The latest Investing Matters Podcast episode featuring Jeremy Skillington, CEO of Poolbeg Pharma has just been released. Listen here.
You rewrite history so many times one day you'll get back to the starting universe. You are an evil charlatan anyone with a memory or the ability to read your history can see it for themselves. Nothing more from me here - I was just popping in to exchange pleasantries with Pdub and applaud his 9:00 post summary and as usual you appear - worried I might actually share something useful and the cabal doesn't like it ?
Https://www.lse.co.uk/profiles/cindercone/?page=28
you were banned from May 2020 until Feb 2021 when you cried and crawled and got back in inexplicably. Those of us who were around don't forget your multiple identities all playing off each other and screwing people over. You are a nasty piece of work with your own nefarious agenda and so you try and defame anyone who ever did and shared proper informed research.
"The 18x was based on 6x dose, the increased dosage is overlooked by most people that post 18x. If we get 18x based on escalations to date it would be phenomenal"
PL75 17:16 sat
because i'm pretty sure the 18 refers to dox because 18 times more vitamin C or asprin or water or whatever wouldn't be nearly as interesting
you're all wasting your time. The pit pony simply doesn't understand "a dose"
he thinks if you are drinking Carling and you have a pint and he is drinking lemonade and he has 6 pints then he has had six times your dose .
But dose of what ? water or alcohol or maybe he's just thick
https://avacta.com/wp-content/uploads/2021/11/IWC-2021-Avacta-Presentation.pdf
Slide 11
https://avacta.wistia.com/medias/xzmds8p6fy 7:01 mins
write to them and ask Bell end - every slide set other than this one they give the numbers on this one they didn't but if you speak to them they will tell you it is an error. I know it's hard for you with your years of investment in meaningless rhetoric but you are (as so very often) wrong
except it's not 6 times the dose Twat is it because you have forgotten to convert AVA6000 to doxorubicin - try reading the units clipperty clop. You are very good at rudeness, snide point scoring humour and trying to play the big man but your science is non existent, your maths is poor and your ability to learn negligible.
2mg/kg doxorubicin compared to 12mg/kg AVA6000 is 12*.675 = 8.1mg/kg doxorubicin which is the dose you numpty and 8.1/2 is approx 4 not 6
"The 18x was based on 6x dose, the increased dosage is overlooked by most people that post 18x. If we get 18x based on escalations to date it would be phenomenal"
PL75 17:16 sat
Check your maths, it's 4X not 6X (4.05 actually)
And at 200mg/m2 AVA6000 it is easily putting a minimum of 16 times the standard dose of doxorubicin into the Tumour, probably more.
Ta-Da separated. Well this is exactly what we are doing. The insoluble salts are left behind and our Vanadium containing Sodium Vanadate is dissolved in the water. The water is then evaporated down to form something we call the pregnant solution, this just means a concentrated solution. Unlike my sugar example, we don’t just evaporate off the water, it is a more efficient extraction to now throw in some Ammonia salts to change our soluble Sodium Vanadate into insoluble Ammonium Vanadate which just falls out of the solution as a precipitate. The most common and abundant Ammonium Vanadate salt formed is Ammonia MetaVanadate which you will have read about referred to as AMV.
The AMV is a saleable product and there is a market for it, but we typically go through a couple more basic chemistry steps to create out end products either the V2O5, V2O3 (or at Vametco a mixture of the two we call Modified Vanadium Oxides – MVO).
Ophidian
Right, onto Salt Roasting……. Those rocks containing in part the magnetite matrix are crushed up and then passed over magnets to pull off the magnetite part leaving behind the other rocks. This concentrate is then ground down to a consistent particle size typically somewhere between 30 and 200 microns (um) the actual size is something which is established for each salt roaster independently and is a function (in part) of the relative contents of each element. Most chemistry is surface area related and so the smaller the grind, the bigger the relative surface area, now go too small and the effort you put into making it small also generates energy which in turn causes unwanted oxidation of the surface which impedes the chemistry you want to happen later. Too big and the surface area to volume is too big to get all the chemistry you want going and you get lower yields. Anyway, once ground up, the Magnetite concentrate is mixed with Sodium salts – why Sodium Salts ? Because we are endeavouring to make something that will be soluble in water so we can dissolve it away from all the things we don’t want and separate it away. Now our target is to create SodiumVanadate which is a molecule containing Sodium, Vanadium and Oxygen. Not that it matters but the formula is 2NaVO3 and the reaction we use to create it is shown below: (remember the Vanadium is in the form of V2O5 locked into the Magnetite Matrix)
Na2CO3 + V2O5 - - > 2NaVO3 + CO2
There are other chemical formed along the way of course with the Iron and Titanium in the Magnetite and also with the other impurities we mentioned. Some of these are themselves “Vanadate” salts i.e. Vanadium and Oxygen containing salts of the other elements. These however are insoluble in water but the fact that they are formed at all is a problem because obviously that wastes Vanadium that we can’t get out later. As it happens one such Impurity is Calcium Vanadate which by a happy coincidence undergoes a secondary reaction in the presence of Sodium salts to form yet more Sodium Vanadate (I won’t bore you with the reaction). Importantly now, these other reactions creating other (unwanted) chemicals can to some extent at least be controlled by something as simple as the temperature of the Kiln. All chemical reactions require some sort of energy to kick them off and by holding the temperature of the Kiln in a place that is optimal for our preferred reaction between Vanadium and the Sodium Salts we can optimise the process. I’ll come back to this later.
OK so that is the “Roasting” part of the process, next come the “Leaching”. Basically, the Sodium Vanadate (2NaVO3) is dissolved in water. Think of this like separating sugar from sand. If you had a mix of sand and sugar, you could add water, dissolve the sugar leaving behind the sand. Filter off the Sand and then evaporate the water away to get your sugar out of the sugary water solution. Ta-Da separated.
@Cereal-killer - I wrote this about 5 years ago for this board but I think it might still help:
I’m not sure how familiar everyone is with the Salt Roast Process, why we use it and what it does or indeed how it is affected by different inputs so I’ve put together a brief description for everyone.
Basically, as we get it out of the ground our Vanadium is in the rocks, but not evenly spread through the rocks, it concentrates in a crystalline matrix along with Iron and Titanium in a mineral formation that we call titaniferous-magnetite or just magnetite. When we get reports of the Magnetite content of our assets it is usually quoted as V2O5 in magnetite, so some may be wondering if it is already V2O5 why do we go to all the hassle of the salt roast process to make V2O5, isn’t there an easy way to just separate it out? The answer sadly is no there isn’t. The Vanadium is held in a complex crystalline matrix in which Iron, Titanium, Vanadium and substantially Oxygen atoms are rigidly packed together. Importantly there are a few others in there too notably Aluminium, Chromium, Calcium and Manganese in much lower abundance but the presence of these “impurities” is quite important later. Way back in the stone-age, cavemen probably first encountered “metal” as a strange shiny, malleable “rock” that they found at the bottom of their Fires. They had accidentally “smelted” metal from metal ores by having used the metal ore rocks in and around their fires as containment or for cooking (hot rocks packed with bound food and buried is an ancient cooking method). It was from these observations that the first metal production almost certainly emerged. So why can’t we just “Smelt” out our Vanadium. Well as it happens – we can and this is actually part of the process by which most Vanadium worldwide is produced, as a secondary product in the Iron and Steel Industry.
The typical titanomagnetite smelting operation entails (very simplistically) feeding the titanomagnetite with coal into a pre-reduction kiln. The prereduced material is then conveyed to a furnace where it is smelted to produce a vanadium-bearing pig iron metal and a by-product titania (TiO2)-rich ****. The vanadium-bearing pig iron is tapped into a shaking ladle where it undergoes oxidisation of vanadium into the **** phase. The iron metal from the ladle is tapped off for the production of steel. The remaining vanadium **** is then tipped out, cooled then crushed and the iron entrainment is removed by means of an overhead magnet leaving Vanadium (not very pure) behind. More typically that Vanadium **** (at anywhere between 20%- 33% Vanadium) is put through a salt roast process as we are about to discuss instead. It’s worth pointing out that Vanadium made through this classic “secondary” production process has a recovery of about 55-60%, so very wasteful compared with our Primary production method.
(cont)
grief you poor sad narcissistic nonentities do spout some unbelievable claptrap. Please can we just go back to the Ophidian is never right narrative that one used to make me smile at least - now I just cringe and wince that you make yourselves look so completely barking
In the Q&A he suggested that they would have to pay down the outstanding as far as they could using cash generated in the business. He also hinted at an alternative (undisclosed) approach too but that to be honest is pretty typical Fortune.
They need to do what they should have done 5 years ago - Farm out a chunk of Mokopane, clear all the debt and start leveraging their major resource assets for them.