposite of what they actually are. This can panic traders into think everyone is selling so they should sell or buy because everyone is buying. But without this manipulation, we wouldn't be able to trade. The reality is, at the end of the day, the books need to be balanced and generally, MM's don't like to carry a huge float of shares. So buys and sell are quite evenly matched on a daily basis. MM's are a necessary evil as are incorrectly reported trades.

Not being patronising but why does it matter? You know you bought and that's all that matters. I don't get the fascination with the SP. Other than that's what the last punter paid, it means nothing. You can't work out your profit with the SP because you won't get that when you sell, you're better off using the bid price.

Buy on rumour, sell on news. Planned news updates tend to be just that. It'll be an update. Deals, JV's, T\O etc... all get released via an RNS as and when they happen.

The FDA isn't going to approve this without another PIII study. They (IMM) have to work out why 46% of patients responded when only taking the placebo! Without knowing that, they can't be sure if Lupuzor is working or if that in itself is just a placebo too. The next big news here could be a licence agreement but that all depends on evidence in the data.

It's just someone getting spanked. The MM's are in business too. Whoever sold knew the bid and still accepted it. No conspiracy. they probably need the money for a shorter term investment.

Ha ha MrBrown, that just made me laugh. I'm imagining the IMM board sat around a table right now. "what are we going to do?" they ask. "I know we'll go to the LSE board, they'll know". I'm going back to lurking. If that's where they are. They are in worse trouble than I thought.

It was only 8% better than the placebo? And the no side effects thing probably means it isn't doing anything. I agree there could be a sub set of patients that it might work for but until you know what the plan is, again, why would you buy?

Yes, the dead cat bounce is a real thing but why would anybody buy when the drug failed PIII? This may have legs but buying before you know the plan is like putting your money on the zero on a roulette table.

It feels like Sierra are in a game of poker. They are obviously going all out with chk1 but they will need a backer or backers with deep pockets to get where they (and we) want to be. I will wait until the end of next year if I have to but I think the decision will be taken out of our hands before then. Following the IMM board in the last few weeks has made me think I'd welcome the decision not being mine.

Same here Utar. 48,1 child, work in IT management but feel my soul is slowly dying. Aim is to get my daughter at least to uni with enough to see her through. Then hopefully, I'll have enough to retire. TM and SAR could make that much easier for me.

Sar need to get their TYK2 Lupus train on the tracks! Going to be an interesting day over there.

It was hype though Utar. A 500k contract is never worth the £20 + million that was added to the MC. Im not knocking it. PYC was on my watch list for a couple of years. Another multi bag I missed ha ha.

I started buying back in at 0.185 and sold 1.2 I think. Bought a couple of million back at 0.94 and have been a holder ever since. At the time it was the most money I'd ever made as profit, not the biggest percentage profit though. Had a 6 bagger once.

Its my belief that someone will come along and buy our share of CHK1 and I think we'd get 200 mil for a deal like that. If that happened tomorrow, it would go from 1 to 10p in a straight line. Would I sell, even with TYK2 still in the pot? Yes, I think I would. I'd maybe leave half a million to ride though.

Erm, PYC went from less than 1p to 32p on pure hype. 10 baggers happen all the time. Ive missed at least 2 on stock that I've been watching in the last couple of years. We could get 10p easy, just for our share of CHK1.

10p would be a pot if gold for me! I'm aware of the potential riches we 'could' get but I too would bite their hands of for 10p. You only have look at the IMM board to see the stress of being in PIII. 10p would net me approx £230k.

To be fair. Anything less than �500mil would be cheap IF just one compound made it to market. It's a big if though. If we were asked I'd take anything between �200 and �500 mil. Any less than �200 mil is taking the p***

That the key Aber. Being best in class may not be the best for us PI's.